[1]秦艳,李虹.丹莪妇康煎膏治疗子宫内膜异位症的疗效及其对PI3K/AKT信号通路的影响[J].西部中医药,2025,38(09):112-115.[doi:10.12174/j.issn.2096-9600.2025.09.20]
　QIN Yan,LI Hong.Clinical Effects of Dan?e Fukang Soft Extract in the Treatment of Endometriosis and Its Influence on PI3K/AKT Signaling Pathway[J].Western Journal of Traditional Chinese Medicine,2025,38(09):112-115.[doi:10.12174/j.issn.2096-9600.2025.09.20]
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丹莪妇康煎膏治疗子宫内膜异位症的疗效及其对PI3K/AKT信号通路的影响()

《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
38
期数:
2025年09期
页码:
112-115
栏目:
临床研究
出版日期:
2025-09-15

文章信息/Info

Title:
Clinical Effects of Dan?e Fukang Soft Extract in the Treatment of Endometriosis and Its Influence on PI3K/AKT Signaling Pathway
作者:
秦艳, 李虹
上海市第七人民医院妇产科，上海 200137
Author(s):
QIN Yan, LI Hong
Department of Obstetrics and Gynecology, Shanghai Seventh People’s Hospital, Shanghai 200137, China
关键词:
子宫内膜异位症; 磷脂酰肌醇3-激酶; 丹莪妇康煎膏; 米非司酮
Keywords:
endometriosis; phosphatidylinositol 3-kinase; soft extract; mifepristone
分类号:
R271.9
DOI:
10.12174/j.issn.2096-9600.2025.09.20
文献标志码:
B
摘要:
目的观察丹莪妇康煎膏治疗子宫内膜异位症的疗效，及其对磷脂酰肌醇3-激酶/蛋白激酶B（phosphatidylinositol 3-kinase/protein kinase B，PI3K/AKT）信号通路的影响。 方法将子宫内膜异位症患者96例根据计算机产生随机数分为观察组和对照组各48例。对照组予米非司酮治疗，观察组予丹莪妇康煎膏治疗。观察两组患者临床疗效及治疗前后子宫体积、子宫肌瘤体积、抗子宫内膜抗体（endometrial antibody，EmAb）、CA125、抗苗勒氏管激素（anti-Mullerian hormone，AMH）、卵泡生成激素（follicle-stimulating hormone，FSH）、收缩期峰值血流速度（peak systolic blood flow velocity，PSV）、窦状卵泡数量（antral follicle counting，AFC）、血液黏度、PI3K，AKT和血管内皮生长因子（vascular endothelial growth factor，VEGF）水平。 结果总有效率观察组为93.75%（45/48），对照组为77.08%（37/48），观察组优于对照组（χ2=4.098，P＜0.01）。治疗后两组患者子宫体积、子宫肌瘤体积、EmAb、CA125、AMH、PSV、全血高切黏度、全血低切黏度、全血还原黏度、血浆比黏度、PI3K，AKT和VEGF水平均较治疗前降低（P＜0.01），观察组低于对照组（P＜0.01）；治疗后两组患者FSH和AFC水平较治疗前升高（P＜0.01），观察组高于对照组（P＜0.01）。 结论丹莪妇康煎膏治疗子宫内膜异位症疗效优于米非司酮，而且能够改善患者卵巢功能和血液黏度，其机理与改善PI3K/AKT信号通路有关。
Abstract:
ObjectiveTo survey therapeutic effects of Dan’e Fukang soft extract in the treatment of endome-triosis, and its impacts on PI3K/AKT signaling pathway. MethodsAll 96 cases were allocated to the observation group and the control group according to random number table method with 48 cases in each group. The control group was treated with mifepristone, and the observation group orally took Dan’e Fukang soft extract. To observe clinical effects, uterine volume, the size of uterine fibroid, the levels of EmAb, CA125, AMH and FSH, PSV, AFC, blood viscosity, PI3K, AKT and VEGF before and after the treatment in the two groups. ResultsTotal effective rate of the observation group was 93.75% (45/48), higher than 77.08% (37/48) of the control group (χ2=4.098, P<0.01). After the treatment, uterine volume, the size of uterine fibroid, the levels of EmAb, CA125, AMH, PSV, whole blood high-shear viscosity, whole blood low-shear viscosity, whole blood reduced viscosity, plasma viscosity, PI3K, AKT and VEGF were lowered compared with before the treatment (P<0.01), and the observation group was lower than the control group (P<0.01); after the treatment, the levels of FSH and AFC were raised than before the treatment (P<0.01), and the observation group was higher than the control group (P<0.01). Conclusion Dan’e Fukang soft extract in the treatment of endometriosis is superior to mifepristone, it could improve ovarian function and blood viscosity, and its mechanism might be related to PI3K/AKT signaling pathway improvement.

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备注/Memo

备注/Memo:
秦艳（1986—），女，硕士学位，主治医师。研究方向：宫颈疾病和恶性肿瘤的诊治。上海市浦东新区卫生健康委员会科研项目（PW2023A-57）。
更新日期/Last Update: 2025-09-15