[1]殷美琦,金丽娟,刘元君,等.吴门调脂颗粒治疗肥胖2型糖尿病合并代谢性脂肪性肝病疗效观察[J].西部中医药,2023,36(04):97-100.[doi:10.12174/j.issn.2096-9600.2023.04.22]
　YIN Meiqi,JIN Lijuan,LIU Yuanjun,et al.Clinical Observation on Wumen Fat-regulating Granules in the Treatment of Obesity Type Two Diabetes Mellitus and Metabolic Associated Fatty Liver Disease[J].Western Journal of Traditional Chinese Medicine,2023,36(04):97-100.[doi:10.12174/j.issn.2096-9600.2023.04.22]
点击复制

吴门调脂颗粒治疗肥胖2型糖尿病合并代谢性脂肪性肝病疗效观察
分享到：

《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
36
期数:
2023年04期
页码:
97-100
栏目:
出版日期:
2023-04-15

文章信息/Info

Title:
Clinical Observation on Wumen Fat-regulating Granules in the Treatment of Obesity Type Two Diabetes Mellitus and Metabolic Associated Fatty Liver Disease
作者:
殷美琦, 金丽娟, 刘元君, 黄菲
南京中医药大学附属苏州市中医医院，江苏 苏州 215009
Author(s):
YIN Meiqi, JIN Lijuan, LIU Yuanjun, HUANG Fei
Suzhou Hospital of Traditional Chinese Medicine Affiliated to Nanjing University of Chinese Medicine, Suzhou 215009, China
关键词:
糖尿病; 2型; 肥胖; 调脂颗粒; 代谢相关脂肪性肝病; 吴门医派
Keywords:
diabetes mellitus;  type two; obesity; fat-regulating granules; metabolic associated fatty liver disease; medical school
分类号:
R587.2
DOI:
10.12174/j.issn.2096-9600.2023.04.22
文献标志码:
B
摘要:
目的观察吴门医派调脂颗粒治疗肥胖2型糖尿病（type 2 diabetes mellitus，T2DM）合并代谢相关脂肪性肝病（metabolic associated fatty liver disease，MAFLD）的临床疗效及对血清趋化素（Chemerin）水平的影响。 方法纳入55例肥胖T2DM合并MAFLD患者，随机分为观察组（28例）和对照组（27例）。对照组采用常规西医治疗，观察组在此基础上加用调脂颗粒治疗。治疗12周后，观察两组体质指数（body mass index，BMI）、空腹血糖（fasting plasma glucose，FPG）、糖化血红蛋白（glucosylated hemoglobin，HbA1c）、胰岛素抵抗指数（homeostasis model assessment-insulin resistance，HOMA-IR）、血脂、肝功能指标及血清Chemerin水平。 结果治疗12周后，观察组BMI、FPG、HbA1c、谷丙转氨酶（alanine aminotransferase，ALT）、谷草转氨酶（aspartate aminotransferase，AST）、血清总胆固醇（total cholesterol，TC）、甘油三酯（triglyceride，TG）、低密度脂蛋白胆固醇（low density lipoprotein cholesterol，LDL-C）均较治疗前显著降低（P＜0.01），血清Chemerin、肿瘤坏死因子α（tumor necrosis factor-α，TNF-α）、白细胞介素8（interleukin-8，IL-8）水平亦较治疗前显著降低（P＜0.01）。对照组BMI、FPG、HbA1c、ALT、AST、TC、TG、IL-8较治疗前下降（P<0.05），血清Chemerin、TNF-α水平较治疗前显著下降（P＜0.01）。治疗后，观察组与对照组相比，BMI、FPG、TC、LDL-C、血清Chemerin、TNF-α、IL-8水平更低（P＜0.05）。 结论吴门调脂颗粒治疗肥胖T2DM合并MAFLD能够减轻体质量、改善糖脂代谢，降低血清Chemerin水平，减轻炎症状态，提高临床疗效。
Abstract:
ObjectiveTo observe clinical efficacy of Wumen fat-regulating granules in treating obesity type two diabetes mellitus (T2DM) and MAFLD, and its influence on the level of Chemerin. Methodsfifty-five patients were included and randomized into the observation group (28 cases)and the control group (27 cases). The control group adopted conventional therapy of Western medicine, and the observation group took fat-regulating granules orally. After 12 weeks of the treatment, to observe BMI, FPG, HbA1c, HOMA-IR, blood lipid, the indexes of liver function and the levels of serum Chemerin between both groups. ResultsAfter 12 weeks of the treatment, BMI, FPG, HbA1c, ALT, AST, TC, TG and LDL-C of the observation group lowered than before the treatment signi-ficantly (P<0.01), the levels of serum Chemerin, TNF-α and IL-8 reduced compared with before the treatment noticeably (P<0.01). BMI, FPG, HbA1c, ALT, AST, TC, TG and IL-8 of the control group lowered than before the treatment (P<0.05), the levels of serum Chemerin and TNF-α lowered remarkably than before the treatment (P<0.01). After the treatment, BMI, FPG, TC, LDL-C, the levels of serum Chemerin, TNF-α and IL-8 were lower when the observation group was compared with the control group (P<0.05). ConclusionWumen fat-regulating granules of in the treatment of obesity T2DM and MAFLD could lose weight, improve glucose and lipid metabolism, reduce the levels of serum Chemerin, relieve inflammatory state and raise clinical effects.

