[1]陆景荣,陆梅元,曾海生,等.基于生/醋大黄的大承气汤对实热壅滞证胎粪性腹膜炎小鼠血清ET、NO和TNF-α的影响[J].西部中医药,2024,37(01):5-8.[doi:10.12174/j.issn.2096-9600.2024.01.02]
　LU Jingrong,LU Meiyuan,ZENG Haisheng,et al.The Effects of Dachengqi Tang Based on Raw Rhubarb and Vinegar Rhubarb on Serum ET, NO and TNF-α in Mice with Faecal Peritonitis[J].Western Journal of Traditional Chinese Medicine,2024,37(01):5-8.[doi:10.12174/j.issn.2096-9600.2024.01.02]
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基于生/醋大黄的大承气汤对实热壅滞证胎粪性腹膜炎小鼠血清ET、NO和TNF-α的影响
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
37
期数:
2024年01期
页码:
5-8
栏目:
基础研究
出版日期:
2024-01-15

文章信息/Info

Title:
The Effects of Dachengqi Tang Based on Raw Rhubarb and Vinegar Rhubarb on Serum ET, NO and TNF-α in Mice with Faecal Peritonitis
作者:
陆景荣1, 陆梅元2, 曾海生3, 马秀梅1, 陈勇4, 赵凤仙4, 陈宏夏4
1.广西国际壮医医院，广西 南宁 530201
2.广西壮族自治区食品药品审评查验中心，广西 南宁 530029
3.右江民族医学院附属医院，广西 百色 533000
4.广西中医药大学，广西 南宁 530200
Author(s):
LU Jingrong1, LU Meiyuan2, ZENG Haisheng3, MA Xiumei1, CHEN Yong4, ZHAO Fengxian4, CHEN Hongxia4
1.Guangxi International Zhuang Medicine Hospital, Nanning 530201, China
2.Guangxi Food and Drug Evaluation & Inspection Center, Nanning 530029, China
3.Affiliated Hospital of Youjiang Medical University for Nationalites, Baise 533000, China
4.Guangxi University of Chinese Medicine, Nanning 530200, China
关键词:
胎粪性腹膜炎; 大承气汤; 内毒素; 一氧化氮; 肿瘤坏死因子
Keywords:
faecal peritonitis; ET; NO; TNF-
分类号:
R585.5
DOI:
10.12174/j.issn.2096-9600.2024.01.02
文献标志码:
A
摘要:
目的研究基于生/醋大黄的大承气汤对胎粪性腹膜炎（faecal peritonitis with excessive heat stagnation，ABP）小鼠血清内毒素（endotoxin，ET）、一氧化氮（nitric oxide，NO）和肿瘤坏死因子α（tumor necrosis factor α，TNF-α）的影响。 方法将105只昆明种小鼠按随机数字表法分为生/醋大黄炮制品的大承气汤组（6、10 g/kg）、阳性对照组、空白对照组及模型组，按容积20 mL/kg剂量给药后测定各组小鼠血清ET、NO和TNF-α含量。 结果生/醋大黄炮制品的大承气汤组均能增加实热壅滞证ABP小鼠血清NO含量，降低小鼠血清ET和TNF-α含量。 结论生/醋大黄炮制品的大承气汤对ABP小鼠血清ET、NO和TNF-α含量的影响可能与生/醋大黄炮制方法以及其配伍的厚朴、枳实和芒硝有关。
Abstract:
ObjectiveTo investigate the influene of Dachengqi Tang based on raw rhubarb and vinegar rhubarb on serum ET, NO and TNF-α in mice with faecal peritonitis with excessive heat stagnation (ABP). MethodsAll 105 Kunming mice were randomized into Dachengqi Tang groups of raw rhubarb and vinegar rhubarb (6 and 10 g/kg), positive control group, blank control group and the model group, dosed at 20 mL/kg by volume, to detect the contents of serum ET, NO and TNF-α in mice. ResultsDachengqi Tang groups of raw rhubarb and vinegar rhubarb could increase the contents of NO in ABP mice, decrease the contents of ET and TNF-α. ConclusionThe influence of Dachengqi Tang based on raw rhubarb and vinegar rhubarb on the contents of serum ET, NO and TNF-α in ABP mice might be related to the processings of raw and vinegar products and its combination with Houbo (Magnoliae officinalis cortex), Zhishi (Aurantii fructus immaturus) and Mangxiao (Natrii sulfas).

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备注/Memo

备注/Memo:
陆景荣（1968—），男，主管药师。研究方向：中药制剂研发。国家自然科学基金（81360524）；国家中医药管理局科研三级实验室中（壮）药化学与质量分析实验室（国中医药发2009〔21〕号）；2019年度广西高校中青年教师科研基础能力提升项目（2019KY0341）；2019年广西中医药大学青年基金项目
更新日期/Last Update: 2024-01-15