[1]王艳,张伟,孙静,等.基于量效关系探讨《伤寒杂病论》中当归的用药规律[J].西部中医药,2022,35(04):80-83.[doi:10.12174/j.issn.2096-9600.2022.04.18]
　WANG Yan,ZHANG Wei,SUN Jing,et al.Medication Laws of Danggui in Shanghan Zabinglun Based on Dose-effects Relationship[J].Western Journal of Traditional Chinese Medicine,2022,35(04):80-83.[doi:10.12174/j.issn.2096-9600.2022.04.18]
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基于量效关系探讨《伤寒杂病论》中当归的用药规律
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
35
期数:
2022年04期
页码:
80-83
栏目:
出版日期:
2022-04-15

文章信息/Info

Title:
Medication Laws of Danggui in Shanghan Zabinglun Based on Dose-effects Relationship
作者:
王艳1, 张伟2, 孙静3, 朱向东1
1.甘肃中医药大学基础医学院，甘肃 兰州 730000
2.西安市中医医院脑病科
3.陕西中医药大学第一临床医学院
Author(s):
WANG Yan1, ZHANG Wei2, SUN Jing3, ZHU Xiangdong1
1.Basic Medical College, Gansu University of Chinese Medicine, Lanzhou 730000, China
2.Encephalopathy Department, Xi′an Hospital of Traditional Chinese Medicine
3.The First Clinical Medical College, Shaanxi University of Chinese Medicine
关键词:
当归; 《伤寒杂病论》; 量效关系; 二元相关性分析; 单因素逻辑回归分析
Keywords:
Yaolue; dose-effect relationship; binary correlation analysis; single factor Logistic regression analysis
分类号:
R2-5
DOI:
10.12174/j.issn.2096-9600.2022.04.18
文献标志码:
A
摘要:
目的探究《伤寒杂病论》中当归的量效关系及用药规律，为临床实践提供一定借鉴。 方法系统整理《伤寒杂病论》中含有当归的方剂，采用SPSS 20.0统计软件进行二元相关性分析及单因素逻辑回归分析，探究当归剂量与相关因素之间的关系。 结果《伤寒杂病论》含当归方剂17首，其中10首可进行剂量换算。六经分布显示，其中阳经方为2首（20%），阴经方为3首（30%），阴阳合经方为5首（50%）。二元相关性分析显示，当归单次用量仅与当归剂量有统计学相关性（P=0.045）。单因素逻辑回归分析显示，当归是否为主药与其他因素均无统计学相关性（P＞0.05）。 结论《伤寒杂病论》中当归广泛应用于六经方证中，而其量效关系不明显，临床中应灵活配伍芍药、川芎等，以更好地发挥其疗效。
Abstract:
ObjectiveTo provide a certain reference for clinical practice by exploring the dose-effect relationship and medication laws of Danggui (Angelica sinensis) in Shanghan Zabinglun. MethodsThe prescrip-tions containing Danggui were systematically arranged in Shanghan Zabinglun, SPSS20.0 statistical software was used to perform binary correlation analysis and single factor Logistic regression analysis, and explore the correlation between the dose of Danggui and the related factors. ResultsThere were 17 prescriptions containing Danggui in Shanghan Zabinglun, among them, ten prescriptions could perform dose conversion. The distribution of six meridians displayed that there were two prescriptions of Yang meridians (20%), three prescriptions of Yin meridians (30%) and five prescriptions of Yin and Yang meridians (50%). Binary correlation analysis showed that single dose of Danggui has the statistical relevance to the dose of Danggui (P=0.045). Single factor Logistic regression analysis presented that whether Danggui is the main drug and other factors had no statistical relevance (P>0.05). ConclusionIn Shanghan, Danggui could be widely used in the prescriptions and syndromes of six meridians according to the compatibility, while its dose-effect relationship is insignificant, it should be used in combination with Shaoyao (Paeonia lactiflora), Chuanxiong (Rhizoma Chuangxiong) and others flexibly in clinic, in order to better develop its clinical effects.

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备注/Memo

备注/Memo:
王艳（1995—），女，在读硕士研究生。研究方向：老年病、糖尿病的中医诊治。甘肃省中医药管理局中医药防治重大疾病科研课题（2018ZD04）。
更新日期/Last Update: 2022-06-24