[1]梁勤,乔登嫣△,马小明,等.甘肃道地中药大黄、黄芩对多重耐药菌的抑菌活性[J].西部中医药,2014,27(05):5-7.
　LIANG Qin,QIAO Dengyan,MA Xiaoming,et al.Antibacterial Activity of Gansu Genuine Herbs DaHuang and HuangQin on Multiple Resistant Bacteria[J].Western Journal of Traditional Chinese Medicine,2014,27(05):5-7.
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甘肃道地中药大黄、黄芩对多重耐药菌的抑菌活性
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
27
期数:
2014年05期
页码:
5-7
栏目:
出版日期:
2014-05-15

文章信息/Info

Title:
Antibacterial Activity of Gansu Genuine Herbs DaHuang and HuangQin on Multiple Resistant Bacteria
文章编号:
1004-6852(2014)05-0005-03
作者:
梁勤，乔登嫣△，马小明，罗向霞，李喜香，周思彤，窦娇莹
甘肃省中医院，甘肃 兰州 730050
Author(s):
LIANG Qin, QIAO Dengyan△, MA Xiaoming, LUO Xiangxia, LI Xixiang, ZHOU Sitong, DOU Jiaoying
Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730050, China
关键词:
大黄; 黄芩; 多重耐药菌; 抑菌
Keywords:
DaHuang;  HuangQin;  multiple resistant bacteria;  antibacterial Activity
分类号:
R284
文献标志码:
A
摘要:
目的：观察甘肃道地中药材大黄、黄芩的体外抑菌活性，为临床中药治疗耐药菌感染提供参考。方法：采用煎煮法制备大黄、黄芩中药原液,用肉汤稀释法测定两种药液对产超广谱β-内酰胺酶(ESBLs)大肠埃希菌和耐甲氧西林金黄色葡萄球菌（MRSA)的最小抑菌浓度。结果：大黄对产超广谱β-内酰胺酶(ESBLs)大肠杆菌和耐甲氧西林金黄色葡萄球菌(MRSA)的最小抑菌浓度分别为250 mg/mL和125 mg/mL。黄芩对耐甲氧西林金黄色葡萄球菌(MRSA)的最小抑菌浓度为250 mg/mL；对产超广谱β-内酰胺酶(ESBLs)大肠杆菌未见明显抑菌作用。结论：大黄、黄芩对临床常见的多重耐药菌有不同程度的抑菌活性，且大黄的抑菌活性优于黄芩；大黄对金黄色葡萄球菌抑菌活性优于大肠埃希菌。
Abstract:
Objective: To provide reference for herbs in treating drug resistant bacteria infection by observing antibacterial activity of Gansu genuine herbs DaHuang (Rheum palmatum L.) and HuangQin (Scutellaria Baicalensis) in vitro. Methods: The decoctions of DaHuang and HuangQin were prepared, the minimum antibacterial concentrations of two kinds of decoctions for extended spectrum β lactamases(ESBLs) E.coli and methicillin-resistant staphylococcus aureus(MRSA) were detected with broth dilution method. Results: The minimum antibacterial concentrations of DaHuang for producting ESBLs E.coli and MRSA were 250mg/mL and 125 mg/mL. The minimum antibacterial concentrations of HuangQin for producting MRSA were 250mg/mL, and it didn′t show notable antibacterial function to ESBLs E.coli. Conclusion: DaHuang and HuangQin show different degrees of antibacterial activity to common multiple resistant bacteria, and antibacterial activity of DaHuang is superior to that of HuangQin; antibacterial activity of DaHuang to MRSA is superior to that of ESBLs E.coli.

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备注/Memo

备注/Memo:
收稿日期：2014-01-10作者简介：梁勤(1972—)，女，副主任检验师。研究方向：临床检验及微生物学检验。△通讯作者：乔登嫣（1973—），女，副主任检验师。研究方向：临床微生物学检验。
更新日期/Last Update: 2014-05-15