[1]王庆,李天一,陈忆莲,等.基于证素探析干燥综合征的中医证候分布规律[J].西部中医药,2018,31(09):81-86.
　WANG Qing,LI Tianyi,CHEN Yilian,et al.Exploration into TCM Syndrome Distribution Laws of Sjogren′s Syndrome Based on Syndrome Elements[J].Western Journal of Traditional Chinese Medicine,2018,31(09):81-86.
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基于证素探析干燥综合征的中医证候分布规律()
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
31
期数:
2018年09期
页码:
81-86
栏目:
出版日期:
2018-09-15

文章信息/Info

Title:
Exploration into TCM Syndrome Distribution Laws of Sjogren′s Syndrome Based on Syndrome Elements
文章编号:
1004-6852(2018)09-0081-06
作者:
王庆1，李天一2，陈忆莲2，吴国琳1△
1 浙江大学医学院附属第一医院，浙江 杭州 310003； 2 浙江中医药大学
Author(s):
WANG Qing1, LI Tianyi2, CHEN Yilian2, WU Guolin1△
1 The First Affiliated Hospital of Medical School of ZheJiang University, Hangzhou 310003, China; 2 Zhejiang Chinese Medical University
关键词:
干燥综合征; 证素; 中医证候; Meta分析; 关联规则
Keywords:
Sjogren's disease;  syndrome element;  TCM syndrome;  meta analysis;  association rules
分类号:
R593
文献标志码:
A
摘要:
目的：将文献中干燥综合征的证型分解成基本单元证素，系统分析干燥综合征的中医证候分布特征，为规范其辨证分型提供参考。方法：检索中国知网、维普、万方及PubMed等数据库近10年发表的关于干燥综合征证型研究的文献，选择临床研究中有辨证分型的文献24篇共3019例患者，用Meta分析方法合并各证素的出现率，归纳各证素的使用频率，进行关联规则分析以探讨各证素之间的相关性。结果：干燥综合征文献中病性类证素按频率大小依次是：阴虚、血瘀、气虚、（外）风、阳亢、痰、热、寒、津亏、血虚、湿、燥、阳虚、气滞、精亏；病位类证素依次是胃、肺、肝、肾、脾、经络。在给定的支持度和置信度上挖掘出11条关联规则，其中肝肾阴虚的关联度最强。结论：干燥综合征的致病机制以阴虚为本，血瘀、气虚和外风协同发病；根据频率大小和相关性分析可以组成肝肾阴虚、气阴两虚、阴虚血瘀、阴虚内热、气阴两虚血瘀等证型作为最常用辨证参考。
Abstract:
Objective: To provide the reference for the syndrome differentiation and patterns of Sjogren's syndrome (SS) by systematically evaluating the distribution of TCM syndrome of SS after dividing the patterns of SS in the papers into basic unit syndrome element. Methods: The papers about the study on the patterns of SS which were published in recent ten years were searched in CNKI, VIP, Wanfang, Pubmed and others, 24 pieces of papers, involving 3 019 patients with the description of syndrome differentiation and patterns in clinical studies were chosen, the occurrence rate of different syndrome elements were merged by meta analysis, the frequency of different syndrome elements were summed up, the connections with different syndrome elements were discussed by performing association rules. Results: Syndrome elements of the disease nature ranked in the order of the frequency: Yin deficiency, blood stasis, Qi deficiency, (external) wind, Yang hyperactivity, phlegm, heat, cold, fluid deficiency, blood deficiency, damp, dryness, Yang deficiency, Qi stagnation, essence depletion; the syndrome elements of disease location were stomach, lung, liver, kidney, spleen and meridians. All 11 items of association rules were unearthed on the given support degree and confidence level, among them, the association rules between Yin deficiency of liver and kidney were the strongest. Conclusion: Pathogenic mechanism of SS is Yin deficiency as the root cause, blood stasis, Qi deficiency and external wind intermingled; SS could be divided into the patterns of Yin deficiency of liver and kidney, dual deficiency of Qi and Yin, Yin deficiency and blood stasis, Yin deficiency and internal heat, dual deficiency of Qi and Yin and blood stasis to provide the commonly-used reference for syndrome differentiation according to the frequency and connections analysis.

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备注/Memo

备注/Memo:
收稿日期：2017-12-27 *基金项目：国家自然科学基金面上项目（编号81473604）。 作者简介：王庆(1994—)，女，在读硕士研究生。研究方向：风湿免疫疾病的中西医结合治疗。 △通讯作者：吴国琳(1972—)，男，博士学位，主任医师。研究方向：风湿免疫疾病的中西医结合治疗。
更新日期/Last Update: 2018-09-15