[1]徐倩,李盈,高珊,等.虎藤组方对无症状高尿酸血症患者胰岛素抵抗的影响机制研究[J].西部中医药,2018,31(10):63-65.
　XU Qian,LI Ying,GAO Shan,et al.Effects of HuTeng Medicinal Formula on Insulin Resistance of the Patients with Asymptomatic Hyperuricemia and the Mechanism[J].Western Journal of Traditional Chinese Medicine,2018,31(10):63-65.
点击复制

虎藤组方对无症状高尿酸血症患者胰岛素抵抗的影响机制研究()
分享到：

《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
31
期数:
2018年10期
页码:
63-65
栏目:
出版日期:
2018-10-15

文章信息/Info

Title:
Effects of HuTeng Medicinal Formula on Insulin Resistance of the Patients with Asymptomatic Hyperuricemia and the Mechanism
文章编号:
1004-6852(2018)10-0063-03
作者:
徐倩，李盈，高珊，姚民秀△
青岛市中心医院，青岛 266042
Author(s):
XU Qian, LI Ying, GAO Shan, YAO Minxiu
Qingdao Center Hospital, Qingdao 266042, China
关键词:
高尿酸血症; 无症状; 胰岛素抵抗; 虎藤组方; 作用机制
Keywords:
hyperuricemia;  asymptomatic;  insulin resistance;  HuTeng medicinal formula;  mechanism
分类号:
R977.1+5
文献标志码:
B
摘要:
目的：观察虎藤组方对无症状高尿酸血症患者胰岛素抵抗的影响及机制。方法：将124例患者随机分为观察组、对照组各62例。对照组仅采用低嘌呤饮食干预，观察组同时口服虎藤组方煎剂，1剂/d，水煎分服，干预14天。观察治疗前后2组空腹血糖(FPG)、空腹胰岛素(FINS)、血尿酸(UA)、甘油三酯(TG)、胆固醇(TC)及血清白细胞介素1β(IL-1β)等指标。结果：治疗后与治疗前比较，观察组FPG、IL-1β、UA、TG、FINS及胰岛素抵抗指数(HOMA-IR)降低，差异有统计学意义(P＜0.05)；TC及LDL降低，HDL升高，但差异无统计学意义(P＞0.05)；对照组FPG、FINS、HOMA-IR、IL-1β、UA、LDL、TG、TC等指标均下降，HDL升高，但差异无统计学意义(P＞0.05)。治疗后与对照组比较，观察组FPG、IL-1β、UA、TG、FINS及HOMA-IR降低明显，差异有统计学意义(P＜0.05)；TC及LDL降低，HDL升高，但差异无统计学意义(P＞0.05)。结论：虎藤组方可能通过降低血尿酸及白细胞介素1β，改善胰岛素抵抗，从而降低空腹血糖及胰岛素。
Abstract:
Objective: To observe the effects of HuTeng medicinal formula on insulin resistance of the patients with asymptomatic hyperuricemia and its mechanism. Methods: All 124 patients were randomized into the observation group and the control group, 62 cases each group. The control group were intervened by low purine diet only, and the observation group took the decoction of HuTeng medicinal formula, one dose each day, water decocted, for 14 days consecutively. To observe the indexes including interleukin-1β(IL-1β), total cholesterol (TC), triglyceride (TG), uric acid (UA), fasting insulin (FINS) and fasting plasma glucose (FPG) before and after treating. Results: FPG, IL-1β, UA, TG, FINS and HOMA-IR of the observation group decreased after treating compared with before treating, and the difference showed statistical meaning (P＜0.05); TC and LDL decreased, while HDL rose, and the difference had no statistical meaning (P＞0.05); the indexes of FPG, FINS, HOMA-IR, IL-1β, UA, LDL, TG, TC and others lowered in the control group, while HDL rose, and the difference showed no statistical meaning(P＞0.05). The indexes of FPG, IL-1β, UA, TG, FINS and HOMA-IR of the observation group reduced obviously after treating when compared with the control group, and the difference showed statistical meaning (P＜0.05); TC and LDL decreased, while HDL rose, the difference had no statistical meaning(P＞0.05). Conclusion: HuTeng medicinal formula could decrease FPG and FINS by lowering UA, IL-1β and improving IR.