相似文献/References:

[1]贾晓杰,刘志跃△.红花制剂在糖尿病及其并发症中的研究进展[J].西部中医药,2013,26(03):127.
　JIA Xiaojie,LIU Zhiyue.Research Progress of Safflower Preparation in Diabetes Mellitus and the Complication[J].Western Journal of Traditional Chinese Medicine,2013,26(04):127.
[2]范宗慧.温肾健脾法治疗糖尿病心得[J].西部中医药,2012,25(09):43.
　FAN Zong-hui.Experience on Method of WenShen JianPi in Treating Diabetes[J].Western Journal of Traditional Chinese Medicine,2012,25(04):43.
[3]张国民.消渴清颗粒治疗糖尿病周围神经病变疗效分析[J].西部中医药,2012,25(08):66.
　ZHANG Guo-min.XiaoKeQing Granules in Treating Diabetic Peripheral Neuropathy[J].Western Journal of Traditional Chinese Medicine,2012,25(04):66.
[4]张载宏.丹红注射液联合多贝斯治疗糖尿病周围神经病变临床疗效观察[J].西部中医药,2013,26(07):74.
　ZHANG Zaihong.Clinical Observation on DanHong Injection and Calcium Dobesilate Capsules in Treating Diabetic Peripheral Neuropathy[J].Western Journal of Traditional Chinese Medicine,2013,26(04):74.
[5]段丽萍.中西医结合治疗糖尿病周围神经病变30例[J].西部中医药,2013,26(07):90.
　DUAN Liping.Integrative Medicine in Treating 30 Cases of Diabetic Peripheral Neuropathy[J].Western Journal of Traditional Chinese Medicine,2013,26(04):90.
[6]龚云,王超,亢建国.运动结合灵芝多糖干预对糖尿病大鼠血脂的影响[J].西部中医药,2013,26(08):8.
　GONG Yun,WANG Chao,KANG Jianguo.Effects of Exercise and Ganoderan Intervention on Blood Fat of Rats with Diabetes Mellitus[J].Western Journal of Traditional Chinese Medicine,2013,26(04):8.
[7]呼宝娟.护理干预对肺结核合并糖尿病患者生活质量的影响[J].西部中医药,2013,26(09):125.
　HU Baojuan.Effects of Nursing Intervention on Life Quality of Diabetic Patients Complicated with Pulmonary Tuberculosis[J].Western Journal of Traditional Chinese Medicine,2013,26(04):125.
[8]张艳玲,高文菊.系统性干预对糖尿病并发症发生发展的影响[J].西部中医药,2013,26(12):81.
　ZHANG Yanling,GAO Wenju.Effects of Systematic Intervention on the Onset and Progression of Diabetic Complications[J].Western Journal of Traditional Chinese Medicine,2013,26(04):81.
[9]童玲利.外伤性跟骨骨折合并糖尿病患者围手术期护理体会[J].西部中医药,2014,27(02):131.
　TONG Lingli.Perioperative Care for the Patients with Diabetes Mellitus and Traumatic Calcaneal Fracture[J].Western Journal of Traditional Chinese Medicine,2014,27(04):131.
[10]陈海燕,刘怀珍.糖尿病周围神经病变的中医研究[J].西部中医药,2014,27(03):138.
