[1]王红娟,吕小旭,邹家栋,等.不同品种大黄降尿酸、抗炎和泻下作用比较研究[J].西部中医药,2024,37(01):13-16.[doi:10.12174/j.issn.2096-9600.2024.01.04]
　WANG Hongjuan,LYU Xiaoxu,ZOU Jiadong,et al.Comparative Studies on Uric acid-lowering, Anti-inflammatory, and Purgative Effects of Different Varieties of Dahuang[J].Western Journal of Traditional Chinese Medicine,2024,37(01):13-16.[doi:10.12174/j.issn.2096-9600.2024.01.04]
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不同品种大黄降尿酸、抗炎和泻下作用比较研究

《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
37
期数:
2024年01期
页码:
13-16
栏目:
基础研究
出版日期:
2024-01-15

文章信息/Info

Title:
Comparative Studies on Uric acid-lowering, Anti-inflammatory, and Purgative Effects of Different Varieties of Dahuang
作者:
王红娟1, 吕小旭1, 邹家栋2, 王芳1, 张旭东3
1.甘肃医学院，甘肃 平凉 744000
2.平凉市妇幼保健院，甘肃 平凉 744000
3.平凉旭阳科技有限责任公司，甘肃 平凉 744000
Author(s):
WANG Hongjuan1, LYU Xiaoxu1, ZOU Jiadong2, WANG Fang1, ZHANG Xudong3
1.Gansu Medical College, Pingliang 744000, China
2.Pingliang City Maternal and Child Health Care Hospital, Pingliang 744000, China
3.Pingliang Xuyang Technology Co., LTD, Pingliang 744000, China
关键词:
尿酸; 抗炎; 泻下; 大黄; 总蛋白; Na-K-ATP酶
Keywords:
uric acid; anti-inflammatory effects; purge; total protein; Na-K-ATP enzyme
分类号:
R285.5
DOI:
10.12174/j.issn.2096-9600.2024.01.04
文献标志码:
A
摘要:
目的研究不同品种大黄降尿酸、抗炎和泻下的作用。 方法选取体质量相近的Wistar大鼠90只，通过次黄嘌呤及氧嗪酸钾建立急性高尿酸血症模型，应用角叉菜胶建立足肿胀模型和复方地芬诺酯建立便秘模型，给予药用、掌叶及唐古特大黄高（5 g/kg）、低剂量（1.25 g/kg）水提物，实验另设空白组、阴性对照组和阳性对照组。通过检测给药前后大鼠血液中尿酸值考察降尿酸作用，通过大鼠足肿胀度和足组织液总蛋白含量考察抗炎作用，通过6 h内首次黑便时间、总黑便次数和大鼠结肠内Na+-K+-ATP酶活力含量考察泻下作用。 结果大黄具有降尿酸作用，其效果依次为掌叶大黄、药用大黄和唐古特大黄，3种大黄之间存在差异（P＜0.05）；大黄有一定的抗炎作用，其效果依次为唐古特大黄、掌叶大黄和药用大黄，3种大黄之间存在差异（P＜0.05）；大黄具有泻下作用，其效果依次为唐古特大黄、掌叶大黄和药用大黄，3种大黄之间存在差异（P＜0.05）。 结论大黄水提取物有较强的降尿酸、抗炎和泻下作用，不同品种之间药理作用存在一定差别，临床应区别用药。
Abstract:
To compare uric acid(UA)-lowering, anti-inflammatory, and purgative effects of different varieties of Dahuang (rhubarb, Rhei Radix et Rhizoma). MethodsAll 90 Wistar rats of similar body mass were selected, and prepared into the models with acute hyperuricaemia via hypoxanthine and potassium oxonate, foot swelling models were established through the application of carrageenan gum, constipation models were built up via compound diphenoxylate, and they were given aqueous extract of rhubarb for medicinal use (Rheum officinale Baill.), Zhangye rhubarb (Rheum palmatum L.) and Tangut rhubarb (Rheum tanguticum Maxim. ex Balf.) in high dose (5 g/kg) and low dose (1.25 g/kg), a blank group, negative control group and positive control group were also set up in the experiment. To survey uric acid-lowering effects by detecting UA in the blood of rats, to explore anti-inflammatory effects by observing rat foot swelling and measuring the contents of total protein in foot tissue fluid, and to investigate the purgative effects by observing the time of first dark stool within six hours, total number of dark stool, and the contents and activity of colon Na+-K+-ATP enzyme. ResultsRhubarb could significantly lower the levels of UA, ranking in the order of effects: Zhangye rhubarb, rhubarb for medicinal use and Tangut rhubarb, and there was a significant difference (P<0.05); rhubarb owns certain anti-inflammatory effects, ranking in the order of effects: Tangut rhubarb, Zhangye rhubarb and rhubarb for medicinal use, the differences existed between three kinds of rhubarb (P<0.05); rhubarb possesses purgative effects, and it ranked in the sequences: Tangut rhubarb, Zhangye rhubarb and rhubarb for medicinal use, noticeable differences existed between three kinds of rhubarb (P<0.05). ConclusionAqueous extract of rhubarb has stronger effects of lowering UA, resisting inflammation and purgative effects, certain differences exist in pharmaceutical effects between different varieties of rhubarbs, and it should be differentiated in clinical practice.

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备注/Memo

备注/Memo:
王红娟（1984—），女，硕士学位，讲师。研究方向：中药化学和中药质量控制。E-mail：181922169@qq.com。2019年甘肃省高等学校创新能力提升项目（2019B-200）。
更新日期/Last Update: 2024-01-15