[1]石洲宝,陈长浩,高娜,等.安神二号胶囊对慢性精神分裂症患者认知和社会功能的影响[J].西部中医药,2015,28(04):1-3.
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安神二号胶囊对慢性精神分裂症患者认知和社会功能的影响
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
28
期数:
2015年04期
页码:
1-3
栏目:
论著·临床论著
出版日期:
2015-04-15

文章信息/Info

文章编号:
1004-6852(2015)04-0001-03
作者:
石洲宝陈长浩高娜刘成松刘敏科黄生辉
甘肃中医学院附属医院,甘肃 兰州 730020
关键词:
精神分裂症慢性安神胶囊维思通认知社会功能
分类号:
R749.3
文献标志码:
A
摘要:
目的:探讨安神胶囊对慢性精神分裂症患者认知和社会功能的影响。方法:采用随机、双盲、双模拟试验方法,将200例患者随机分为观察组和对照组各100例,观察组口服安神胶囊,4粒/次,3次/d;对照组口服维思通,1~1.5 mg/d,2组均治疗8周。于基线和治疗8周末分别计算认知功能评定量表(WCST)评分、社会功能量表(SDSS)评分;于治疗前,治疗第2、4、6、8周分别计算阳性症状量表(SAPS)评分、阴性症状量表(SANS)评分、临床总体印象量表(CGI)评分,并以药物副反应量表(TESS)评定药物的副反应。结果:治疗第8周末,2组SAPS、SANS及SDSS评分均较基线降低,WCST指标中除了观察组持续应答数外均获改善,差异均有统计学意义(P<0.05);观察组SANS、SAPS评分的降低较对照组更为明显(P<0.05)。安神胶囊组WCST各指标改善较对照组明显(P<0.05)。SANA有效率、CGI临床进步率观察组分别为79.9%、86.6%,对照组分别为85.3%、89.3%,2组比较差异均无统计学意义(P>0.05)。结论:安神胶囊对慢性精神分裂症患者认知和社会功能的改善更为有效,且副反应小。

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备注/Memo

备注/Memo:
*基金项目:甘肃省中医药科研项目(编号GZK-2013-33)。作者简介:石洲宝(1965—),男,硕士研究生导师,副主任医师。研究方向:精神(心理)障碍的临床诊治。
更新日期/Last Update: 2015-04-15