[1]杨长生,吴红彦△,李海龙,等.黑逍遥散对阿尔茨海默病模型大鼠行为学及血清肿瘤坏死因子α及白细胞介素-6和-1β的影响*[J].西部中医药,2015,28(02):10-12.
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黑逍遥散对阿尔茨海默病模型大鼠行为学及血清肿瘤坏死因子α及白细胞介素-6和-1β的影响*
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
28
期数:
2015年02期
页码:
10-12
栏目:
出版日期:
2015-02-15

文章信息/Info

文章编号:
1004-6852(2015)02-0010-03
作者:
杨长生吴红彦△李海龙容倩倩
甘肃中医学院,甘肃 兰州 730000
关键词:
阿尔茨海默病黑逍遥散炎性因子
分类号:
R285.6
摘要:
目的:观察黑逍遥散对β-淀粉样蛋白(Aβ25-35)所致阿尔茨海默病(Alzheimer disease,AD)模型大鼠血清肿瘤坏死因子(TNF-α)、白细胞介素(IL-6、IL-1β)表达的影响,探讨黑逍遥散防治AD的作用机制。方法:海马区注射Aβ25-35建立AD大鼠模型,用黑逍遥散、石杉碱甲进行对抗治疗,第28天取血清,通过酶联免疫吸附法(ELISA)测定AD大鼠血清TNF-α、IL-6、IL-1β含量。结果:模型组大鼠血清中TNF-α、IL-6、IL-1β含量显著升高,各治疗组大鼠血清TNF-α、IL-6、IL-1β含量均有所降低,黑逍遥散高剂量组大鼠血清TNF-α、IL-6、IL-1β含量显著降低。结论:有效控制AD患者体内炎性因子表达是黑逍遥散的重要作用机制。

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备注/Memo

备注/Memo:
*基金项目:国家自然科学基金项目(编号81060284)。作者简介:杨长生(1983—)女,在读硕士研究生。研究方向:方剂作用机理及药效基础物质研究。△通讯作者:吴红彦(1963—)男,教授。研究方向:方剂药理与新药开发。
更新日期/Last Update: 2015-02-15