[1]方识进.中西医结合治疗甲型H1N1流感病毒性小儿呼吸道感染的临床疗效[J].西部中医药,2021,34(12):112-115.[doi:10.12174/j.issn.2096-9600.2021.12.30]
 FANG Shijin.Clinical Effects of Integrative Medicine in Treating Respiratory Tract Infection in Children Caused by Influenza A (H1N1) Virus[J].Western Journal of Traditional Chinese Medicine,2021,34(12):112-115.[doi:10.12174/j.issn.2096-9600.2021.12.30]
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中西医结合治疗甲型H1N1流感病毒性小儿呼吸道感染的临床疗效
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
34
期数:
2021年12期
页码:
112-115
栏目:
衷中参西
出版日期:
2021-12-15

文章信息/Info

Title:
Clinical Effects of Integrative Medicine in Treating Respiratory Tract Infection in Children Caused by Influenza A (H1N1) Virus
作者:
方识进
安徽省儿童医院,安徽 合肥 230001
Author(s):
FANG Shijin
Anhui Provincial Pediatric Hospital, Hefei 230001, China
关键词:
甲型H1N1流感病毒呼吸道感染小儿热速清糖浆奥司他韦临床疗效炎症因子
Keywords:
A H1N1influenza virusrespiratory tract infectioninfantile syruposeltamivirclinical effectsinflammatory factors
分类号:
R373.1+3
DOI:
10.12174/j.issn.2096-9600.2021.12.30
文献标志码:
B
摘要:
目的观察小儿热速清糖浆联合奥司他韦治疗甲型H1N1流感病毒性性小儿呼吸道感染的疗效及其对患儿血清炎症因子的影响。 方法选择甲型H1N1流感病毒性呼吸道感染患儿94例,随机分为观察组和对照组,每组47例。对照组给予口服奥司他韦,观察组在对照组治疗基础上口服小儿热速清糖浆。观察两组患儿临床疗效、症状改善情况,比较两组患儿治疗前后动脉血气指标变化,对比治疗前后血清白细胞介素4(interleukin-4,IL-4)、白细胞介素8(interleukin-8,IL-8)、肿瘤坏死因子α(tumour necrosis factor-α,TNF-α)、C反应蛋白(C-reactive protein,CRP)等炎症因子水平的差异。 结果观察组退热时间、咳喘缓解时间、肺部啰音消失时间、病毒核酸转阴时间均明显短于对照组(P<0.05);总有效率观察组为95.74%(45/47),对照组为82.98%(39/47),差异有统计学意义(P<0.05);两组治疗后动脉血氧分压(partial pressure of oxygen,PaO2),PaO2/吸入气中的氧浓度分数(fraction of inspiration,FiO2)水平均高于治疗前,且观察组改善程度优于对照组(P<0.05),两组治疗后血二氧化碳分压(partial pressure of carbon dioxide,PCO2)低于治疗前,且观察组改善程度优于对照组(P<0.05);两组治疗后血清IL-4、IL-8、TNF-α及CRP水平均低于治疗前(P<0.05),且观察组改善程度优于对照组(P<0.05)。 结论采用小儿热速清糖浆联合奥司他韦治疗甲型H1N1流感病毒性小儿呼吸道感染可显著改善临床症状,缩短病程,降低患儿血清炎症反应,临床疗效确切。
Abstract:
ObjectiveTo observe clinical effects of infantile Resuqing syrup combined with oseltamivir in the treatment of respiratory tract infection (RTI) in children caused by influenza A (H1N1) virus and its influence on serum inflammatory factor in children. MethodsAll 94 children suffering RTI caused by H1N1 virus were chosen, and randomized into the observation group and the control group, 47 cases in each group. The control group took oseltamivir orally, and the observation group was given infantile Resuqing syrup based on oseltamivir. To observe clinical effects and the improvements of the symptoms between both groups, to compare the changes of arterial blood gas indexes before and after treating between both groups, and compare the difference in the levels of inflammatory factors including IL-4, IL-8, TNF-α and CRP before and after treating. ResultsThe observation group was shorter than the control group notably in antipyretic time, cough and asthma relief time, lung rale disappearing time and virus nucleic acid negative time (P<0.05); total effective rate of the observation group was 95.74% (45/47), higher than 82.98% (39/47) of the control group, and the difference had statistical meaning (P<0.05); the levels of PaO2 and FiO2 of both groups were higher than these before treating, and the improvements of the observation group were superior to these of the control group (P<0.05), PCO2 of both groups after treating were lower than these before treating, and the improvements of the observation group were better than these of the control group (P<0.05); the levels of IL-4, IL-8, TNF-α and CRP of both groups after treating were lower than these before treating (P<0.05), and the improvements of the observation group were better than these of the control group (P<0.05). ConclusionInfantile Resuqing syrup and oseltamivir in treating RTI in children caused by influenza A (H1N1) virus could notably improve clinical symptoms of the children, shorten the course of the disease, reduce inflammatory reaction of the children, and it could obtain notable clinical effects spread and application.

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备注/Memo

备注/Memo:
方识进(1977—),男,副主任医师。研究方向:小儿哮喘的诊治。安徽省卫计委儿科医学科研课题(2017ek009)。
更新日期/Last Update: 2021-12-15