[1]李时雨,莫蕙,许家莹,等.基于卵巢颗粒细胞功能探讨调周法治疗卵巢储备功能减退的临床研究[J].西部中医药,2024,37(01):150-153.[doi:10.12174/j.issn.2096-9600.2024.01.30]
　LI Shiyu,MO Hui,XU Jiaying,et al.Clinical Study on the Treatment of Diminished Ovarian Reserve by Regulating Cycle Based on the Function of Ovarian Granulosa Cells[J].Western Journal of Traditional Chinese Medicine,2024,37(01):150-153.[doi:10.12174/j.issn.2096-9600.2024.01.30]
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基于卵巢颗粒细胞功能探讨调周法治疗卵巢储备功能减退的临床研究
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
37
期数:
2024年01期
页码:
150-153
栏目:
出版日期:
2024-01-15

文章信息/Info

Title:
Clinical Study on the Treatment of Diminished Ovarian Reserve by Regulating Cycle Based on the Function of Ovarian Granulosa Cells
作者:
李时雨1, 莫蕙1, 许家莹2, 陈赟2
1.澳门科技大学，澳门特别行政区 999078
2.南京中医药大学附属医院，江苏 南京 210000
Author(s):
LI Shiyu1, MO Hui1, XU Jiaying2, CHEN Yun2
1.Macau University of Science and Technology, Macau 999078, China
2.Affiliated Hospital of Nanjing University of TCM, Nanjing 210000, China
关键词:
肾虚证; 卵巢储备功能; 卵巢颗粒细胞; 调周法; 抗缪勒氏管激素
Keywords:
renal deficiency pattern; diminished ovarian reserve; ovarian granulosa cells; cycle-regulating method; anti-mullerian hormone
分类号:
R271.14
DOI:
10.12174/j.issn.2096-9600.2024.01.30
文献标志码:
B
摘要:
目的基于卵巢颗粒细胞功能探讨中医药调周法对卵巢储备功能减退（diminished ovarian reserve，DOR）患者体内抗穆勒氏管激素（anti-mullerian hormone，AMH）水平的影响及临床疗效。 方法对60例DOR肾虚证患者给予中医药调周法治疗，观察治疗前后患者血清性激素各项水平［AMH、雌二醇（estradiol，E2）、黄体生成素（luteinizing hormone，LH）、卵泡刺激素（follicle stimulating hormone，FSH）］和临床疗效。 结果治疗前后E2、LH、FSH水平比较差异无统计学意义（P＞0.05）；治疗后AMH水平较治疗前升高（P＜0.05），中医证候积分较治疗前减少（P＜0.05），总有效率为86.7%（52/60）；治疗期间均无明显不良反应。 结论中药调周法通过提高AMH、FSH水平来提升DOR肾虚证患者卵巢储备功能，调整月经周期，增加月经量，改善临床症状。
Abstract:
ObjectiveTo discuss the influence and clinical effects of TCM cycle-regulating method on the levels of anti-mullerian hormone (AMH) in patients with diminished ovarian reserve (DOR) on the foundation of the function of ovarian granulosa cells. MethodsSixty DOR patients of renal deficiency pattern were treated by TCM cycle-regulating method，To observe the levels of serum sex hormones (E2, LH and FSH), clinical effects before and after the treatment. ResultsThe difference had no statistical meaning in the levels of E2, LH and FSH before and after the treatment (P>0.05); after the treatment，the levels of AMH were elevated compared with before the treatment (P<0.05), TCM syndrome integrals were reduced than before the treatment (P<0.05), total effective rate was 86.7%（52/60）, no obvious adverse reaction occurred during therapeutic period. ConclusionConclusionTCM cycle-regulating method could improve renal deficiency pattern DOR patients' ovarian reserve, regulate the menstrual cycle，increase menstrual flow and improve the patients' clinical symptoms possibly through increasing the levels of AMH and FSH.

相似文献/References:

[1]陈玉庆,潘文,刘迎萍,等.安坤种子丸对卵巢储备功能下降(肾虚证)患者AMH及INHB的影响[J].西部中医药,2018,31(02):90.
　CHEN Yuqing,PAN Wen,LIU Yingping,et al.Influence of AnKun ZhongZi Pills on AMH and INHB of the Patients Suffering from Decreased Ovarian Reserve of Renal Deficiency Pattern[J].Western Journal of Traditional Chinese Medicine,2018,31(01):90.
[2]杨碧蓉,周华.补肾活血法对子宫内膜异位症患者卵巢储备功能的影响[J].西部中医药,2019,32(03):138.
　YANG Birong,ZHOU Hua.Influence of Kidney-tonifying Blood-activating Method on Ovarian Reserve Function of the Patients with Endometriosis[J].Western Journal of Traditional Chinese Medicine,2019,32(01):138.

备注/Memo

备注/Memo:
李时雨（1993—），女，硕士学位，医师。研究方向：妇科疾病的中医药防治。国家自然科学基金（81574009）；江苏省卫生计生委科研课题（Q201602）；第三批江苏省名老中医傅友丰工作室项目；南京中医药大学中医学优势学科教育教改研究课题（Q201602）。
更新日期/Last Update: 2024-01-15