[1]焦英霞,刘医农,谢春平.涤痰汤加减联合电针治疗难治性精神分裂症疗效观察[J].西部中医药,2024,37(09):115-119.[doi:10.12174/j.issn.2096-9600.2024.09.25]
　JIAO Yingxia,LIU Yinong,XIE Chunping.Clinical Observation on Modified Ditan Tang Combined with Electroacupuncture in the Treatment of Refractory Schizophrenia[J].Western Journal of Traditional Chinese Medicine,2024,37(09):115-119.[doi:10.12174/j.issn.2096-9600.2024.09.25]
点击复制

涤痰汤加减联合电针治疗难治性精神分裂症疗效观察
分享到：

《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
37
期数:
2024年09期
页码:
115-119
栏目:
临床研究
出版日期:
2024-09-15

文章信息/Info

Title:
Clinical Observation on Modified Ditan Tang Combined with Electroacupuncture in the Treatment of Refractory Schizophrenia
作者:
焦英霞, 刘医农, 谢春平
衡水市第七人民医院精神科，河北 衡水 053000
Author(s):
JIAO Yingxia, LIU Yinong, XIE Chunping
Psychiatry, Hengshui Seventh People's Hospital, Hengshui 053000, China
关键词:
精神分裂症; 难治性; 精神症状; 不良反应; 涤痰汤; 电针
Keywords:
schizophrenia;  refractory; psychiatric symptoms; adverse reaction; electroacupuncture
分类号:
R749.3
DOI:
10.12174/j.issn.2096-9600.2024.09.25
文献标志码:
B
摘要:
目的观察涤痰汤加减联合电针治疗难治性精神分裂症的临床疗效、精神症状与安全性。 方法将难治性精神分裂症患者150例按随机数字表法分为对照组和试验组各75例。对照组予氯氮平治疗，试验组在对照组基础上予涤痰汤加减联合电针治疗，两组均治疗8周。比较两组患者临床疗效及治疗前后精神症状、社会功能、记忆、认知功能、事件相关电位P300、血清指标水平与不良反应发生情况。 结果治疗8周后试验组总有效率为93.33%（70/75），高于对照组的78.67%（59/75）（P＜0.05）；治疗8周后两组患者阳性和阴性症状量表评分、精神分裂症认知功能评定量表评分、事件相关电位P300潜伏期均降低（P＜0.05），试验组降低更明显（P＜0.05）；治疗8周后两组患者社会功能量表评分、韦氏成人记忆量表评分、简易精神状态量表评分、事件相关电位P300波幅、血清褪黑素、5-羟色胺、脑源性神经营养因子均升高（P＜0.05），试验组升高更明显（P＜0.05）。试验组不良反应发生率为5.33%（4/75），低于对照组的16.00%（12/75）（P＜0.034）。 结论涤痰汤加减联合电针可提高难治性精神分裂症患者临床疗效，改善患者精神症状、社会功能、记忆、认知功能，且具有较好的安全性。
Abstract:
ObjectiveTo observe clinical effects，mental symptoms and the safety of modified Ditan Tang (Phlegm-removing decoction) and electroacupuncture in treating refractory schizophrenia. MethodsAll 150 patients were allocated to the control group and the experiment group using random number table method with 75 cases in each. The control group was treated with clozapine, and the experiment group was treated with modified Ditan Tang and electroacupuncture based on the control group, both groups were treated for eight weeks. To compare clinical effects of the two groups, psychiatric symptoms, social function, memory and cognitive function, event-related potential P300, the levels of serum indexes and the incidence of adverse reactions before and after the treatment. ResultsAfter eight weeks of the treatment, total effective rate of the experiment group was 93.33% (70/75), higher than 78.67% (59/75) of the control group (P<0.05). After eight weeks of the treatment, the scores of the positive and negative syndrome scale (PANSS), schizophrenia cognition rating scale (SCoRS) and event-related potential P300 latency reduced in the two groups (P<0.05), the decrease of the experiment group was more evident (P<0.05). After eight weeks of the treatment, the scores of social functioning scale (SFS), Wechsler Memory Scale (WMS) and the Mini-Mental State Examination (MMSE), event-related potential P300 latency, the levels of serum melatonin, 5-hydroxytryptamine (5-HT) and brain-derived neurotrophic factor (BDNF) raised in the two groups (P<0.05), the increase of the experiment group was more obvious (P<0.05). The incidence of adverse reaction of the experiment group was 5.33% (4/75), lower than 16.00% (12/75) of the control group (P<0.034). ConclusionModified Ditan Tang and electroacupuncture in treating refractory schizophrenia could enhance clinical effects, improve the patients′ psychiatric symptoms, social function, memory and cognitive function with better safety.

