[1]东红.中风膏对动脉粥样硬化模型家兔血脂水平、血管内皮功能的影响*[J].西部中医药,2013,26(03):25-28.
　DONG Hong.Effects of ZhongFengGao on Level of Blood Fat and Vascular Endothelial Function of Rabbits with Atherosclerosis[J].Western Journal of Traditional Chinese Medicine,2013,26(03):25-28.
点击复制

中风膏对动脉粥样硬化模型家兔血脂水平、血管内皮功能的影响*
分享到：

《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
26
期数:
2013年03期
页码:
25-28
栏目:
出版日期:
2013-03-15

文章信息/Info

Title:
Effects of ZhongFengGao on Level of Blood Fat and Vascular Endothelial Function of Rabbits with Atherosclerosis
文章编号:
1004-6852(2013)03-0025-04
作者:
东红
甘肃省中医院，甘肃 兰州 730050
Author(s):
DONG Hong
Gansu Province Hospital of Traditional Chinese Medicine, Lanzhou 730050, China
关键词:
中风膏; 动脉粥样硬化; 血脂水平; ET-1、NO 含量; 辛伐他汀; 家兔
Keywords:
ZhongFengGao;  atherosclerosis (AS);  level of blood fat;  ET-1;  content of NO;  simvastatin;  rabbit
分类号:
R285.5
文献标志码:
A
摘要:
目的：探讨中风膏对动脉粥样硬化(atherosclerosis，AS )家兔模型的作用机制。方法：将 50只家兔随机分为空白对照组、动脉粥样硬化模型组(AS 组)，中风膏低、高剂量组，辛伐他汀组。除空白对照组外其余各组采用高胆固醇饲料喂养 8 周制备颈动脉粥样硬化家兔模型。通过全自动生化分析仪检测血清 TC、TG、LDL-c 含量；分光光度计检测血清 NO 含量、放射免疫法检测血清 ET-1 含量；颈动脉组织切片 HE 染色，光 镜观察动脉粥样硬化形态学。结果：AS 组家兔血清 TC、TG、LDL-c 含量明显高于空白对照组（P＜0.05）。病理形态学显示 AS 组颈动脉壁多处出现典型粥样斑块，而空白对照组无异常变化，表明动脉粥样硬化模型复制成功；中风膏高、低剂量组，辛伐他汀组血清 TG、TC、LDL-c、ET-1 含量均降低，NO 升高，与空白对照组相比有明显差异（P＜0.05）。中风膏高剂量组、辛伐他汀组中动脉粥样硬化家兔模型的斑块形态、斑块面积均较空白对照组和中风膏小剂量组明显改善（P＜0.05）。结论：中风膏能明显降低 AS 家兔模型血清 TC、TG、HDL-c、ET-1 水平，升高 NO 水平，从而达到保护血管内皮细胞、抗动脉粥样硬化的作用。
Abstract:
Objective: To explore the mechanism of ZhongFengGao on rabbits with atherosclerosis (AS).Method: All 50 rabbits were randomized into blank control group, model group, low and high dose groups of ZhongFengGao groups as well as treatment group of simvastatin. Except blank control group, other groups were fed with high cholesterol food to build the models with AS. Contents of TC, TG and LDL-c in the serum were detected with automatic biochemical analyzer; NO content was measured with spectrophotometer and ET-1 content with radioimmunoassay; tissue slice of carotid artery was stained with HE and observed under light microscope. Result:Contents of TC, TG and LDL-C in the serum of AS group were higher than that of the control group (P＜ 0.05).Pathomorphology suggested that there were typical atheromatous plaque appeared on paries carotica of AS group,there was no abnormality in the control group, which meant that the models were successfully copied. Contents of TC, TG and LDL-C in the serum decreased but NO rose in low and high dose groups of ZhongFengGao groups and treatment group of simvastatin, compared with the control group, it showed significant difference (P＜ 0.05). Shape and areas of plaque in rabbits with AS of high dose group of ZhongFengGao and treatment group of simvastatin were improved greater than that of the control group and low dose group of ZhongFengGao (P＜ 0.05). Conclusion:ZhongFengGao could obviously lower the levels of TC, TG, HDL-c and ET-1, raise NO level to protect vascular endothelial cell and against AS.

参考文献/References:

［1］ Lerman A,Edwand BS,Halltt JW，et al.Circulating and tissue endothelial immunoreactivity in advanced atherosclerosis［J］.N Eng J Med，1991，325:997. ［2］ 东红.中风膏抗脑动脉硬化 60 例临床疗效观察［J］.西部中医药，2012，25（5）：1-2. ［3］ 刘雪君，王晓萍，李妍怡.中风膏治疗缺血性脑卒中 54 例临床观察［J］.甘肃中医，2011，24（4）：52-53. ［4］ 张谦，杨瑞龙，李妍怡.中风膏对脑出血急性期大鼠炎性细胞因子的影响［J］.甘肃中医，2009，22（10）：62-64. ［5］ 李仪奎.中国药理实验方法学［M］.上海：上海科学技术出版社，1991：398. ［6］ 景冬樱.一氧化氮系统功能障碍与动脉粥样硬化［J］.中国动脉硬化杂志，1998，6(2):182-185. ［7］ 周京红.一氧化氮和动脉粥样硬化［J］.生物技术通讯，2007，18(5):879-881. ［8］ 潘雪峰，董华进，宫泽辉.内皮素与心血管功能研究的最新进展［J］.国外医学：药学分册，2007，34(1):12-17. ［9］ 刘琼，徐仓宝.血管活性物质与动脉粥样硬化［J］.宁波大学学报：理工版，2000，13(3):111-115.

