基于PI3K/AKT信号通路探讨中药单体治疗糖尿病心肌病的研究进展-《西部中医药》

文章信息/Info

Title:: Research Progress of Traditional Chinese Medicine Monomer in the Treatment of Diabetic Cardiomyopathy Based on PI3K/AKT Signaling Pathway

作者:: 曾奇虎^1,2, 刘孟楠^1,2, 李文龙^1,2, 唐超^1,2, 李小林^1,2, 罗钢^1,2, 白雪^1,2; 1.西南医科大学附属中医医院，四川泸州 646000
2.西南医科大学附属中医医院国家中医药临床研究基地，四川泸州 646000

Author(s):: ZENG Qihu^1,2, LIU Mengnan^1,2, LI Wenlong^1,2, TANG Chao^1,2, LI Xiaolin^1,2, LUO Gang^1,2, BAI Xue^1,2; 1.The Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou 646000, China
2.National Traditional Chinese Medicine Clinical Research Base, the Affiliated Traditional Chinese Medicine Hospital of Southwest Medical University, Luzhou 646000, China

Keywords:: diabetic cardiomyopathy; PI3K; AKT; signaling pathway; herbal monomer; TCM

摘要:: 从磷脂酰肌醇3激酶（phosphatidylinositol-3 kinase，PI3K）/蛋白激酶B（protein kinase B，AKT）信号通路的组成和功能、PI3K/AKT信号通路与糖尿病心肌病（diabetic cardiomyopathy，DCM）的关系、通过PI3K/AKT信号通路治疗DCM的中药三方面入手，综述基于PI3K/AKT信号通路中药单体治疗DCM的研究进展，指出部分中药单体可调控PI3K/AKT信号通路，发挥抗心肌细胞凋亡、降低心肌细胞氧化应激、改善心肌间质纤维化及抑制心肌炎症的药理作用，从而治疗DCM。

Abstract:: The advances in treating diabetic cardiomyopathy with herbal monomer were summarized based upon PI3K/AKT signaling pathway from the composition and function of PI3K/AKT, the connection between PI3K/AKT signaling pathway and diabetic cardiomyopathy, and herbal treatment for diabetic cardiomyopathy via PI3K/AKT signaling pathway, part of herbal monomers could regulate PI3K/AKT signaling pathway, exerting the pharmacological actions including resisting myocardial cell apoptosis, reducing myocardial oxidative stress, improving myocardial interstitial fibrosis and restraining myocardial inflammation, thereby treating diabetic cardiomyopathy.

备注/Memo:: 国家自然科学基金面上项目（82074378）；国家中医药管理局中医药创新团队及人才支持计划项目（ZYYCXTD-C-202207）；四川省中医药管理局中医药防治心脑血管疾病创新团队项目（2022C007）；西南医科大学附属中医医院中西医结合防治心脑血管疾病创新团队项目（2022-CXTD-02）；西南医科大学附属中医医院自选课题（〔2019〕119号-35）。曾奇虎（1989—），男，硕士学位，主治医师。研究方向：心血管疾病的基础与临床研究。