[1]罗乐,孙书臣,谢瑛.基于古籍的多寐发病机制及用药规律探析[J].西部中医药,2023,36(05):68-71.[doi:10.12174/j.issn.2096-9600.2023.05.15]
　LUO Le,SUN Shuchen,XIE Ying.Exploration into the Mechanism and Medication Rules of Somnolence on the Foundation of Ancient Books[J].Western Journal of Traditional Chinese Medicine,2023,36(05):68-71.[doi:10.12174/j.issn.2096-9600.2023.05.15]
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基于古籍的多寐发病机制及用药规律探析
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
36
期数:
2023年05期
页码:
68-71
栏目:
出版日期:
2023-05-15

文章信息/Info

Title:
Exploration into the Mechanism and Medication Rules of Somnolence on the Foundation of Ancient Books
作者:
罗乐1, 孙书臣1, 谢瑛2
1.中国中医科学院广安门医院，北京 100029
2.首都医科大学附属北京友谊医院，北京 100050
Author(s):
LUO Le1, SUN Shuchen1, XIE Ying2
1.Guang'anmen Hospital, China Academy of Chinese Medical Sciences, Beijing 100029, China
2.Beijing Friendship Hospital Affiliated to Capital Medical University, Beijing 100050, China
关键词:
多寐; 病因病机; 用药规律; 聚类分析; 古籍
Keywords:
somnolence; the cause and pathogenesis; medication laws; cluster analysis; ancient books
分类号:
R25
DOI:
10.12174/j.issn.2096-9600.2023.05.15
文献标志码:
A
摘要:
目的探索古籍中多寐的病因病机特点及用药规律。 方法搜索历代古籍中对多寐的相关论述及治疗方剂，采用Excel及SPSS 21.0统计软件对多寐的病因病机及中药性、味、归经等进行频数和聚类分析。 结果1）古籍条文中多寐的病因病机主要有热邪伤阴、卫气滞阴、脾病湿困、胆热肝实、心虚神乱、阴病阳虚等；2）中药药性以温、寒为主，药味以辛、甘、苦为主，归经以脾、胃、肝、肺、肾为主，使用频率较高的核心药物有人参、甘草、茯苓、白术、陈皮等24味；3）共得到4组药物聚类分析组合，C1：丁香、肉豆蔻、干姜、木香、肉桂、附子；C2：神曲、麦芽、陈皮、苍术、白术、厚朴；C3：当归、黄芪、五味子、升麻、白芍、麦冬；C4：人参、茯苓、半夏、酸枣仁。 结论古代医家治疗多寐多以脾胃为病机核心，涉及气、血、阴、阳及湿邪等多种病理证素。
Abstract:
ObjectiveTo explore the cause, pathogenesis and medication rules of somnolence in the ancient books. MethodsAfter searching the relevant statement and the prescriptions of somnolence in the ancient books, Excel and SPSS 21.0 statistical software were used to carry out frequency and cluster analysis of the cause and the pathogenesis of somnolence, the nature, flavor and meridian tropism of herbs. Results1)In the articles of ancient books, the cause and the pathogenesis of somnolence mainly were heat pathogen hurting Yin, defensive-Qi stagnating Yin, dampness encumbering due to the disease of spleen, heat in the gallbladder and excess in the liver, cardiac deficiency and delirium, and Yin disease due to Yang deficiency; 2) the medicine of TCM was primarily warm and cold, with the pungent, sweet and bitter flavor, entering the meridians of spleen, stomach, liver, lung and kidney, the core herbs with higher frequency were 24 ones including ginseng, Gancao (Glycyrrhizae radix et rhizoma), Fuling [Poria cocos（Schw.）Wol], Baizhu (Atractylodes macrocephala Koidz.) and Chenpi (Citrus reticulata Blanco); 3) Four sets of drug combination of cluster analysis were obtained, C1: Dingxiang(Caryophylli flos), Roudoukou (Myristicae semen), dried ginger, Muxiang(Aucklandiae radix), Rougui(Cinnamomi cortex), Fuzi (Aconiti lateralis radix praeparata); C2: Shenqu (medicated leaven), Maiya(Hordei fructus germinatus), Chenpi (Citrus reticulata Blanco), Cangzhu(Atractylodis rhizoma), Baizhu (Atractylodes macrocephala Koidz.); C3: Danggui (Angelicae sinensis radix), Huangqi (Astragali radix), Wuweizi(Schisandrae chinensis fructus), Shengma(Cimicifugae rhizoma), Baishao (Paeoniae radix alba), Maidong (Ophiopogonis radix); C4: ginseng, Fuling, Banxia (Pinelliae rhizoma) and Suanzaoren(Ziziphi spinosae semen). ConclusionAncient doctors mostly take spleen and stomach as the core of the pathogenesis in the treatment of somnolence, involving many kinds of pathological syndrome elements: Qi, blood, Yin, Yang and damp evil.

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备注/Memo

备注/Memo:
罗乐（1996—），女，在读硕士研究生。研究方向：睡眠医学。北京市自然科学基金（7162049）。
更新日期/Last Update: 2023-05-15