[1]史敏,张露蓉,江国荣,等.中药干预糖尿病胃轻瘫胃肠动力信号通路的研究进展[J].西部中医药,2023,36(06):153-157.[doi:10.12174/j.issn.2096-9600.2023.06.37]
　SHI Min,ZHANG Lurong,JIANG Guorong,et al.Research Progress of TCM Intervention in Gastrointestinal Motility Signal Pathway of Diabetic Gastroparesis[J].Western Journal of Traditional Chinese Medicine,2023,36(06):153-157.[doi:10.12174/j.issn.2096-9600.2023.06.37]
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中药干预糖尿病胃轻瘫胃肠动力信号通路的研究进展
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
36
期数:
2023年06期
页码:
153-157
栏目:
出版日期:
2023-06-15

文章信息/Info

Title:
Research Progress of TCM Intervention in Gastrointestinal Motility Signal Pathway of Diabetic Gastroparesis
作者:
史敏1,2, 张露蓉1,2, 江国荣1,2, 王斐1,2
1.南京中医药大学附属苏州市中医医院中心实验室，江苏 苏州 215009
2.苏州市吴门医派研究院，江苏 苏州 215009
Author(s):
SHI Min1,2, ZHANG Lurong1,2, JIANG Guorong1,2, WANG Fei1,2
1.Central Lab, Suzhou Hospital of Traditional Chinese Medicine, Suzhou 215009, China
2.Suzhou Academy of Wumen Medical School, Suzhou 215009, China
关键词:
糖尿病胃轻瘫; 胃肠动力; 信号通路; 中药
Keywords:
diabetic gastroparesis; gastrointestinal motility; signal pathway; TCM
分类号:
R587.2
DOI:
10.12174/j.issn.2096-9600.2023.06.37
文献标志码:
A
摘要:
结合近五年糖尿病胃轻瘫的基础实验研究，对中药干预糖尿病胃轻瘫的的胃肠动力信号通路研究进行综述。发现干细胞因子/酪氨酸激酶信号通路、Ras同源A蛋白/RhoA相关蛋白激酶RhoA/ROCK等多条信号通路参与了糖尿病胃轻瘫的发生和发展过程；中药治疗糖尿病胃轻瘫疗效确切，具有多角度多靶点优势，但缺乏物质基础研究，需要开展符合辨证论治和遣方用药规律的物质基础和作用机理研究，以期为临床有效治疗糖尿病胃轻瘫提供思路。
Abstract:
By reviewing basic experimental studies of diabetic gastroparesis (DG) in the recent five years, the paper summarizes TCM intervention in gastrointestinal motility signal pathway of DG. Multiple signal pathways including stem cell factor/tyrosine kinase signaling pathway, Ras homologous A protein/RhoA-associated protein kinase RhoA/ROCK, have participated in the occurrence and development of DG. TCM could gain definite effects in the treatment of DG, possessing the advantages of many angles and targets, however, lacking material basic research, therefore, the studies on material foundation and the mechanism conforming to the laws of syndrome differentiation and treatment, medication and dispatching prescription, need to be launched, in order to provide the ideas for clinical and effective treatment of DG.

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备注/Memo

备注/Memo:
史敏（1987—），女，硕士学位，主管药师。研究方向：糖尿病及其并发症的防治。；王斐（1979—），女，硕士学位，高级工程师。研究方向：中药防治糖尿病胃轻瘫的机制研究。国家自然科学基金青年基金（81903899）。
更新日期/Last Update: 2023-06-15