　CHEN Haiyan,LIU Huaizhen.TCM Study of Diabetic Peripheral Neuropathy[J].Western Journal of Traditional Chinese Medicine,2014,27(04):138.
[11]段尚勤.糖脂消合罗格列酮治疗2型糖尿病合并非酒精性脂肪肝疗效观察[J].西部中医药,2013,26(02):88.
　DUAN Shangqin.Clinical Observation on TangZhiXiao and Rosiglitazone Maleate in Treating Type 2 Diabetes Mellitus Complicated with Non Alcoholic Fatty Liver Disease[J].Western Journal of Traditional Chinese Medicine,2013,26(04):88.
[12]张军和,杨振亚,张永琴.安糖1号治疗初发2型糖尿病并代谢综合征40例临床观察[J].西部中医药,2013,26(05):1.
　ZHANGJunhe,YANGZhenya,ZHANGYongqin.ClinicalObservationonAnTangNo.1intheTreatmentfor40CasesofDiabetesMellitusTypeTwoatPrimaryStageComplicatedwithMetabolismSyndrome[J].Western Journal of Traditional Chinese Medicine,2013,26(04):1.
[13]吕志芹,魏文慧.胰岛素联合痰热清治疗2型糖尿病合并肺部感染49例[J].西部中医药,2013,26(06):85.
　LV Zhiqin,WEI Wenhui.Insulin and TanReQing Injection in Treating 49 Cases of Diabetes Mellitus Type Two Complicated with Pulmonary Infection[J].Western Journal of Traditional Chinese Medicine,2013,26(04):85.
[14]刘希宏.中西药物联用对老年高血压合并2型糖尿病患者肾功能的保护作用[J].西部中医药,2012,25(07):9.
　LIU Xi-hong.Protection of Integrated Traditional Chinese and Western Medicine on Renal Function of Patients with Senile Hypertension and Type 2 Diabetes Mellitus[J].Western Journal of Traditional Chinese Medicine,2012,25(04):9.
[15]梁伟.护理干预在2型糖尿病患者护理中的应用[J].西部中医药,2013,26(12):128.
　LIANG Wei.Application of Nursing Intervention to the Patients with Diabetes Mellitus Type 2[J].Western Journal of Traditional Chinese Medicine,2013,26(04):128.
[16]王璟.中药对胰岛素治疗2型糖尿病低血糖发生率的影响[J].西部中医药,2014,27(04):94.
　WANG Jing.Effects of Herbs on the Incidence Rate of Hypoglycemia of the Patients with Type Two Diabetes Mellitus[J].Western Journal of Traditional Chinese Medicine,2014,27(04):94.
[17]齐丽丽,侯敏,尚新秀,等.2 型糖尿病患者八段锦锻炼态度的调查*[J].西部中医药,2014,27(08):36.
[18]张智明,陈孝民△.芪蛭消渴方联合西药基础治疗对 2 型糖尿病症状及血脂的影响*[J].西部中医药,2014,27(08):79.
[19]马红,王海红Δ,蒲小庆,等.中西医结合治疗 2 型糖尿病 68 例[J].西部中医药,2014,27(08):95.
[20]夏海萍,黄琴清,李志英,等.循证护理应用于2型糖尿病合并高血压病患者中的效果观察[J].西部中医药,2014,27(10):140.

备注/Memo

备注/Memo:
殷美琦（1988—），女，副主任医师。研究方向：内分泌代谢病的中医药防治。苏州市卫健委科教兴卫项目（KJXW2017044）；苏州市科技局项目（SYSD2019148）；苏州市中西医结合学会项目（SYSD2019214）；苏州市临床医学专家团队引进项目（SZYJTD201718）。
更新日期/Last Update: 2023-04-15