半夏泻心汤加减对幽门螺旋杆菌相关性萎缩性胃炎患者胃泌素、胃蛋白酶的影响-《西部中医药》

文章信息/Info

Title:: Effects of Modified Banxia Xiexin Tang on Gastrin and Pepsin in Patients with Helicobacter pylori Associated Atrophic Gastritis

Author(s):: LI Jing, WANG Jiehong; Shaanxi University of Chinese Medicine, Xianyang 712000, China

Keywords:: atrophic gastritis; Helicobacter pylori; gastrin; pepsin; modified

摘要:: 目的探讨半夏泻心汤加减对幽门螺旋杆菌（helicobacter pylori，Hp）相关性萎缩性胃炎患者胃泌素（gastrin，GA）及胃蛋白酶（pepsin，PG）的影响。方法将82例Hp相关萎缩性胃炎患者分为观察组和对照组各41例。对照组给予常规西医四联方案治疗，观察组给予半夏泻心汤加减治疗。连续治疗2周后观察两组患者临床疗效、中医证候评分、胃泌素17（Gastrin-17，G-17）、胃蛋白酶Ⅰ（pepsin Ⅰ，PG-Ⅰ）、胃蛋白酶Ⅱ（pepsin Ⅱ，PG-Ⅱ）、白细胞介素6（interleukin-6，IL-6）、血清C反应蛋白（C-reaction protein，CRP）、单核细胞趋化蛋白1（monocyte chemoattractant protein 1，MCP-1）及不良反应发生率等。结果观察组总有效率为90.24%（37/41），高于对照组的73.17%（30/41）（P＜0.05）。治疗后观察组患者脘腹胀痛、恶心呕吐、反酸、嗳气等评分及PG-I、PG-Ⅱ水平与IL-6、CRP、MCP-1水平均低于对照组（P＜0.05），G-17水平高于对照组。不良反应发生率观察组为14.63%（6/41），对照组为9.76%（4/41），两组比较差异无统计学意义（P＞0.05）。结论半夏泻心汤加减治疗可改善Hp相关性萎缩性胃炎患者中医证候、GA、胃蛋白酶等血清学指标水平，效果优于常规西医四联方案治疗。

Abstract:: ObjectiveTo survey the effects of modified Banxia Xiexin Tang on GA and PG in patients with Hp associated atrophic gastritis. MethodsAll 82 patients with Hp associated atrophic gastritis were divided into the observation group and the control group, with 41 cases in each group. The control group was given conventional quadruple therapy of Western medicine, and the observation group was treated with modified Banxia Xiexin Tang. To observe clinical effects, TCM syndrome integrals, G-17, PG-Ⅰ, PG-Ⅱ, IL-6, CRP and MCP-1, and the incidence of adverse reaction between both groups after two weeks of treatment consecutively. ResultsTotal effective rate of the observation group was 90.24% (37/41), higher than 73.17% (30/41) of the control group (P<0.05). After the treatment, the observation group was lower than the control group in the scores of abdominal distension and pain, nausea and vomiting, sour regurgitation and belching, the levels of PG-Ⅰ, PG-Ⅱ, IL-6, CRP and MCP-1 (P<0.05), higher than the control group in the levels of G-17. The incidence of adverse reaction of the observation group was 14.63% (6/41), higher than 9.76%(4/41) of the control group, and the difference had no statistical meaning (P>0.05). ConclusionModified Banxia Xiexin Tang could improve TCM syndromes, GA and PG in patients with Hp associated atrophic gastritis, and its effects superior to these of conventional quadruple therapy of Western medicine.