[1]陈彦文,明海霞,王强,等.岷县当归预适应对大鼠缺血-再灌注心律失常的影响*[J].西部中医药,2013,26(02):15-17.
CHEN Yanwen,MING Haixia,WANG Qiang,et al.Effects of MinXian County Angelica Pre-adaptation to the Rats with Ischemia-Reperfusion Arrhythmia[J].Western Journal of Traditional Chinese Medicine,2013,26(02):15-17.
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岷县当归预适应对大鼠缺血-再灌注心律失常的影响*
《西部中医药》[ISSN:2096-9600/CN:62-1204/R]
- 卷:
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26
- 期数:
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2013年02期
- 页码:
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15-17
- 栏目:
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- 出版日期:
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2013-02-15
文章信息/Info
- Title:
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Effects of MinXian County Angelica Pre-adaptation to the Rats with Ischemia-Reperfusion Arrhythmia
- 文章编号:
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1004-6852(2013)02-0015-03
- 作者:
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陈彦文,明海霞,王强,赵鹏,郭超,赵英
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甘肃中医学院,甘肃 兰州 730000
- Author(s):
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CHEN Yanwen, MING Haixia, WANG Qiang, ZHAO Peng, GUO Chao, ZHAO Ying
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Gansu University of Traditional Chinese Medicine, Lanzhou 730000, China
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- 关键词:
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岷县当归; T 波电压; 心电图; 心率; 心律失常; 再灌注
- Keywords:
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MinXian county angelica; T wave voltage; ECG; heart rate; arrhythmia; reperfusion
- 分类号:
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R331.3
- 文献标志码:
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A
- 摘要:
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目的:观察岷县当归预适应对大鼠心肌缺血-再灌注心律失常的保护作用。方法:腹腔注射垂体后叶素和硝酸甘油复制I/R模型,统计分析模型大鼠再灌注前后T波电压、心率变化及室性心律失常的发生率。结果:岷县当归预适应能有效降低模型大鼠T波电压的抬高程度,稳定心率,减少或防止大鼠心肌缺血再灌注室性心律失常的发生。结论:岷县当归预适应可减少或防止大鼠再灌注室性心律失常的发生,从而减轻再灌注性心肌损伤,对心肌缺血再灌注后大鼠心功能具有明显保护作用。
- Abstract:
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Objective: To observe the protection of MinXian County Angelica pre-adaptation to the rats with ischemia-reperfusion arrhythmia. Method: I/R models were established through injecting hypophysin and glyceryl trinitrate to abdominal cavity. The incidence of ventricular arrhythmia, changes of heart rate and T wave voltage in rats were analyzed statistically before and after reperfusion. Result: The pre-adaptation of MinXian County Angelica could effectively decrease the raise of T wave voltage in rat models, maintain steady heart rate and reduce or prevent the incidence of ischemia-reperfusion arrhythmia in rats. Conclusion: The pre-adaptation of MinXian County angelica could reduce or prevent the incidence of reperfusion arrhythmia in rats to alleviate myocardial damage due to reperfusion and it shows the protection to heart function of rats with myocardial ischemia-reperfusion.
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备注/Memo
- 备注/Memo:
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收稿日期:2012-09-27
* 基金项目:甘肃省教育厅基金项目(编号 044B-03)
作者简介:陈彦文(1969—),男,副教授。研究方向:心脑血管疾病的中西医结合防治。
更新日期/Last Update:
2013-02-15