[1]吾斯曼·艾海提,玉苏甫·吐尔逊,吾甫尔·依马尔△.维药孜亚比提片对2型糖尿病大鼠免疫功能的影响[J].西部中医药,2017,30(11):85-87.
　Osman·Ahait,Yusup·Tursun,Wufuer·Yimaer.Effects of the Uygur Medicine Ziyabiti Tablets on the Immunologic Function of the Rats with Type Two Diabetes Mellitus[J].Western Journal of Traditional Chinese Medicine,2017,30(11):85-87.
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维药孜亚比提片对2型糖尿病大鼠免疫功能的影响()
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
30
期数:
2017年11期
页码:
85-87
栏目:
出版日期:
2017-11-15

文章信息/Info

Title:
Effects of the Uygur Medicine Ziyabiti Tablets on the Immunologic Function of the Rats with Type Two Diabetes Mellitus
文章编号:
1004-6852(2017)11-0085-03
作者:
吾斯曼·艾海提1，玉苏甫·吐尔逊2，吾甫尔·依马尔1△
1 新疆医科大学第一附属医院，新疆 乌鲁木齐 830054； 2 新疆维吾尔自治区人民医院
Author(s):
Osman·Ahait1, Yusup·Tursun2, Wufuer·Yimaer1△
1 The First Affiliated Hospital, Xinjiang Medical University, Urumqi 830054, China 2 Xinjiang Uygur Autonomous Region People′s Hospital
关键词:
2型糖尿病; 免疫功能; 孜亚比提片; 链脲佐菌素; 大鼠
Keywords:
type 2 diabetes mellitus;  immunologic function;  Ziyabiti tablets;  streptozotocin;  rats
分类号:
R285.6
摘要:
目的：探讨维药孜亚比提片对2型糖尿病大鼠免疫功能的影响。方法：将SD大鼠75只随机分为正常组15只，造模组60只，将造模组大鼠采用高脂乳汁以灌胃的方式稳定饲养8周后隔3天腹腔注射链脲佐菌素(STZ)(20 mg/kg)4次建立2型糖尿病模型，并随机分为模型组、维药孜亚比提片高、中、低剂量[6.0、3.0、1.5ｇ/(kg·d)]组各15只，连续给药8周。采用酶联免疫吸附法(ELLSA)测定并大鼠血清白细胞介-2(IL-2)、白细胞介素6(IL-6)和肿瘤坏死因子α(TNF-α)含量。结果：1)与正常组比较，模型组大鼠血清IL-2含量降低、IL-6、TNF-α含量升高，差异有统计学意义(P＜0.01)；孜亚比提片高、中剂量组IL-2含量降低，IL-6、TNF-α含量升高，差异有统计学意义(P＜0.05)，孜亚比提片低剂量组IL-2含量明显降低，TNF-α含量升高，差异有统计学意义(P＜0.01)，IL-6含量升高，但差异无统计学意义(P＞0.05)。2)与模型组比较，孜亚比提片高、中剂量组IL-2含量升高，IL-6、TNF-α含量降低，差异有统计学意义(P＜0.05)，孜亚比提片低剂量组IL-2含量升高，IL-6含量降低，差异有统计学意义(P＜0.05)，TNF-α含量降低，但差异无统计学意义(P＞0.05)。结论：维药孜亚比提片能改善2型糖尿病大鼠免疫功能。
Abstract:
Objective: To study the effects of the Uygur medicine Ziyabiti tablets on the immunologic function of diabetic rats. Methods: All 75 SD rats were selected, and randomized into 15 rats in the normal group and 60 rats in the model groups, after the rats in the model group were drenched with high-fat milk for eight weeks stably, they accepted intraperitoneal injection of STZ(20 mg/kg) for four times every three days to prepare type two diabetes mellitus (T2DM) models, randomly divided into the model group, high, moderate and low dosages groups of the Uygur medicine Ziyabiti tablets [6.0, 3.0 and 1.5 g/( kg·d)], 15 rats each group, and medicated for eight weeks consecutively. The contents of serum interleukin-2(IL-2), interleukin-6 (IL-6) and tumor necrosis factor α(TNF-α) in T2DM rat models were detected by using ELISA method. Results: 1) Compared with the normal group, the cotents of IL-2 decreased, the contents of IL-6 and TNF-α raised in the rats of the model group, and the difference had statistical meaning(P＜0.01); the contents of IL-2 decreased, the contents of IL-6 and TNF-α raised in the rats of high and moderate dosages groups of Ziyabiti tablets, and the difference had statistical meaning (P＜0.05), the contents of IL-2 decreased obviously, the contents of TNF-α raised in the rats of low dosages group of Ziyabiti tablets, and the difference had statistical meaning (P＜0.01), the contents of IL-6 raised, but the difference had no statistical meaning (P＞0.05). 2) Compared with the model group, the contents of IL-2 raised, the contents of IL-6 and TNF-α decreased in the rats of high and moderate dosages groups of Ziyabiti tablets, and the difference had statistical meaning (P＜0.05), the contents of IL-2 raised, the contents of IL-6 decreased in the rats of low dosages group of Ziyabiti tablets, and the difference had statistical meaning (P＜0.05), the contents of TNF-α decreased, but the difference had no statistical meaning (P＞0.05). Conclusion: Uygur medicine Ziyabiti tablets could improve immunologic function of T2DM rats.

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备注/Memo

备注/Memo:
收稿日期：2016-08-26 *基金项目：新疆医科大学第一附属医院青年科学基金(编号2014ZRQN23)。 作者简介：吾斯曼·艾海提(1984—)，男，药师。研究方向：维药与疾病。 △通讯作者：吾甫尔·依马尔(1980—)，男，硕士学位，主治医师。研究方向：血管性疾病的维药预防与治疗。
更新日期/Last Update: 2017-11-15