[1]赵肖帆,先小乐,牛家瑜,等.基于“整体功能代偿疗法”探讨增强肝的代偿功能对慢性肾衰模型大鼠肾功能的影响[J].西部中医药,2017,30(10):16-18.
　ZHAO Xiaofan,XIAN Xiaole,NIU Jiayu,et al.Discussion on the Effects of Enhancing Liver Compensatory Function on Renal Function of the Rats with Chronic Renal Failure based on Wholistic Functional Compensatory Therapy[J].Western Journal of Traditional Chinese Medicine,2017,30(10):16-18.
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基于“整体功能代偿疗法”探讨增强肝的代偿功能对慢性肾衰模型大鼠肾功能的影响()
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
30
期数:
2017年10期
页码:
16-18
栏目:
出版日期:
2017-10-15

文章信息/Info

Title:
Discussion on the Effects of Enhancing Liver Compensatory Function on Renal Function of the Rats with Chronic Renal Failure based on Wholistic Functional Compensatory Therapy
文章编号:
1004-6852(2017)10-0016-03
作者:
赵肖帆，先小乐，牛家瑜，高 黎，肖相如
北京中医药大学，北京 100029
Author(s):
ZHAO Xiaofan, XIAN Xiaole, NIU Jiayu, GAO Li, XIAO Xiangru△
Beijing University of Traditional Chinese Medicine, Beijing 100029, China
关键词:
慢性肾衰整体功能代偿疗法; 慢性肾衰; 肝代偿; 四逆散; 肾功能指标
Keywords:
wholistic functional compensatory therapy for chronic renal failure;  chronic renal failure;  hepatic compensation;  SiNi powder;  renal function index
分类号:
R363.2+2
文献标志码:
A
摘要:
目的：基于“整体功能代偿疗法”探讨增强肝的代偿功能对慢性肾衰模型大鼠肾功能指标的影响。方法：将40只健康雄性Wistar大鼠随机分为4组，即模型组、空白组、四逆散组及西药福辛普利组，对给药后的中药组与模型组进行对照，观察其血肌酐(Scr)、尿素氮(BUN)指标的变化。结果：实验第8周末四逆散组与模型组比较，血清Scr、BUN水平降低(P＜0.05)，说明四逆散组在降低大鼠血清Scr、BUN，保护肾功能方面有一定作用。结论：基于“整体功能代偿疗法”增强肝的代偿功能可降低腺嘌呤致慢性肾衰模型大鼠血清Scr、BUN水平，并减轻腺嘌呤对肾脏组织损害的作用，延长慢性肾衰模型大鼠的治疗周期，缓解肾功能衰竭的进展。
Abstract:
Objective: To explore the effect of enhancing liver compensatory function on renal function index of the rats with chronic renal failure based on wholistic functional compensatory therapy. Methods: Forty healthy male Wistar rats were randomly divided into four groups, the model group, the blank group, the SiNi powder group and the Western medicine group of fosinopril. The changes of blood Scr and BUN indexes were observed when the herbal group after medication was compared with the model group. Results: By the end of the eighth week in the experiment, the levels of serum Scr and BUN of decreased when the SiNi powder group was compared with the model group(P＜0.05), which indicated that SiNi powder showed certain functions of lowering the levels of serum Scr and BUN as well as protecting renal function of the rats. Conclusion: Enhancing liver compensatory function based on wholistic functional compensatory therapy can reduce the levels of serum Scr and BUN of rat model with chronic renal failure induced by low adenine, alleviate the damage of adenine to renal tissue and prolong the treatment cycle of model rats with chronic renal failure as well as relieve the progress of their renal failure.

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备注/Memo

备注/Memo:
收稿日期：2016-11-05 *基金项目：北京中医药大学校级研究生自主课题(编号 2013-JYBZZ-XS-034)。 作者简介：赵肖帆(1989—)，男，在读硕士研究生。研究方向：经方论治肾病。
更新日期/Last Update: 2017-10-15