[1]何晓辰,彭光远,王金榜.寒痉汤加减治疗绝经后骨质疏松症寒凝证临床研究[J].西部中医药,2023,36(09):1-5.[doi:10.12174/j.issn.2096-9600.2023.09.01]
　HE Xiaochen,PENG Guangyuan,WANG Jinbang.Clinical Study on Modified Hanjing Tang in the Treatment of Postmenopausal Osteoporosis of Coagulated Cold Pattern[J].Western Journal of Traditional Chinese Medicine,2023,36(09):1-5.[doi:10.12174/j.issn.2096-9600.2023.09.01]
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寒痉汤加减治疗绝经后骨质疏松症寒凝证临床研究
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
36
期数:
2023年09期
页码:
1-5
栏目:
出版日期:
2023-09-15

文章信息/Info

Title:
Clinical Study on Modified Hanjing Tang in the Treatment of Postmenopausal Osteoporosis of Coagulated Cold Pattern
作者:
何晓辰, 彭光远, 王金榜
河北中医学院第一附属医院，河北 石家庄 050011
Author(s):
HE Xiaochen, PENG Guangyuan, WANG Jinbang
The First Affiliated Hospital of Hebei University of Chinese Medicine, Shijiazhuang 050011, China
关键词:
绝经后骨质疏松症; 寒凝证; 寒痉汤; 李士懋; 临床研究
Keywords:
postmenopausal osteoporosis; coagulated cold pattern; clinical study
分类号:
R274.9
DOI:
10.12174/j.issn.2096-9600.2023.09.01
文献标志码:
A
摘要:
目的观察寒痉汤加减治疗绝经后骨质疏松症（postmenopausal osteoporosis,PMOP）寒凝证的临床疗效。 方法将60例PMOP寒凝证患者随机分为对照组和治疗组各30例。对照组予常规西医治疗；治疗组在对照组基础上予寒痉汤加减治疗，观察两组患者治疗前后及治疗后6个月中医证候积分、视觉模拟评分量表（visual analogue scale，VAS）评分、血清骨代谢指标、骨密度(bone mineral density，BMD)，并记录药物不良反应。 结果治疗后和治疗后6个月，两组患者中医证候积分、VAS评分较治疗前下降（P＜0.05），治疗组低于对照组（P＜0.05）。治疗后6个月，两组患者血清Ⅰ型胶原氨基端延长肽、β-胶原特殊序列较治疗前下降（P＜0.05）；两组患者BMD较治疗前稍增加，但差异无统计学意义（P＞0.05）。治疗组总有效率为93.3%（28/30），高于对照组的73.3%（22/30）（P＜0.05）。两组患者均未出现明显不良反应。 结论常规西医治疗联合寒痉汤加减能改善绝经后骨质疏松症寒凝证患者临床症状与骨代谢，疗效优于单纯常规西医治疗。
Abstract:
ObjectiveTo observe clinical efficacy of modified Hanjing Tang in the treatment of postmenopausal osteoporosis (PMOP) of coagulated cold pattern. MethodsSixty patients were randomized into the control group and the treatment group, with 30 cases in each group. The control group accepted conventional Western medicine therapy, and the treatment group was given modified Hanjing Tang based on conventional Western medicine therapy, to observe TCM syndrome integrals, VAS, serum bone metabolism indexes, BMD before and after the treatment, six months after the treatment, to record the adverse reaction of drugs. ResultsAfter the treatment and six months after the treatment, TCM syndrome integrals and VAS of both groups reduced than before the treatment (P<0.05), the treatment group was lower than the control group (P<0.05). Six months after the treatment, the amino-terminal lengthening peptide of serum type I collagen and β-collagen special sequence of both groups decreased than before the treatment (P<0.05); BMD of both groups increased slightly than before the treatment, while the difference had no statistical meaning (P>0.05). Total effective rate of the treatment group was 93.3%(28/30), higher than 73.3%(22/30) of the control group (P<0.05). No obvious adverse reaction occurred in both groups. ConclusionConventional Western medicine therapy combined with modified Hanjing Tang could improve clinical symptoms and bone metabolism in PMOP patients, and its clinical effects superior to these of single conventional Western medicine therapy.

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备注/Memo

备注/Memo:
何晓辰（1996—），男，硕士学位。研究方向：骨病与关节损伤的诊治。国家十二五科技支撑计划“名老中医特色治则治法传承项目”（2013BAI13B02）。
更新日期/Last Update: 2023-09-15