[1]薛晓东,宋红霞△.消银汤对小鼠鼠尾表皮细胞分化及Th1/Th2型细胞因子的影响[J].西部中医药,2018,31(08):10-12.
　XUE Xiaodong,SONG Hongxia.Effects of XiaoYin Decoction on Th1/Th2 Type Cell Factors and Epidermal Cell Differentiation of the Tail of Psoriasis like Mice Model[J].Western Journal of Traditional Chinese Medicine,2018,31(08):10-12.
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消银汤对小鼠鼠尾表皮细胞分化及Th1/Th2型细胞因子的影响()

《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
31
期数:
2018年08期
页码:
10-12
栏目:
出版日期:
2018-08-15

文章信息/Info

Title:
Effects of XiaoYin Decoction on Th1/Th2 Type Cell Factors and Epidermal Cell Differentiation of the Tail of Psoriasis like Mice Model
文章编号:
1004-6852(2018)08-0010-03
作者:
薛晓东1，宋红霞2△
1 重庆三峡医药高等专科学校附属医院皮肤科，重庆 万州 404000； 2 重庆三峡医药高等专科学校药理教研室
Author(s):
XUE Xiaodong1, SONG Hongxia2△
1 Department of Dermatology, Affiliated Hospital to Chongqing Three Gorges Medical College, Chongqing 404000, China; 2 Department of Pharmacology, Chongqing Three Gorges Medical College
关键词:
银屑病; 消银汤; 细胞因子Th1/Th2; 干扰素-γ; 白细胞介素4
Keywords:
psoriasis;  XiaoYin decoction;  Th1/Th2 type cell factors;  INF-γ;  IL-4
分类号:
R932
文献标志码:
A
摘要:
目的：观察消银汤治疗银屑病小鼠模型的作用，并探讨其可能的作用机制。方法：建立鼠尾鳞片表皮模型，设消银汤高、中、低剂量组、甲氨蝶呤组和空白对照组，观察各组对小鼠尾部鳞片颗粒层形成的影响，并采用ELISA法检测各组小鼠血清中γ-干扰素(IFN-γ)、白介素4(IL-4)的含量。结果：小鼠尾部鳞片表皮颗粒层形成数消银汤高、中剂量组，甲氨蝶呤组与空白对照组比较，差异有统计学意义(P＜0.05)；消银汤高剂量组与甲氨蝶呤组比较，差异有统计学意义(P＜0.05)；消银汤低剂量组与甲氨蝶呤组比较，差异无统计学意义(P＞0.05)。IFN-γ、IL-4消银汤高、中、低剂量组和空白对照组比较，差异有统计学意义(P＜0.05)。消银汤高、中、低剂量组与甲氨蝶呤组比较，差异无统计学意义(P＞0.05)。结论：消银汤可能通过调节Thl/Th2细胞因子动态平衡，促进小鼠尾部表皮颗粒层细胞形成而发挥治疗作用的。
Abstract:
Objective: To observe the effects of XiaoYin decoction in treating the mice with psoriasis, and discuss its poteintial mechanism. Methods: Mouse models with tail scale epidermis were established, they were allocated to high, moderate and low dose groups of XiaoYin decoction, methotrexate group and blank control group, the effects of different groups on tail scale granular layer of the mice were observed, simultaneously, the contents of IFN-γ and IL-4 in the serum of the mice in different groups were detected by ELISA method. Results: The difference had statistical meaning in the comparisons of mice tail scale epidermal granular layer among high and moderate doses groups of XiaoYin decoction, methotrexate group and blank control group, low dose group of XiaoYin decoction (P＜0.05); when high doses group of XiaoYin decoction was compared with methotrexate group, there was a significant difference (P＜0.05); the difference had no statistical meaning in the comparisons between low dose group of XiaoYin decoction and methotrexate group (P＞0.05). The difference was statistically significant in the comparisons of the levels of IFN-γ and IL-4 when high, moderate and low dose groups of XiaoYin decoction were compared with methotrexate group and blank control group (P＜0.05). The difference had no statistical meaning when high, moderate and low dose groups of XiaoYin decoction were compared with methotrexate group (P＞0.05). Conclusion: XiaoYin decoction could play the role of therapeutic effects by regulating dynamic balance of Th1/Th2 type cell factors and promoting the formation of mice tail epidermal granular layer cells.

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备注/Memo

备注/Memo:
收稿日期：2017-12-22 *基金项目：重庆市万州区科技计划项目(编号201303042)。 作者简介：薛晓东(1981—)，男，硕士学位，主治医师。研究方向：皮肤病的中医药诊治。 △通讯作者：宋红霞(1981—)，女，硕士学位，副教授。研究方向：皮肤病的基础研究。
更新日期/Last Update: 2018-08-15