相似文献/References:

[1]刘圳奋,马红霞,李秀宁,等.痛风性关节炎与高尿酸血症炎性细胞因子水平比较[J].西部中医药,2014,27(08):157.
[2]高万飞,徐厚谦,金华.中医治法对高尿酸血症大鼠模型AngⅠ，AngⅡ水平的影响[J].西部中医药,2015,28(05):22.
[3]侯建平,王亚军,严亚峰,等.虎杖提取物抗动物高尿酸血症的实验研究[J].西部中医药,2012,25(05):21.
　HOU Jian-ping,WANG Ya-jun,YAN Ya-feng,et al.Study of Polygonum Cuspidatum Extract on Anti-Hyperuricemia in Rats and Mice[J].Western Journal of Traditional Chinese Medicine,2012,25(10):21.
[4]张家林,裴瑞霞.银花痛风颗粒治疗2型糖尿病合并高尿酸血症疗效观察[J].西部中医药,2014,27(01):106.
　ZHANG Jialin,PEI Ruixia.Clinical Observation on YinHua TongFeng Granules in Treating Type 2 Diabetes Mellitus Complicated with Hyperuricemia[J].Western Journal of Traditional Chinese Medicine,2014,27(10):106.
[5]邓耒娇,闫洁熙,王沛,等.茯苓多糖对高尿酸血症大鼠肾小管转运体rURAT1、rOAT1和rOCT2表达的影响[J].西部中医药,2019,32(06):10.
　DENG Leijiao,YAN Jiexi,WANG Pei,et al.Effects of Pachman on the Expression of Renal Tubular Transporters rURAT1,rOAT1 and rOCT2 of the Rats with Hyperuricemia[J].Western Journal of Traditional Chinese Medicine,2019,32(10):10.
[6]陈宇阳,黄静瑶,赵恒侠,等.王孟庸从风论治高尿酸血症临证经验[J].西部中医药,2021,34(03):50.[doi:10.12174/j.issn.2096-9600.2021.03.12]
　CHEN Yuyang,HUANG Jingyao,ZHAO Hengxia,et al.Wang Mengyong’s Clinical Experience in Treating Hyperuricemia from Wind[J].Western Journal of Traditional Chinese Medicine,2021,34(10):50.[doi:10.12174/j.issn.2096-9600.2021.03.12]
[7]冯博,王昕冉,齐庆,等.基于中医“治未病”思想探讨高尿酸血症的防治[J].西部中医药,2022,35(12):96.[doi:10.12174/j.issn.2096-9600.2022.12.21]
　FENG Bo,WANG Xinran,QI Qing,et al.The Prevention and Treatment of Hyperuricemia Based on TCM Thought of “Preventive Treatment of Disease”[J].Western Journal of Traditional Chinese Medicine,2022,35(10):96.[doi:10.12174/j.issn.2096-9600.2022.12.21]
[8]杜少鹏,刘维.中药防治痛风和高尿酸血症的研究进展[J].西部中医药,2024,37(07):87.[doi:10.12174/j.issn.2096-9600.2024.07.21]
　DU Shaopeng,LIU Wei.Progress of Research on the Prevention and Treatment of Gout and Hyperuricemia with Traditional Chinese Medicine[J].Western Journal of Traditional Chinese Medicine,2024,37(10):87.[doi:10.12174/j.issn.2096-9600.2024.07.21]

备注/Memo

备注/Memo:
收稿日期：2018-01-23 *基金项目：青岛市卫纪委中医药管理局项目(编号2014-zyy023 )。 作者简介：徐倩(1969—)，女，博士学位，副主任医师。研究方向：中西医治疗高尿酸血证及痛风。 △通讯作者：姚民秀(1963—)，男，主任医师，硕士研究生导师。研究方向：中西医治疗高尿酸血证及痛风。
更新日期/Last Update: 2018-08-15