相似文献/References:

[1]朱晓娜,李天浩.调脂柔脉颗粒治疗动脉粥样硬化性脑梗死的疗效评价[J].西部中医药,2012,25(10):77.
　ZHU Xiao-na,LI Tian-hao.Evaluation on Clinical Efficacy of TiaoZhi RouMai Granules in Treating Atherosclerotic Cerebral Infarction[J].Western Journal of Traditional Chinese Medicine,2012,25(03):77.
[2]刘超,李成山,李妍怡△.中风膏对缺血性脑卒中患者血小板聚集率的影响[J].西部中医药,2013,26(12):5.
　LIU Chao,LI Chengshan,LI Yanyi.Effects of ZhongFeng Ointment on Platelet Aggregation Rate of the Patients with Ischemic Stroke[J].Western Journal of Traditional Chinese Medicine,2013,26(03):5.
[3]东红.中风膏抗脑动脉硬化60例临床疗效观察[J].西部中医药,2012,25(05):1.
　DONG Hong.Curative Effects of ZhongFengGao in Treating Cerebral Arteriosclerosis: A Report of 60 Cases[J].Western Journal of Traditional Chinese Medicine,2012,25(03):1.
[4]张和平,谈建新,王敬敏,等.心脑通配方对大鼠颈总动脉粥样硬化斑块中MMP-2的影响[J].西部中医药,2014,27(03):32.
　ZHANG Heping,TAN Jianxin,WANG Jingmin,et al.Effects of XinNaoTong Prescription on MMP-2 in Carotid Atherosclerotic Plaque of Rats[J].Western Journal of Traditional Chinese Medicine,2014,27(03):32.
[5]王建平,梅妍△,李兰青,等.消脂胶囊对家兔代谢综合征动脉粥样硬化的影响[J].西部中医药,2016,29(03):14.
　WANG Jianping,MEI Yan,LI Lanqing,et al.Influence of XiaoZhi Capsules on Metabolic Syndrome Atherosclerosis of the Rabbits[J].Western Journal of Traditional Chinese Medicine,2016,29(03):14.
[6]张淑英,帅丽,张红芳,等.中药干预尿毒症血透患者CRP增高的临床疗效[J].西部中医药,2017,30(10):79.
　ZHANG Shuying,SHUAI Li,ZHANG Hongfang,et al.Clinical Effects of Herbs in Intervening CRP Rise of Uremia Patients with Hemodialysis[J].Western Journal of Traditional Chinese Medicine,2017,30(03):79.
[7]罗永苗,陈朝俊,李玥珺.基于NF-κB探讨参七脉心通胶囊抗动脉粥样硬化的作用机制[J].西部中医药,2018,31(05):8.
　LUO Yongmiao,CHEN Chaojun,LI Yuejun.Study on the Mechanism of ShenQi MaiXinTong Capsules Fighting against Atherosclerosis Based on NF-κB[J].Western Journal of Traditional Chinese Medicine,2018,31(03):8.
[8]王晓萍,杜改焕,曹骅.中风膏对颈动脉粥样硬化患者血清炎性细胞因子及颈动脉内膜中层厚度的影响[J].西部中医药,2018,31(06):6.
　WANG Xiaoping,DU Gaihuan,CAO Hua.Effects of Stroke Ointment on Inflammatory Cytokines and Carotid intima-media Thickness of the Patients with Carotid Atherosclerosis[J].Western Journal of Traditional Chinese Medicine,2018,31(03):6.
[9]于妍,杨阿妮.芪乌调脂颗粒稳定大鼠动脉粥样硬化斑块的作用机制[J].西部中医药,2018,31(07):17.
　YU Yan,YANG Ani.The Mechanism of QiWu TiaoZhi Granules Stabilizing Atheroslcerotic Plaque of the Rats[J].Western Journal of Traditional Chinese Medicine,2018,31(03):17.
[10]刘云,董剑廷△.中西医结合治疗急性心肌梗死心绞痛临床观察[J].西部中医药,2019,32(01):83.
　LIU Yun,DONG Jianting.Clinical Observation on Integrative Medicine in Treating Acute Myocardial Infarction Angina Pectoris[J].Western Journal of Traditional Chinese Medicine,2019,32(03):83.

备注/Memo

备注/Memo:
收稿日期：2012-09-28 * 基金项目：甘肃省技术研究与开发专项计划项目（编号0912TCYA014） 作者简介：东红（1969—），女，主任医师。研究方向：脑血管疾病的中西医诊治。
更新日期/Last Update: 2013-03-15