[1]牛喜信,刘涛,李金鹏.健骨益痹方联合PKP治疗老年骨质疏松性胸腰椎压缩骨折的临床观察[J].西部中医药,2023,36(08):86-89.[doi:10.12174/j.issn.2096-9600.2023.08.21]
　NIU Xixin,LIU Tao,LI Jinpeng.Clinical Observation on Jiangu Yibi Formulation Combined with PKP in the Treatment of Osteoporotic Thoracolumbar Compression Fractures[J].Western Journal of Traditional Chinese Medicine,2023,36(08):86-89.[doi:10.12174/j.issn.2096-9600.2023.08.21]
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健骨益痹方联合PKP治疗老年骨质疏松性胸腰椎压缩骨折的临床观察
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
36
期数:
2023年08期
页码:
86-89
栏目:
出版日期:
2023-08-15

文章信息/Info

Title:
Clinical Observation on Jiangu Yibi Formulation Combined with PKP in the Treatment of Osteoporotic Thoracolumbar Compression Fractures
作者:
牛喜信, 刘涛, 李金鹏
甘肃省中医院，甘肃 兰州 730050
Author(s):
NIU Xixin, LIU Tao, LI Jinpeng
Gansu Provincial Hospital of Traditional Chinese Medicine,Lanzhou 730050, China
关键词:
压缩骨折; 骨质疏松性; 胸椎; 腰椎; 健骨益痹方; 经皮椎体后凸成形术; 骨密度; 疼痛
Keywords:
compression fractures;  osteoporotic; thoracic vertebrae; lumbar vertebrae; formulation; PKP; bone density; pain
分类号:
R683.1
DOI:
10.12174/j.issn.2096-9600.2023.08.21
文献标志码:
B
摘要:
目的观察健骨益痹方联合经皮椎体后凸成形术（percutaneous kyphoplasty，PKP）治疗老年骨质疏松性胸腰椎压缩性骨折的临床疗效。 方法将60例老年骨质疏松性胸腰椎压缩性骨折患者，随机分为观察组和对照组，每组30例。观察组采用健骨益痹方联合PKP治疗，对照组采用阿伦磷酸钠片联合PKP治疗。观察比较两组治疗前后Cobb角、骨折椎体前缘高度（anterior vertebral height，AVH）、疼痛视觉模拟评分（visual analog scale，VAS）、Oswestry功能障碍指数（oswestry disability index，ODI）、腰椎骨密度（bone mineral density，BMD）、血清碱性磷酸酶（alkaline phosphatase，ALP）、骨钙素（osteocalcin，BGP）、I型胶原交联C末端肽（type I collagen cross-linked C-terminal peptide，CTXI）、血清抗酒石酸酸性磷酸酶（tartrate resistant acid phosphatase-5b，TRACP-5b）。 结果两组患者治疗后、及6月Cobb角、AVH高度、VAS、ODI、腰椎BMD、ALP、BGP、CTXI、TRAP-5b与治疗前相比较，差异有统计学意义（P＜0.05），观察组改善程度显著优于对照组（P＜0.05）。 结论健骨益痹方联合PKP能够改善骨代谢、增加骨密度，恢复伤椎高度，维持脊柱稳定。
Abstract:
ObjectiveTo observe clinical effects of Jiangu Yibi formulation and PKP in the treatment of osteoporotic thoracolumbar compression fractures. MethodsSixty patients were randomized into the observation group and the control group, with 30 cases in each group. The observation group were treated with Jiangu Yibi formulation and PKP, and the control group with alendronate sodium tablets and PKP. To observe and compare Cobb angles, AVH, VAS, ODI, BMD, ALP, BGP, CTX1 and TRACP-5b before and after the treatment between both groups. ResultsThe difference had statistical meaning in Cobb angles, AVH, VAS, ODI, lumbar BMD, ALP, BGP, CTX1, TRAP-5b after the treatment and six months after the treatment between both groups (P<0.05), the improve-ments of the observation group were remarkably superior to these of the control group (P<0.05). ConclusionJiangu Yibi formulation joined with PKP could improve bone metabolism, increase bone density, restore the height of the injured vertebrae and maintain the spinal stability.

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备注/Memo

备注/Memo:
牛喜信（1975—），男，副主任医师。研究方向： 骨质疏松疾病的中医药防治及研究。甘肃省中医药管理局科研课题（GZK-2019-2）。
更新日期/Last Update: 2023-08-15