[1]张琦君,冯丽娜,李玉琴,等.肺岩宁方对老年非小细胞癌患者癌因性疲乏及T淋巴细胞、MDSCs、Tregs水平的影响[J].西部中医药,2025,38(01):43-47.[doi:10.12174/j.issn.2096-9600.2025.01.10]
　ZHANG Qijun,FENG Lina,LI Yuqin,et al.The Effects of Feiyanning Prescription on Cancer-related Fatigue, the Levels of T Lymphocytes, MDSCs and Tregs in the Elderly with NSCLC[J].Western Journal of Traditional Chinese Medicine,2025,38(01):43-47.[doi:10.12174/j.issn.2096-9600.2025.01.10]
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肺岩宁方对老年非小细胞癌患者癌因性疲乏及T淋巴细胞、MDSCs、Tregs水平的影响()
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
38
期数:
2025年01期
页码:
43-47
栏目:
博士论坛
出版日期:
2025-01-15

文章信息/Info

Title:
The Effects of Feiyanning Prescription on Cancer-related Fatigue, the Levels of T Lymphocytes, MDSCs and Tregs in the Elderly with NSCLC
作者:
张琦君1, 冯丽娜1, 李玉琴1, 邓海滨2, 沈欢2, 殷书敏2, 徐振晔2
1.上海市虹口区江湾医院/上海健康医学院附属第一康复医院，上海 200081
2.上海中医药大学附属龙华医院，上海 200032
Author(s):
ZHANG Qijun1, FENG Lina1, LI Yuqin1, DENG Haibin2, SHEN Huan2, YIN Shumin2, XU Zhenye2
1.Jiangwan Hospital of Hongkou District of Shanghai / The First Affiliated Rehabilitation Hospital of Shanghai University of Medicine ＆ Health Sciences, Shanghai 200081, China
2.Longhua Hospital Shanghai University of TCM, Shanghai 200032, China
关键词:
非小细胞肺癌; 癌因性疲乏; 肺岩宁方; 髓源性抑制细胞; T细胞
Keywords:
non-small cell lung cancer; cancer-related fatigue; prescription; MDSCs; T lymphocytes
分类号:
R273
DOI:
10.12174/j.issn.2096-9600.2025.01.10
文献标志码:
B
摘要:
目的观察肺岩宁方对老年非小细胞肺癌（non-small cell lung cancer，NSCLC）患者癌因性疲乏及T淋巴细胞、髓源性抑制细胞（myeloid-derived suppressor cells，MDSCs）、调节性T细胞（regulatory T cells，Tregs）水平的影响。 方法将75例老年NSCLC患者随机分为对照组（38例）和治疗组（37例）。对照组给予康艾注射液静脉滴注等基础治疗，治疗组在对照组的基础上给予口服肺岩宁方治疗，4周为1疗程，治疗3个疗程。观察两组疲乏量表评分（piper fatigue scale，PFS）、卡氏评分（Karnofsky，KPS）、生存质量有效率、症状积分、中医证候疗效、外周血中T淋巴细胞、MDSCs及Tregs水平的变化。 结果两组治疗后PFS各维度评分均降低，KPS评分升高（P＜0.05）；治疗组治疗后PFS各维度评分均低于对照组（P＜0.05），KPS评分高于对照组（P＜0.05）。生存质量总有效率治疗组［89.2%（33/37）］高于对照组［81.6%（31/38）］，但差异无统计学意义（P＞0.05）。两组治疗后症状积分均降低（P＜0.05）；治疗组治疗后症状评分均低于对照组（P＜0.05）。中医证候疗效总有效率治疗组［91.9%（34/37）］高于对照组［65.8%（25/38）］（P＜0.05）。两组治疗后CD3+、CD4+、CD4+/CD8+水平均升高（P＜0.05），MDSCs、Tregs水平均降低（P＜0.05）；治疗组治疗后CD3+、CD4+、CD8+水平均高于对照组（P＜0.05），MDSCs、Tregs水平均低于对照组（P＜0.05）。 结论肺岩宁方联合康艾注射液可改善老年NSCLC患者癌因性疲乏及生存质量，提高患者免疫功能，其机制与抑制MDSCs、Tregs，提高T淋巴细胞水平，改善肿瘤免疫抑制有关。
Abstract:
ObjectiveTo observe the effects of Feiyanning prescription on cancer-related fatigue (CRF), the levels of T lymphocytes, MDSCs and Tregs in the elderly with non-small cell lung cancer (NSCLC). MethodsA total of 75 senile NSCLC patients were randomized into 38 cases in the control group and 37 cases in the treatment group. The control group accepted intravenous dripping of Kang’ai Injection and other basic therapies, the treatment group took Feiyanning prescription orally on the foundation of the therapy the control group received, four weeks were one course of the treatment, and all the patients were treated for three courses. To observe the scores of the piper fatigue scale (PFS), Karnofsky performance scale (KPS), the effective rate of quality of life, symptom integrals, curative effects of TCM syndromes, the levels of T lymphocytes, MDSCs and Tregs in peripheral blood between both groups. ResultsAfter the treatment, different dimensional scores of PFS were reduced while KPS scores were increased in the two groups after the treatment (P<0.05); different dimensional scores of PFS in the treatment group were lower than these of the control group after the treatment (P<0.05), KPS scores were higher than these of the control group (P<0.05). Total effective rate of quality of life of the treatment group was [89.2%(33/37)], higher than that [81.6%(31/38)] of the control group, but the difference had no statistical meaning (P<0.05). After the treatment, syndrome integrals in the two groups were evidently lowered (P<0.05); syndrome integrals of the treatment group were lower than these of the control group after the treatment (P<0.05). Total effective rate of the TCM syndrome integrals in the treatment group was [91.9%(34/37)], higher than that [65.8%(25/38)] of the control group (P<0.05). After the treatment, the levels of CD3+, CD4+ and CD4+/CD8+ were raised in the two groups (P<0.05), the levels of MDSCs and Tregs were lowered (P<0.05); the treatment group was higher than the control group in the levels of CD3+, CD4+ and CD8+(P<0.05), the levels of MDSCs and Tregs were lower than these of the control group (P<0.05). Conclusion Feiyanning prescription combined with Kang’ai injection could apparently perfect CRF and quality of life in senile NSCLC patients, raise the patients’ immunologic function, and its mechanism might be related to inhibiting MDSCs and Tregs, lifting the levels of T lymphocytes and improving the immunosuppression of tumors.

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备注/Memo

备注/Memo:
张琦君（1983—），女，博士学位，副主任医师。研究方向：中医药抗肿瘤的理论和机制研究。上海市卫生和计划生育委员会中医药科研课题（2018LP006）；上海市教育委员会科研创新计划项目（2017-01-07-00-10-E00064）；上海市虹口区卫健委中医药科研课题（HKQ-ZYY-2021-03）。
更新日期/Last Update: 2025-01-15