[1]陈瑞,吴艳,沙娅·玛哈提.基于四君子汤联合肠内营养液对食管癌术后患者肠内营养治疗方案的研究[J].西部中医药,2025,38(03):135-138.[doi:10.12174/j.issn.2096-9600.2025.03.26]
　CHEN Rui,WU Yan,Shaya·MAHATI.Study on Enteral Nutrition Therapeutic Regimen for Patients after Esophageal Cancer Operation Based on Sijunzi Tang Combined with Enteral Nutrition Solution[J].Western Journal of Traditional Chinese Medicine,2025,38(03):135-138.[doi:10.12174/j.issn.2096-9600.2025.03.26]
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基于四君子汤联合肠内营养液对食管癌术后患者肠内营养治疗方案的研究()
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
38
期数:
2025年03期
页码:
135-138
栏目:
衷中参西
出版日期:
2025-03-15

文章信息/Info

Title:
Study on Enteral Nutrition Therapeutic Regimen for Patients after Esophageal Cancer Operation Based on Sijunzi Tang Combined with Enteral Nutrition Solution
作者:
陈瑞, 吴艳, 沙娅·玛哈提
新疆医科大学第一附属医院，新疆 乌鲁木齐 830054
Author(s):
CHEN Rui, WU Yan, Shaya·MAHATI
The First Teaching Hospital of Xinjiang Medical University, Urumqi 830054, China
关键词:
食管癌; 四君子汤; 肠内营养液; 术后康复; 肠道微生态
Keywords:
esophageal cancer; enteral nutrition solution; postoperative recovery; intestinal microecology
分类号:
R273
DOI:
10.12174/j.issn.2096-9600.2025.03.26
文献标志码:
B
摘要:
目的探索四君子汤联合肠内营养液在治疗食管癌方面的优势。 方法纳入经手术治疗的100例食管癌患者分为两组，每组50例，给予观察组四君子汤联合标准肠内营养液治疗，给予对照组肠内营养液治疗。观察并比较两组在营养指标、免疫指标、炎症指标、黏膜屏障指标和临床症状方面的差异。 结果治疗前两组各方面指标差异无统计学意义。治疗后观察组营养指标［白蛋白（albumin，Alb）、总蛋白（total protein，TP）］均有所提高，且观察组升高更明显（P＜0.05）；治疗后两组免疫指标即4型辅助性T细胞（cluster of differentiation 4 positive，CD4+）、8型辅助性T细胞（cluster of differentiation 4 positive，CD8+）、CD4/CD8比率（CD4 to CD8 Ratio，CD4+/CD8+）有所上升，观察组上升更明显（P＜0.05）；治疗后两组CD8+均有所下降，且观察组下降更明显（P＜0.05）；治疗后两组炎症指标即肿瘤坏死因子α（tumor necrosis factor-alpha，TNF-α）、白细胞介素6（interleukin-6，IL-6）、C-反应蛋白（C-reactive protein，CRP）均有所下降，观察组下降更明显（P＜0.05）；治疗后两组黏膜屏障指标即二胺氧化酶（diamine oxidase，DAO）、尿L/M（urinary lactulose/mannitol ratio，L/M）均有所下降，观察组下降更明显（P＜0.05））；观察组术后肠鸣音恢复时间、初次排气时间、初次排便时间和住院时间少于对照组（P＜0.05）；观察组术后大便中乳酸杆菌多于对照组，大肠杆菌少于对照组（P＜0.05）。 结论四君子汤联合肠内营养液可以作为治疗食管癌的有效辅助选择，可以提高术后康复水平，改善肠道微生态。
Abstract:
ObjectiveTo explore the advantages of Sijunzi Tang joined with enteral nutrition solution in the treatment of esophageal cancer. MethodsA total of 100 patients undergoing the surgical treatment were allocated to two groups with 50 cases in each group, Sijunzi Tang and standard enteral nutrition solution was given to the observation group, while enteral nutrition solution was administered to the control group. To observe and compare the differences in nutritional indexes, immunological indexes, inflammatory indicators, mucosal barrier indicators and clinical symptoms between both groups. ResultsThe difference had no statistical meaning in the indexes before the treatment between the two groups. After the treatment, the nutritional indexes of the observation group including Alb and TP were elevated, and the increase of the observation group was more evident (P<0.05); After the treatment, immunological indexes of the two groups such as CD4+, CD8+ and CD4+/CD8+ were lifted, and the increase of the observation group was more apparent (P<0.05); after the treatment, the levels of CD8+ were reduced in the two groups, and the decrease of the observation group was more obvious (P<0.05); after the treatment, the levels of inflammatory indexes including TNF-α, IL-6 and CRP were lowered in the two groups, and the reduction of the observation group was more obvious (P<0.05); mucosal barrier indicators covering DAO, L/M were lowered in the two groups after treating, and the decrease of the observation group was more noticeable (P<0.05); the observation group was less than the control group in the recovery time of bowel sounds, initial exhaust time, initial defecation time and the lengthen of hospital stay (P<0.05); more lactic acid bacteria and fewer Escherichia coli could be found in the stools of the observation group compared with the control group after the operation (P<0.05). Conclusion Sijunzi Tang joined with enteral nutrition solution served as the effective adjuvant therapy for esophageal cancer could promote the recovery after the surgery and improve intestinal microecology.

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备注/Memo

备注/Memo:
陈瑞（1980—），女，副主任护师。研究方向：肿瘤的临床护理。新疆维吾尔自治区自然科学基金（2021D01C351）。
更新日期/Last Update: 2025-03-15