[1]杨世霞,刘媛,陈进凡,等.肠毒清口服液对全身炎症反应综合征大鼠炎性细胞因子的影响*[J].西部中医药,2012,25(11):22-25.
 YANG Shi-xia,LIU Yuan,CHEN Jin-fan,et al.Effects of ChangDuQing Oral Liquid on Cytokines of Rats with Systemic Inflammatory Response Syndrome[J].Western Journal of Traditional Chinese Medicine,2012,25(11):22-25.
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肠毒清口服液对全身炎症反应综合征大鼠炎性细胞因子的影响*
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
25
期数:
2012年11期
页码:
22-25
栏目:
方药·药理研究
出版日期:
2012-11-15

文章信息/Info

Title:
Effects of ChangDuQing Oral Liquid on Cytokines of Rats with Systemic Inflammatory Response Syndrome
文章编号:
1004-6852(2012)11-0022-04
作者:
杨世霞1刘媛1陈进凡1田卫花2
1 甘肃省中医院,甘肃 兰州 730050;2 甘肃省中医药研究院
Author(s):
YANG Shi-xia1 LIU Yuan1 CHEN Jin-fan1 TIAN Wei-hua2
1 Gansu Province Hospital of Traditional Chinese Medicine, Lanzhou 730050, China; 2 Gansu Province A cademy of Chinese Medicine
关键词:
全身炎症反应综合症肠毒清口服液炎性细胞因子
Keywords:
systemic inflammatory response syndrome ChangDuQing oral liquid cytokines
分类号:
R285.5
文献标志码:
A
摘要:
目的:探讨肠毒清口服液对全身炎症反应综合征(SIRS)大鼠血清及肺泡灌注液中炎性细胞因子的影响。方法:将 SD 大鼠随机分为正常组、A 模型组、A 低剂量组、A 中剂量组、A 高剂量组及 B 模型组、B 低剂量组、B 中剂量组、B 高剂量组 9 组,每组 8 只,用腹腔注射酵母多糖悬浊液(ZPS)法造 SIRS 模型,正常组、模型组及肠毒清口服液各剂量组分别给予 NS 和不同浓度肠毒清口服液灌胃,连续 3 天,2 次 / 天,末次给药后第 3天处死大鼠,检测大鼠血清及肺泡灌注液中炎性细胞因子的水平。结果:A、B 各组血清中炎性因子水平略高于正常组;A、B 模型组与低、中、高剂量组各炎性因子无统计学意义;B 低、中、高剂量组的肺泡灌注液中炎性因子水平略高于A组,但无统计学意义。结论:高剂量的肠毒清口服液可通过减轻炎性因子的释放,缓解 750 mg/kgZPS 导致的 SIRS 症状。
Abstract:
Objective: To explore the effects of ChangDuQing oral liquid on cytokines in serum and alveolar perfusate of rats with systemic inflammatory response syndrome (SIRS). Method: SD rats were randomized into normal group, A model group, A group of low dosage, A group of middle dosage, A group of high dosage, B model group, B group of low dosage, B group of middle dosage and B group of high dosage, eight rats each group. SIRS models were established through peritoneal injection with suspension of yeast polysaccharides. Normal group, model group and different dosage groups of ChangDuQing oral liquid were given with NS and different concentrations of ChangDuQing oral liquid, lavage for three consecutive days, twice each day, the rats were killed after medication by the end of the 3rd day, levels of cytokines in serum and alveolar perfusate of rats were detected. Result: Levels of cytokines in serum in A, B groups were higher than that of normal group; cytokines in A, B groups and different dosage groups demonstrated statistical meaning; levels of cytokines in alveolar perfusate of B groups of different dosages were higher than A group without statistical meaning. Conclusion: High dosage ChangDuQing oral liquid can relieve reducing and the symptoms caused by 750 mg/kg suspension of yeast polysaccharides through.

参考文献/References:

[1] 张威,秦晓丽,吴扬.SIRS 的治疗进展[J].医药与保健:下旬版,2009,17(12):229-230. [2] 吴冬梅.中医药防治 SIRS/MODS 研究进展[J].中国中医急症,2008,17(4):526-528. [3] 陈进凡,吴亮.中药“肠毒清”对全身炎症反应综合症患儿血清 IL-2、IL-6、TNF水平的影响[J].甘肃中医学院学报,2003,20(4):22-23. [4] 曾萍,杨镒宇,吴伟康,等.四逆汤对 SIRS 大鼠的早期干预[J].中国病理生理杂志,2009,25(6):1222-1224. [5] 夏肖萍,费春荣,叶爱青.葛根素对 SD 大鼠全身炎症反应综合征的治疗作用及其机制研究[J].浙江检验医学,2008,6(2):12-14. [6] 吴可人.大黄素对腹腔感染大鼠血浆白蛋白及细胞因子TNF-α、IL-6 的影响[D].杭州:浙江大学,2006:53. [7] 王文俊,姚智.大黄、丹参素对单核细胞分泌的炎性细胞因子的调节[J].中国免疫学杂志,1995,11(6):370-372. [8] 陈德昌,景炳文.大黄对危重症患者系统炎性反应治疗作用的临床研究[J].中国实用外科杂志,2002,22(12):766-768. [9] 叶再元,张勤,余建法,等.大黄素对腹腔感染大鼠血浆白蛋白及 TNF-α、IL-6 影响的实验研究[J].中国中西医结合外科杂志,2007,13(2):159-162.

相似文献/References:

[1]陈进凡,刘媛,柳渊洁,等.肠毒清口服液对全身炎症反应综合征大鼠体质量及进食量的影响[J].西部中医药,2011,24(11):10.
[2]田卫花,邢福军△,梁勤,等.肠毒清口服液对全身炎症反应综合征大鼠BNP水平的影响[J].西部中医药,2012,25(12):13.
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备注/Memo

备注/Memo:
收稿日期:2012-05-18 * 基金项目 :甘肃省科技厅基金资助项目 (编号:0921TCYA001) 作者简介:杨世霞(1977—),女,硕士学位,主治医师。研究方向:肾脏疾病的中西医结合诊治。
更新日期/Last Update: 2012-11-15