[1]李智勇,陈玉兴,赵自明,等.消肿止痛巴布剂的制备工艺研究[J].西部中医药,2021,34(06):32-37.[doi:10.12174/j.issn.2096-9600.2021.06.08]
　LI Zhiyong,CHEN Yuxing,ZHAO Ziming,et al.Study on the Preparation Process of Xiaozhong Zhitong Cataplasm[J].Western Journal of Traditional Chinese Medicine,2021,34(06):32-37.[doi:10.12174/j.issn.2096-9600.2021.06.08]
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消肿止痛巴布剂的制备工艺研究
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
34
期数:
2021年06期
页码:
32-37
栏目:
出版日期:
2021-06-15

文章信息/Info

Title:
Study on the Preparation Process of Xiaozhong Zhitong Cataplasm
作者:
李智勇1,2, 陈玉兴1,2, 赵自明1,2, 张建军1,2, 陈雪婷1,2, 卢泳1,2,3
1.广东省第二中医院/广东省中医药工程技术研究院，广东 广州 510095
2.广东省中医药研究开发重点实验室
3.广州中医药大学
Author(s):
LI Zhiyong1,2, CHEN Yuxing1,2, ZHAO Ziming1,2, ZHANG Jianjun1,2, CHEN Xueting1,2, LU Yong1,2,3
1.Guangdong Second Traditional Chinese Medicine Hospital/Guangdong Research Institute of Traditional Chinese Medicine Manufacturing Techonology, Guangzhou 510095, China
2.Guangdong Provincial Key Laboratory of Traditional Chinese Medicine Research and Development
3.Guangzhou University of Chinese Medicine
关键词:
消肿止痛巴布剂; 提取工艺; 基质配方; 均匀设计
Keywords:
cataplasm; extraction process; matrix formula; uniform design
分类号:
R283
DOI:
10.12174/j.issn.2096-9600.2021.06.08
摘要:
目的确定消肿止痛巴布剂的制备工艺。 方法根据临床应用现状和药材的理化性质，制备不同工艺的样品，以对大鼠急性软组织损伤的作用为评价指标，优选适宜的提取工艺。采用正交试验设计和单因素试验优选提取、浓缩工艺参数，采用均匀试验设计法优选消肿止痛巴布剂的基质配方。 结果优选的制备工艺为：处方量四分之一的饮片粉碎成细粉备用；其余饮片加水提取3次，每次加8倍水，提取1 h，滤过，合并滤液，减压浓缩（80℃，-0.06 MPa）至相对密度为1.25的清膏；按比例称取细粉和清膏，加入高岭土∶甘油∶酒石酸∶甘羟铝∶吐温80∶聚丙烯酸钠（质量比1.20∶50∶0.10∶0.6∶0.15∶8.4）制成的基质，混匀，涂布，切片，即得。 结论确定的消肿止痛巴布剂制备工艺基本合理，产品质量稳定，可以用于该制剂的生产。
Abstract:
ObjectiveTo determine the preparation process of Xiaozhong Zhitong cataplasm. MethodsAccording to the current situation of clinical application and physicochemical properties of medicinal materials, the samples were prepared by different techniques, and the effects on acute soft tissue injury in rats were taken as the evaluation index to optimize the appropriate extraction process. Orthogonal design and single factor test were used to optimize the extraction and concentrate process parameters, uniform design to optimize the matrix formula of Xiaozhong Zhitong cataplasm. ResultsThe optimal preparation process was as follows: crushing a quarter of the prescription decoction pieces into fine powder for standby; extracting the remaining pieces with water for three times, adding eight times of water for each time, after extracting for one hour and filtration, combining and concentrating the filtrates under reduced pressure (80 ℃, -0.06 MPa) to the extract with a relative density of 1.25; weighing the fine powder and the clear paste in proportion, adding the matrix made of kaolin: glycerol: tartaric acid: hydroxyaluminum glycinate: Tween 80:sodium polyacrylate (mass ratio 1.20∶50∶0.10∶0.6∶0.15∶8.4), mixing, coating, slicing. ConclusionThe preparation technology of Xiaozhong Zhitong cataplasm is reasonable and the product quality is stable, which can be used for the production of swelling-reducing pain-relieving cataplasm.

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备注/Memo

备注/Memo:
李智勇（1977—），男，博士学位，主任中药师。研究方向：中药新制剂与药效物质基础研究。广东省科技计划项目（2017A070701017）；广东省中医药科技创新平台建设项目［粤中医函（2017）］340号］。
更新日期/Last Update: 2021-06-15