[1]刘应东,王翼洲.健脾益气消导方治疗糖尿病胃轻瘫的临床研究[J].西部中医药,2012,25(10):5-8.
　LIU Ying-dong,WANG Yi-zhou.Clinical Study on JianPi YiQi XiaoDaoFang in Treating Diabetic Gastroparesis[J].Western Journal of Traditional Chinese Medicine,2012,25(10):5-8.
点击复制

健脾益气消导方治疗糖尿病胃轻瘫的临床研究()
分享到：

《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
25
期数:
2012年10期
页码:
5-8
栏目:
出版日期:
2012-10-15

文章信息/Info

Title:
Clinical Study on JianPi YiQi XiaoDaoFang in Treating Diabetic Gastroparesis
文章编号:
1004-6852(2012)10-0005-04
作者:
刘应东1，王翼洲2
1 安徽中医学院，安徽 合肥 230038； 2 安徽中医学院第一附属医院干部消化内科
Author(s):
LIU Ying-dong1, WANG Yi-zhou2
1  Anhui University of Traditional Chinese Medicine, Hefei 230038, China;
2  Cadre Department of Gastroenterology in the First Affiliated Hospital to Anhui University  of Traditional Chinese Medicine
关键词:
胃轻瘫; 糖尿病性; 健脾益气消导方; 临床研究
Keywords:
gastroparesis;  diabetic;  JianPi YiQi XiaoDaoFang;  clinical study
分类号:
R587.29
文献标志码:
A
摘要:
目的：观察健脾益气消导方治疗糖尿病胃轻瘫（DGP)的临床疗效。方法：将60例脾虚型DGP患者随机分为治疗组和对照组各30例，2组均给予常规西药降血糖治疗，此外，治疗组给予健脾益气消导方治疗；对照组给予枸橼酸莫沙比利治疗；2组均以4周为1个疗程。观察患者治疗前后临床症状积分、胃排空率、胃动素、空腹血糖(FPG)及早餐后2小时血糖(2 h PG)等指标的改变及不良反应发生情况。结果：治疗组和对照组总有效率分别为86.67%和70.00%，2组疗效比较有显著性差异（P＜0.05)，2组治疗后总症状积分、胃动素、胃排空率、FPG及2 h PG较治疗前显著改善（P＜0.01)，组间比较有显著性差异（P＜0.01)。结论：健脾益气消导方可显著改善脾虚型DGP患者的临床症状，促进胃排空，降低血浆胃动素水平；在西药降血糖、调整饮食的基础上，能显著改善DGP患者的糖代谢紊乱状况。
Abstract:
Abstract  Objective: To investigate clinical efficacy of JianPi YiQi XiaoDaoFang in treating diabetic gastroparesis(DGP). Method: Sixty patients with DGP of spleen deficiency pattern were randomly allocated into therapy group and control group, 30 cases each group. Both groups received conventional western medicine lowering blood glucose, therapy group were treated with JianPi YiQi XiaoDaoFang; control group took mosapride citrate. One session was four weeks. Side effects and changes of clinical symptom, gastric emptying rate, motilin, fasting blood-glucose and 2hours postprandial blood-glucose were observed. Result: Total effective rates of therapy group and control group were respectively 86.67% and 70.00%, comparisons between both groups suggested remarkable difference in curative effects(P＜0.05), total score of symptom, motilin, gastric emptying rate, fasting blood-glucose and 2hours postprandial blood-glucose improved more significant after treating than before(P＜0.01), comparisons between both groups indicated remarkable difference (P＜0.01). Conclusion: JianPi YiQi XiaoDaoFang could improve symptoms of patients with DGP of spleen deficiency pattern notably, promote gastric emptying and lower level of motilin in plasma; it also can improve remarkably disorders of glucose metabolism on the basis of western medicine lowering blood-glucose and regulating diet.

