[1]刘猛,高家荣,魏良兵.多指标综合评分法优选参术调脾颗粒方中白术和陈皮的醇提取工艺[J].西部中医药,2024,37(07):5-9.[doi:10.12174/j.issn.2096-9600.2024.07.02]
 LIU Meng,GAO Jiarong,WEI Liangbing.Optimization of Alcohol Extraction Process of Baizhu and Chenpi in Shenzhu Spleen-adjusting Granules by Multi-index Comprehensive Scoring Method[J].Western Journal of Traditional Chinese Medicine,2024,37(07):5-9.[doi:10.12174/j.issn.2096-9600.2024.07.02]
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多指标综合评分法优选参术调脾颗粒方中白术和陈皮的醇提取工艺
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
37
期数:
2024年07期
页码:
5-9
栏目:
质量分析
出版日期:
2024-07-15

文章信息/Info

Title:
Optimization of Alcohol Extraction Process of Baizhu and Chenpi in Shenzhu Spleen-adjusting Granules by Multi-index Comprehensive Scoring Method
作者:
刘猛1, 高家荣2, 魏良兵2
1.皖西卫生职业学院附属医院,安徽 六安 237008
2.安徽中医药大学第一附属医院,安徽 合肥 230031
Author(s):
LIU Meng1, GAO Jiarong2, WEI Liangbing2
1.Affiliated Hospital of West Anhui Health Vocational College, Lu'an 237008, China
2.The First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei 230031, China
关键词:
参术调脾颗粒提取工艺白术内酯Ⅰ白术内酯Ⅲ多指标综合评分法
Keywords:
spleen-adjusting granulesextraction processatractylenolide Ⅰatractylenolide Ⅲmulti-index comprehensive scoring method
分类号:
R283
DOI:
10.12174/j.issn.2096-9600.2024.07.02
文献标志码:
A
摘要:
目的优选参术调脾颗粒方中白术和陈皮的最佳醇提取工艺。 方法以参术调脾颗粒中醇溶性浸出物、白术内酯Ⅰ和白术内酯Ⅲ的含量为醇提取工艺的考察指标,通过多指标综合评分法考察不同因素和水平对提取工艺的影响。 结果参术调脾颗粒方中白术和陈皮最佳醇提取工艺为A1B3C2D3,即乙醇浓度65%,加10倍量乙醇,每次提取1.5 h,提取3次。 结论优选的参术调脾颗粒方中白术和陈皮醇提取工艺合理可行,有效成分提取效率高。
Abstract:
ObjectiveTo optimize the best alcohol extraction process of Baizhu (Atractylodis macroce-phalae rhizoma) and Chenpi (Citri reticulatae pericarpium) in Shenzhu spleen-adjusting granules. MethodsThe contents of alcohol soluble extract, atractylolideⅠand atractylolide Ⅲ in Shenzhu spleen-adjusting granules were used as the indexes of alcohol extraction process, and the influences of different factors and their levels on extraction process were investigated using multi-index comprehensive scoring method. ResultsThe best alcohol extraction process of Baizhu and Chenpi from the granules was A1B3C2D3, that is, ethanol concentrations 65%, adding ten times amount of ethanol, extracting for 1.5 h each time, three times. ConclusionThe optimized alcohol extraction process of Baizhu and Chenpi from Shenzhu spleen-adjusting granules is rational and feasible with high extraction efficiency of active ingredients.

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备注/Memo

备注/Memo:
刘猛(1986—),男,硕士学位,副主任药师。研究方向:中药制剂研究与开发、临床药学。国家自然科学基金(81603574)。
更新日期/Last Update: 2024-07-15