[1]王健,李雅茜,王洪斌.甘麦大枣汤联合艾司西酞普兰治疗抑郁症的疗效及安全性观察[J].西部中医药,2022,35(07):76-79.[doi:10.12174/j.issn.2096-9600.2022.07.20]
 WANG Jian,LI Yaqian,WANG Hongbin.Clinical Effects of Ganmai Dazao Tang and Escitalopram in the Treatment of Depression and the Analysis of Its Safety[J].Western Journal of Traditional Chinese Medicine,2022,35(07):76-79.[doi:10.12174/j.issn.2096-9600.2022.07.20]
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甘麦大枣汤联合艾司西酞普兰治疗抑郁症的疗效及安全性观察
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
35
期数:
2022年07期
页码:
76-79
栏目:
衷中参西
出版日期:
2022-07-15

文章信息/Info

Title:
Clinical Effects of Ganmai Dazao Tang and Escitalopram in the Treatment of Depression and the Analysis of Its Safety
作者:
王健 李雅茜 王洪斌
鞍山市精神卫生中心心理科,辽宁 鞍山 114000
Author(s):
WANG Jian LI Yaqian WANG Hongbin
Psychology Department, Anshan Mental Health Center, Anshan 114000, China
关键词:
抑郁症安全性甘麦大枣汤艾司西酞普兰临床观察
Keywords:
depressionsafetyescitalopramclinical observation
分类号:
R277.7
DOI:
10.12174/j.issn.2096-9600.2022.07.20
文献标志码:
B
摘要:
目的观察甘麦大枣汤联合艾司西酞普兰治疗抑郁症的疗效及安全性。 方法将抑郁症患者80例根据入院顺序经随机数字表法分为两组各40例,对照组予艾司西酞普兰治疗,研究组在对照组治疗的基础上口服甘麦大枣汤,观察两组患者总有效率、汉密尔顿抑郁量表((Hamilton depression scale,HAMD)及汉密尔顿焦虑量表(Hamilton anxiety scale,HAMA)评分、交感神经皮肤反应(sympathetic skin response,SSR)的起始波潜伏期和波幅变化情况及不良反应发生率。 结果总有效率研究组为95.00%(38/40),高于对照组的77.50%(31/40)(P<0.05);治疗后两组患者HAMD、HAMA评分均较治疗前降低,且研究组低于对照组,差异具有统计学意义(P<0.05);治疗后两组患者SSR起始波潜伏期均较治疗前缩短,研究组短于对照组,波幅均较治疗前增大,研究组大于对照组,差异均具有统计学意义(P<0.05);两组患者不良反应发生率比较差异无统计学意义(P>0.05)。 结论甘麦大枣汤联合艾司西酞普兰治疗抑郁症效果优于艾司西酞普兰,且安全性较高。
Abstract:
ObjectiveTo observe clinical effects and the safety of Ganmai Dazao Tang and escitalopram in the treatment of depression. MethodsEighty patients were divided into two groups according to admission order via random number table method, the control group was treated by escitalopram, and the study group took Ganmai Dazao Tang based on Western medicine, to compare total effective rate, HAMD scores, HAMA scores, initial wave latency and amplitude variation of sympathetic skin response (SSR) and the incidence of adverse reaction between both groups. ResultsTotal effective rate of the study group was 95.00% (38/40), higher than 77.50% (31/40) of the control group (P<0.05); after treatment, HAMD and HAMA scores of both groups lowered compared with these before treatment, and the study group was lower than the control group, and the difference had statistical meaning (P<0.05); initial wave latency of SSR in both groups after the treatment shortened compared with that before treatment, the study group was shorter than the control group, the amplitude of the wave increased compared with that before treatment, the study group was greater than the control group, and the difference was statistically significant (P<0.05); there was no significant difference in the incidence of adverse reactions between both groups (P>0.05). ConclusionGanmai Dazao Tang and escitalopram in the treatment of depression are better than escitalopram with higher safety.

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备注/Memo

备注/Memo:
王健(1968—),女,副主任医师。研究方向:心理学。辽宁省鞍山市继续医学教育项目(030901)。
更新日期/Last Update: 2022-07-15