[1]郭智钰,滕羽鸥,曹天雨,等.活血化瘀法联合常规疗法治疗脑心综合征的Meta分析[J].西部中医药,2021,34(12):67-73.[doi:10.12174/j.issn.2096-9600.2021.12.18]
　GUO Zhiyu,TENG Yuou,CAO Tianyu,et al.Meta-analysis of Treating Cerebral-cardiac Syndrome by Blood-activating Stasis-removing Method and Conventional Therapy[J].Western Journal of Traditional Chinese Medicine,2021,34(12):67-73.[doi:10.12174/j.issn.2096-9600.2021.12.18]
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活血化瘀法联合常规疗法治疗脑心综合征的Meta分析
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
34
期数:
2021年12期
页码:
67-73
栏目:
出版日期:
2021-12-15

文章信息/Info

Title:
Meta-analysis of Treating Cerebral-cardiac Syndrome by Blood-activating Stasis-removing Method and Conventional Therapy
作者:
郭智钰1, 滕羽鸥1, 曹天雨1, 任俊逸2, 王梓亭3, 孟伟1
1.北京中医药大学东直门医院，北京 100700
2.北京中医药大学
3.卡罗林斯卡医学院环境医学院
Author(s):
GUO Zhiyu1, TENG Yuou1, CAO Tianyu1, REN Junyi2, WANG Ziting3, MENG Wei1
1.Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing 100700, China
2.Beijing University of Chinese Medicine
3.Department of Environmental Medicine, Karolinska Institutet
关键词:
脑心综合征; 活血化瘀法; 中医药; 随机对照试验; Meta分析
Keywords:
CCS; blood-activating stasis-removing method; TCM; randomized controlled trials; Meta analysis
分类号:
R825.4
DOI:
10.12174/j.issn.2096-9600.2021.12.18
文献标志码:
A
摘要:
目的系统评价活血化瘀法联合现代医学常规疗法治疗脑心综合征（cerebral-cardiac syndrome，CCS）的疗效及安全性。 方法计算机检索CNKI、WanFang Data、CBM、PubMed、EMbase数据库，搜集中英文公开发表的关于联合中医活血化瘀法治疗脑心综合征的随机对照试验，检索时限从建库至2020年8月。采用Revman 5.3软件对纳入研究的患者临床疗效、心电图指标、神经功能缺损评分及安全性进行Meta分析。 结果共纳入25项研究，共2936例受试者，其中联合活血化瘀法研究组1459例，对照组1477例。与对照组相比，研究组临床疗效更显著（RR=1.26，95%CI［1.21，1.30］，P＜0.000 01）。研究组心电图指标：心律失常率（RR=0.41，95%CI［0.32，0.52］，P＜0.000 01），ST-T异常率（RR=0.34，95%CI［0.27，0.42］，P＜0.000 01），心肌酶水平（RR=0.37，95%CI［0.21，0.66］，P=0.000 8）有更明显的改善；心功能水平（RR=0.40，95%CI［0.16，1.00］，P=0.05）未见明显差异。研究组神经功能缺损评分（MD=-4.43，95%CI［-6.27，-2.59］，P＜0.000 01）改善但异质性高。在安全性方面，研究组不良反应发生率均低于对照组。 结论中医活血化瘀法联合常规疗法治疗CCS能够提高临床有效性，改善患者的心电图指标及心肌酶水平，在改善心脏功能方面获益，且可能降低不良事件发生率，但神经功能方面是否获益有待进一步研究。
Abstract:
ObjectiveTo systematically evaluate clinical effects of blood-activating stasis-removing method and conventional therapy of modern medicine in the treatment of CCS and its safety. MethodsRandomized controlled trials published in Chinese and English on the treatment of CCS combined with TCM blood-activating method were collected from CNKI, Wanfang data, CBM, PubMed and EMbase databases using computer, and retrieval time limit was from the establishment of the database to August 2020. Software Revman 5.3 was used to perform the meta analysis of clinical effects for the patients included in the study, ECG indexes, neurological deficit score and safety. ResultsA total of 25 studies were included, involving 2936 subjects, among which, 1459 cases in the study group of combined method of blood-activating stasis-removing and 1477 cases in the control group. Compared with the control group, clinical effects of the study group was more notable (RR=1.26, 95%CI[1.21,1.30], P<0.000 01). ECG indexes of the study group: arrhythmia rate (RR=0.41, 95%CI[0.32, 0.52], P<0.00001), ST-T abnormal rate (RR=0.34, 95%CI[0.27, 0.42], P<0.000 01), myocardial enzyme level (RR=0.37, 95%CI[0.21, 0.66], P=0.0008), showed more obvious improvements; cardiac function level (RR=0.40, 95%CI[0.16, 1.00], P=0.05) indicated no obvious difference. Neurological deficit score (MD=-4.43, 95%CI[-6.27, -2.59], P<0.000 01) of the study group was improved but highly heterogeneous. As for the safety, the study group was lower than the control group in the incidence of adverse reaction. ConclusionTCM blood-activating stasis-removing method and conventional therapy in the treatment of CCS could lift clinical effectiveness, improve ECG indexes and myocardial enzyme level , it is beneficial in improving cardiac function and may reduce the incidence of adverse events, but whether it is beneficial in neurological function remains to be further studied.

相似文献/References:

[1]李仕妹.桃红四物汤合半夏白术天麻汤治疗急性脑梗死并发脑心综合征60例[J].西部中医药,2017,30(08):77.
　LI Shimei.TaoHong SiWu Tang Combined with BanXia BaiZhu TianMa Tang in Treating 60 Cases of Acute Cerebral Infarction Complicated with Cerebrocardiac Syndrome[J].Western Journal of Traditional Chinese Medicine,2017,30(12):77.

备注/Memo

备注/Memo:
郭智钰（1994—），女，硕士学位。研究方向：心血管疾病的中西医结合防治。
更新日期/Last Update: 2021-12-15