相似文献/References:

[1]石洲宝,陈长浩,高娜,等.安神二号胶囊对慢性精神分裂症患者认知和社会功能的影响[J].西部中医药,2015,28(04):1.
[2]张淑萍,阮学平,段红梅,等.中医药治疗精神分裂症的文献引文分析[J].西部中医药,2015,28(05):69.
[3]王润泽,任俊赏.涤痰汤联合哌罗匹隆治疗首发精神分裂症30例[J].西部中医药,2017,30(02):89.
　WANG Runze,REN Junshang.DiTan Tang Combined with Perospirone in Treating 30 Cases of First Episode Schizophrenia[J].Western Journal of Traditional Chinese Medicine,2017,30(09):89.
[4]汪永国.参芪地黄汤对难治性肾病综合征患者肾功能的影响[J].西部中医药,2016,29(05):76.
　WANG Yongguo.The Effects of ShenQi DiHuang Tang on Renal Function of the Patients with Refractory Nephrotic Syndrome[J].Western Journal of Traditional Chinese Medicine,2016,29(09):76.
[5]石洲宝,刘海涛△,刘成松,等.安神胶囊治疗精神分裂症患者睡眠障碍临床研究[J].西部中医药,2017,30(03):5.
　SHI Zhoubao,LIU Haitao,LIU Chengsong,et al.Clinicof the Patients Suffering from Schizophreniaal Study of AnShen Capsules in Treating Sleep Disorders[J].Western Journal of Traditional Chinese Medicine,2017,30(09):5.
[6]张永国,郭晓娟△.中药汤剂联合阿立哌唑治疗慢性精神分裂症59例[J].西部中医药,2017,30(12):88.
　ZHANG Yonguo,GUO Xiaojuan.Herbal Decoction Combined with Aripiprazole in Treating 59 Cases of Chronic Schizophrenia[J].Western Journal of Traditional Chinese Medicine,2017,30(09):88.
[7]单建华,孙 菡,罗 新.引导式教育训练对长期住院精神分裂症患者的影响[J].西部中医药,2018,31(08):120.
　SHAN Jianhua,SUN Han,LUO Xin.Effects of Directed Training on Long-stay Schizophrenics[J].Western Journal of Traditional Chinese Medicine,2018,31(09):120.
[8]曾奕彬,胡号应,葛鑫宇.涤痰化瘀理神汤治疗精神分裂症的效果及对患者体质的影响[J].西部中医药,2020,33(07):86.[doi:10.12174/j.issn.1004-6852.2020.07.22]
　ZENG Yibin,HU Haoying,GE Xinyu.Clinical Effects of Ditan Huayu Lishen Tang in Treating Schizophrenia and Its Influence on the Constitutions of the Patients[J].Western Journal of Traditional Chinese Medicine,2020,33(09):86.[doi:10.12174/j.issn.1004-6852.2020.07.22]
[9]杨兰,冯玉霞,宁静,等.经颅磁刺激联合康复训练对慢性精神分裂症患者阴性症状的影响[J].西部中医药,2022,35(07):106.[doi:10.12174/j.issn.2096-9600.2022.07.28]
　YANG Lan,FENG Yuxia,NING Jing,et al.Effects of Transcranial Magnetic Stimulation Combined with Rehabilitation Training on Negative Symptoms in Patients with Chronic Schizophrenia[J].Western Journal of Traditional Chinese Medicine,2022,35(09):106.[doi:10.12174/j.issn.2096-9600.2022.07.28]
[10]何琼,高晓东,李晓琴,等.结核丸联合抗结核药物治疗反复难治性结核病的临床疗效观察[J].西部中医药,2021,34(06):110.[doi:10.12174/j.issn.2096-9600.2021.06.27]
　HE Qiong,GAO Xiaodong,LI Xiaoqin,et al.Observation on Clinical Effects of Tuberculosis Pills Combined with Antituberculosis Drugs in the Treatment of Recurrent Refractory Tuberculosis[J].Western Journal of Traditional Chinese Medicine,2021,34(09):110.[doi:10.12174/j.issn.2096-9600.2021.06.27]

备注/Memo

备注/Memo:
焦英霞（1984—），女，主治医师。研究方向：精神科相关疾病的诊疗。E-mail：jyx18831842302@163.com。河北省中医药管理局科研计划项目（2023465）。
更新日期/Last Update: 2024-09-15