[1]刘应东,王翼洲.健脾益气消导方治疗糖尿病胃轻瘫的临床研究[J].西部中医药,2012,25(10):5-8.
 LIU Ying-dong,WANG Yi-zhou.Clinical Study on JianPi YiQi XiaoDaoFang in Treating Diabetic Gastroparesis[J].Western Journal of Traditional Chinese Medicine,2012,25(10):5-8.
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健脾益气消导方治疗糖尿病胃轻瘫的临床研究()
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《西部中医药》[ISSN:1006-6977/CN:61-1281/TN]

卷:
25
期数:
2012年10期
页码:
5-8
栏目:
出版日期:
2012-10-15

文章信息/Info

Title:
Clinical Study on JianPi YiQi XiaoDaoFang in Treating Diabetic Gastroparesis
文章编号:
1004-6852(2012)10-0005-04
作者:
刘应东1王翼洲2
1 安徽中医学院,安徽 合肥 230038; 2 安徽中医学院第一附属医院干部消化内科
Author(s):
LIU Ying-dong1 WANG Yi-zhou2
1  Anhui University of Traditional Chinese Medicine, Hefei 230038, China;
2  Cadre Department of Gastroenterology in the First Affiliated Hospital to Anhui University  of Traditional Chinese Medicine
关键词:
胃轻瘫糖尿病性健脾益气消导方临床研究
Keywords:
gastroparesis diabetic JianPi YiQi XiaoDaoFang clinical study
分类号:
R587.29
文献标志码:
A
摘要:
目的:观察健脾益气消导方治疗糖尿病胃轻瘫(DGP)的临床疗效。方法:将60例脾虚型DGP患者随机分为治疗组和对照组各30例,2组均给予常规西药降血糖治疗,此外,治疗组给予健脾益气消导方治疗;对照组给予枸橼酸莫沙比利治疗;2组均以4周为1个疗程。观察患者治疗前后临床症状积分、胃排空率、胃动素、空腹血糖(FPG)及早餐后2小时血糖(2 h PG)等指标的改变及不良反应发生情况。结果:治疗组和对照组总有效率分别为86.67%和70.00%,2组疗效比较有显著性差异(P<0.05),2组治疗后总症状积分、胃动素、胃排空率、FPG及2 h PG较治疗前显著改善(P<0.01),组间比较有显著性差异(P<0.01)。结论:健脾益气消导方可显著改善脾虚型DGP患者的临床症状,促进胃排空,降低血浆胃动素水平;在西药降血糖、调整饮食的基础上,能显著改善DGP患者的糖代谢紊乱状况。
Abstract:
Abstract  Objective: To investigate clinical efficacy of JianPi YiQi XiaoDaoFang in treating diabetic gastroparesis(DGP). Method: Sixty patients with DGP of spleen deficiency pattern were randomly allocated into therapy group and control group, 30 cases each group. Both groups received conventional western medicine lowering blood glucose, therapy group were treated with JianPi YiQi XiaoDaoFang; control group took mosapride citrate. One session was four weeks. Side effects and changes of clinical symptom, gastric emptying rate, motilin, fasting blood-glucose and 2hours postprandial blood-glucose were observed. Result: Total effective rates of therapy group and control group were respectively 86.67% and 70.00%, comparisons between both groups suggested remarkable difference in curative effects(P<0.05), total score of symptom, motilin, gastric emptying rate, fasting blood-glucose and 2hours postprandial blood-glucose improved more significant after treating than before(P<0.01), comparisons between both groups indicated remarkable difference (P<0.01). Conclusion: JianPi YiQi XiaoDaoFang could improve symptoms of patients with DGP of spleen deficiency pattern notably, promote gastric emptying and lower level of motilin in plasma; it also can improve remarkably disorders of glucose metabolism on the basis of western medicine lowering blood-glucose and regulating diet.

参考文献/References:

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备注/Memo

备注/Memo:
收稿日期:2012-04-16  
    *基金项目:2009年度安徽中医学院临床科学研究基金项目(编号2009LC1-008ZX)
    作者简介:刘应东(1986—),男,硕士学位。研究方向:胃肠动力学。
    △通讯作者:王翼洲(1956—),男,硕士研究生导师,硕士学位,主任医师。研究方向:胃肠动力学。
更新日期/Last Update: 2012-10-29