参考文献/References:

［1］  杨怀新.补脾益胃理气法治疗糖尿病胃轻瘫99例临床观察［J］.甘肃中医,2008,21(7):15-16.
［2］  李春桂,苗桂珍,王立强.甘草泻心汤联合枸橼酸莫沙必利 治疗糖尿病胃轻瘫的临床观察［J］.河北中医,2009,31（12）：1816-1818.
［3］  吴湘萍,侯广旺,陈立新,等.健脾化浊降逆方治疗脾胃虚弱 型糖尿病胃轻瘫 129例临床观察［J］.河北中医,2012,34(3): 353-354.
［4］  高云峰.半夏泻心汤合四逆散加味治疗糖尿病胃轻瘫35例［J］.甘肃中医，2011，24(2)：46-47.
［5］  周吕，柯美云.神经胃肠病学与动力:基础与临床［M］.北京: 科学出版社，2005：729-742.
［6］  叶盛开，安伶，高艳丽，等.糖尿病胃轻瘫致餐后低血糖反应9例分析［J］.临床军医杂志，2010，38(5)：801-803.
［7］  叶盛开，安伶，王雁，等.糖尿病胃轻瘫致空腹血糖明显升高34例分析［J］.临床军医杂志，2011，39(6)：1155.
［8］  叶任高，陆再英.内科学［M］.6版.北京：人民卫生出版社，2006：797.
［9］  贝政平.内科疾病诊断标准［M］.北京：科学出版社出版，2001：1267.
［10］ 朱文峰.中医诊断学［M］.2版.北京：中国中医药出版社，2007：186.
［11］ 王振华，达四平，龚能平，等.莫沙必利治疗功能性消化不良 多中心双盲对照研究［J］.中国新药与临床杂志，2000，19(5)：363-366.
［12］ 高连战,张宏文,何海波.和胃祛瘀汤治疗糖尿病胃轻瘫46例临床观察［J］.甘肃中医，2008,21(11):44-45.
［13］ Imura H，Seino Y，Mori K，et al.Plasma motilin levels  in normal subjects and patients with diabetes mellitus and certain other diseases.Fasting levels and  responses to food and glucose［J］.Endocrinol Jpn， 1980，27(Supp 1)：151-155.

相似文献/References:

[1]王开放,张建中△.古代治疗糖尿病胃轻瘫组方的用药规律分析[J].西部中医药,2018,31(12):35.
　WANG Kaifang,ZHANG Jianzhong.Analysis of the Medication Rules of Ancient Prescriptions in Treating Diabetic Gastroparesis[J].Western Journal of Traditional Chinese Medicine,2018,31(10):35.
[2]陈远方,张智,余卫锋,等.电针治疗糖尿病胃轻瘫的Meta分析[J].西部中医药,2021,34(03):77.[doi:10.12174/j.issn.2096-9600.2021.03.20]
　CHEN Yuanfang,ZHANG Zhi,YU Weifeng,et al.Meta Analysis of Acusector in the Treatment for Diabetic Gastroparesis[J].Western Journal of Traditional Chinese Medicine,2021,34(10):77.[doi:10.12174/j.issn.2096-9600.2021.03.20]
[3]陈伦,祁佳,张宇锋,等.香砂六君子汤治疗糖尿病性胃轻瘫临床疗效对比研究[J].西部中医药,2016,29(07):90.
　CHEN Lun,QI Jia,ZHANG Yufeng,et al.Curative Effects of XiangSha LiuJunZi Tang in Treating Diabetic Gastroparesis[J].Western Journal of Traditional Chinese Medicine,2016,29(10):90.

备注/Memo

备注/Memo:
收稿日期：2012-04-16  
    *基金项目：2009年度安徽中医学院临床科学研究基金项目(编号2009LC1-008ZX)
    作者简介：刘应东(1986—)，男，硕士学位。研究方向：胃肠动力学。
    △通讯作者：王翼洲(1956—)，男，硕士研究生导师，硕士学位，主任医师。研究方向：胃肠动力学。
更新日期/Last Update: 2012-10-29