[1]林宁,王嘉俊,廖伍萍,等.中西医结合治疗桥本甲状腺炎疗效的Meta分析[J].西部中医药,2022,35(05):62-67.[doi:10.12174/j.issn.2096-9600.2022.05.16]
　LIN Ning,WANG Jiajun,LIAO Wuping,et al.Meta Analysis of Clinical Effects of Integrative Medicine in the Treatment of Hashimoto's Thyroiditis[J].Western Journal of Traditional Chinese Medicine,2022,35(05):62-67.[doi:10.12174/j.issn.2096-9600.2022.05.16]
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中西医结合治疗桥本甲状腺炎疗效的Meta分析
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
35
期数:
2022年05期
页码:
62-67
栏目:
出版日期:
2022-05-15

文章信息/Info

Title:
Meta Analysis of Clinical Effects of Integrative Medicine in the Treatment of Hashimoto's Thyroiditis
作者:
林宁, 王嘉俊, 廖伍萍, 文莹
广东省第二人民医院中医科，广东 广州 510317
Author(s):
LIN Ning, WANG Jiajun, LIAO Wuping, WEN Ying
TCM Department, Guangdong Second Provincial People's Hospital, Guangzhou 510317, China
关键词:
桥本甲状腺炎; 随机对照试验; 中西医结合; Meta分析
Keywords:
Hashimoto's thyroiditis; randomized controlled trial; integrative medicine; Meta analysis
分类号:
R581
DOI:
10.12174/j.issn.2096-9600.2022.05.16
文献标志码:
A
摘要:
目的系统评价中西医结合治疗桥本甲状腺炎（Hashimoto's thyroiditis，HT）的疗效，为临床治疗桥本甲状腺炎提供循证医学证据。 方法搜索2009年1月至2019年12月发表的中西医结合与单纯西药治疗HT的随机对照试验（RCTs）。对这些文献进行筛选，提取符合纳入标准的数据。采用Stata 15.0软件分析数据，并对纳入研究进行发表偏倚分析和敏感性分析。 结果共纳入文献11篇，包括932例患者。观察组临床疗效明显优于单纯西药组（OR=1.24，95%CI［1.02，1.50］，P＜0.005）。观察组在改善甲状腺过氧化酶抗体（thyroid peroxidase antibody，TPOAb）和甲状腺球蛋白抗体（thyroglobulin antibody，TGAb）方面明显优于单纯西药组（SMD=-2.70，95%CI［-3.56，-1.83］，P＜0.01；SMD=-2.08，95%CI［-3.03，-1.34］，P＜0.05）。 结论中西医联合治疗桥本甲状腺炎临床疗效优于单纯西药组，可明显降低TGAb、TpoAb浓度。
Abstract:
ObjectiveTo provide evidence-based medicine evidence for clinical therapy of Hashimoto's thyroiditis (HT) by systematically assessing clinical effects of integrative medicine in the treatment of HT. MethodsAfter searching RCTs on integrative medicine and single Western medicine in treating HT between January, 2009 and December, 2019, the data were screened to extract the data met the inclusion criteria. Stata 15.0 software was adopted to analyze the data, publication bias analysis and sensitivity analysis were performed for the included studies. ResultsAll 11 articles were included, involving 932 patients. Clinical effects of the observation group were notably better than these of single Western medicine group (OR=1.24, 95%CI[1.02, 1.50], P＜0.005). The observation group was better than single Western medicine group in improving TPOAb and TGAb notably (SMD=-2.70,95%CI[-3.56,-1.83], P＜0.01; SMD=-2.08, 95%CI[-3.03,-1.34],P＜0.05). ConclusionIntegrative medicine is superior to single Western medicine group in the treatment of HT, it could notably decrease the concentrations of TGAb and TpoAb.

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备注/Memo

备注/Memo:
林宁（1975—），女，博士学位，副主任医师。研究方向：代谢及自身免疫疾病的中西医结合治疗。2016年广东省中医药局常规科研项目（20162005）。
更新日期/Last Update: 2022-06-24