[1]王晓琳,张平.黄芪饮片与黄芪配方颗粒有效成分含量比较[J].西部中医药,2017,30(02):25-27.
 WANG Xiaolin,ZHANG Ping.Comparsion of Effective Elements Contents between Slices of Prepared HuangQi and Formula Granules of HuangQi[J].Western Journal of Traditional Chinese Medicine,2017,30(02):25-27.
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黄芪饮片与黄芪配方颗粒有效成分含量比较()
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
30
期数:
2017年02期
页码:
25-27
栏目:
出版日期:
2017-02-15

文章信息/Info

Title:
Comparsion of Effective Elements Contents between Slices of Prepared HuangQi and Formula Granules of HuangQi
文章编号:
1004-6852(2017)02-0025-03
作者:
王晓琳12张平3
1 甘肃省中医院,甘肃 兰州 730050; 2 甘肃省中医药研究院; 3 甘肃省药品检验研究院
Author(s):
WANG Xiaolin1, 2, ZHANG Ping3
1 Gansu Provincial Hospital of Traditional Chinese Medicine, Lanzhou 730050, China; 2 Gansu Provincial Academy of Chinese Medicine; 3 Gansu Provincial Institute for Drug Control
关键词:
黄芪饮片黄芪配方颗粒黄芪甲苷毛蕊异黄酮葡萄糖苷含量测定
Keywords:
slices of prepared HuangQi formula granules of HuangQi astragaloside Calycosin-7-glucoside content measurement
分类号:
R284.2
文献标志码:
A
摘要:
目的:比较黄芪饮片及其配方颗粒中2种有效成分的含量。方法:采用HPLC法,迪马C18色谱柱(4.6mm×250mm,5 μm),以乙腈∶水(32∶68)为流动相;蒸发光检测器检测黄芪甲苷含量,以乙腈为流动相A,以0.2%甲酸溶液为流动相B,进行梯度洗脱紫外检测器检测毛蕊异黄酮葡萄糖苷含量,比较黄芪饮片及其配方颗粒中二者含量差异。结果:黄芪饮片中2种有效成分含量均高于《中国药典》标准,黄芪配方颗粒中黄芪甲苷含量接近药典标准、毛蕊异黄酮葡萄糖苷含量与所标示的浓缩倍数不符,远低于药材含量。结论:配方颗粒生产工艺及质控标准需要改进,需建立统一的配方颗粒工艺标准和质量标准。
Abstract:
Objective: To compare the contents of two effective elements between slices of prepared HuangQi and formula granules of HuangQi (astragalus membranaceus). Methods: HPLC was adpoted, Dikma C18 chromatographic column(4.6 mm×250 mm, 5 μm) and the ratio between acetonitrile and water(32∶68) were moving phase; astragaloside contents were measured by ESLD, acetonitrile was moving phase A, 0.2% formate solution was moving B, the contents of Calycosin-7-glucoside was detected by gradient elute ultraviolet ray instrument, content differences between slices of prepared HuangQi and formula granules of HuangQi were compared. Results: The contents of two effective elements in slices of prepared HuangQi were higher than standard of Chinese pharmacopoeia, astragaloside in formula granules of HuangQi were similar to standard of Chinese pharmacopoeia, the contents of Calycosin-7-glucoside were not meet indicated concertration times, lower than the medicine contents. Conclusion: Processing methods of formula granules and quality standard need to be improved, which need to establish united processing standard and quality standard of formula granules.

备注/Memo

备注/Memo:
收稿日期:2016-10-20作者简介:王晓琳(1983—),女,硕士学位,主管中药师。研究方向:中药制剂质量标准研究。
更新日期/Last Update: 2017-02-15