[1]张文娟,李江,林陶秀,等.基于网络药理学探讨琥珀散治疗子宫内膜异位症的作用机制[J].西部中医药,2025,38(02):81-86.[doi:10.12174/j.issn.2096-9600.2025.02.18]
　ZHANG Wenjuan,LI Jiang,LIN Taoxiu,et al.Network Pharmacology-based Exploration into the Mechanism of Treating Endometriosis with Amber Powder[J].Western Journal of Traditional Chinese Medicine,2025,38(02):81-86.[doi:10.12174/j.issn.2096-9600.2025.02.18]
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基于网络药理学探讨琥珀散治疗子宫内膜异位症的作用机制()
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
38
期数:
2025年02期
页码:
81-86
栏目:
二次研究
出版日期:
2025-02-15

文章信息/Info

Title:
Network Pharmacology-based Exploration into the Mechanism of Treating Endometriosis with Amber Powder
作者:
张文娟1, 李江2, 林陶秀1, 孙新慧1, 何甜甜1, 霍超越1, 马小娜1
1.北京中医药大学第三附属医院，北京 100029
2.北京中医药大学东方医院，北京 100078
Author(s):
ZHANG Wenjuan1, LI Jiang2, LIN Taoxiu1, SUN Xinhui1, HE Tiantian1, HUO Chaoyue1, MA Xiaona1
1.The Third Affiliated Hospital of Beijing University of Chinese Medicine, Beijing 100029, China
2.Dongfang Hospital of Beijing University of Chinese Medicine, Beijing 100078, China
关键词:
子宫内膜异位症; 上皮-间质转化; 琥珀散; 网络药理学; 作用机制
Keywords:
endometriosis; epithelial mesenchymal transition; amber powder; network pharmacology; mechanism
分类号:
R271.9
DOI:
10.12174/j.issn.2096-9600.2025.02.18
文献标志码:
A
摘要:
目的基于网络药理学研究琥珀散调控上皮-间质转化（epithelial mesenchymal transition，EMT）治疗子宫内膜异位症（endometriosis，EMs）的作用机制。 方法通过中药系统药理学数据库与分析平台（traditional Chinese medicine systems pharmacology database and analysis platform，TCMSP）、SwissTargetPrediction数据库检索琥珀散的活性成分及靶点；利用人类基因数据库（the human gene database，GeneCards）、在线人类孟德尔遗传数据库（online mendelian inheritance in man，OMIM）、药物靶标数据库（therapeutic targetdatabase，TTD）以及DrugBank、PharmGkb数据库检索EMs和EMT靶点，并绘制韦恩图；通过Cytoscape 3.7.2软件构建“药物-有效成分-靶点”网络；对关键靶点进行基因本体论（gene ontology，GO）和京都基因与基因组百科全书（kyoto encyclopedia of genes and genomes，KEGG）富集分析。 结果共筛出琥珀散活性成分111个，主要包括山柰酚、槲皮素、黄芩苷等；获得“药物-疾病-表型”靶点198个；GO分析发现主要生物学过程富集在细胞对氧化应激的反应、对活性氧的反应等方面；KEGG分析发现主要富集在PI3K/AKT、MAPK、HIF-1等信号通路方面。 结论琥珀散调控EMT治疗EMS的作用机制可能与其抑制黏附、侵袭、血管生成等途径有关。
Abstract:
ObjectiveTo study the mechanism of treating endometriosis (EMs) with amber (Hupo) powder via regulating epithelial mesenchymal transition (EMT) based on network pharmacology. MethodsThe active ingredients and targets of the powder were retrieved from TCMSP, SwissTargetPrediction; EMs and EMT targets were searched from GeneCards, OMIM, TTD, DrugBank and PharmGkb database, to draw venny diagrams; Cytoscape 3.7.2 software was used to build "medicine-active ingredients-targets" network; and to perform GO and KEGG enrichment analysis of the key targets. ResultsA total of 11 active ingredients of the powder were screened out, mainly containing kaempferol, quercetin and baicalin; all 198 targets of "medicine-disease-phenotype" were obtained; GO analysis displayed that the main biological processes were enriched in the response of cells to oxidative stress and reactive oxygen species; KEGG enrichment analysis indicated that the main pathways were PI3K/AKT, MAPK and HIF-1 and others. ConclusionThe mechanism of the powder in the treatment of EMS via regulating EMT might be related to its inhibition of adhesion, invasion and angiogenesis.

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备注/Memo

备注/Memo:
张文娟（1995—），女，硕士学位。研究方向：子宫内膜异位症的中西医结合防治。国家自然科学基金面上项目（81973895）。
更新日期/Last Update: 2025-02-15