[1]姚婷婷,邢雪,王琼,等.中药注射液辅助治疗舒张性心力衰竭临床疗效Meta分析[J].西部中医药,2025,38(10):48-54.[doi:10.12174/j.issn.2096-9600.2025.10.10]
　YAO Tingting,XING Xue,WANG Qiong,et al.Efficacy of Traditional Chinese Medicine Injection in the Treatment of Diastolic Heart Failure: A Meta-Analysis[J].Western Journal of Traditional Chinese Medicine,2025,38(10):48-54.[doi:10.12174/j.issn.2096-9600.2025.10.10]
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中药注射液辅助治疗舒张性心力衰竭临床疗效Meta分析()

《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
38
期数:
2025年10期
页码:
48-54
栏目:
二次研究
出版日期:
2025-10-15

文章信息/Info

Title:
Efficacy of Traditional Chinese Medicine Injection in the Treatment of Diastolic Heart Failure: A Meta-Analysis
作者:
姚婷婷, 邢雪, 王琼, 门丹阳, 康启, 白宝宝
陕西中医药大学第二附属医院，陕西 咸阳 712000
Author(s):
YAO Tingting, XING Xue, WANG Qiong, MEN Danyang, KANG Qi, BAI Baobao
The Second Affiliated Hospital of Shanxi University of Traditional Chinese Medicine,Xianyang 712000Clinical Effects of Herbal Injections as Adjuvant Therapy in the Treatment of Diastolic Heart Failure: A Meta-analysisYAO Tingting, XING Xue△, WANG Qiong, M
关键词:
舒张性心力衰竭; 中药注射液; 随机对照试验; Meta分析
Keywords:
diastolic heart failure; herbal injection; randomized controlled trials; Meta analysis
分类号:
R256.2
DOI:
10.12174/j.issn.2096-9600.2025.10.10
文献标志码:
A
摘要:
目的评价常规西医治疗联合中药注射液治疗舒张性心力衰竭（diastolic heart failure，DHF）的临床疗效。 方法检索中国知网、维普、万方、CBM、PubMed、Embase、Cochrane Library等数据库，筛选符合条件的随机对照试验研究，检索时间为2011年1月至2021年6月。使用Cochrance质量评价表评价文献质量，运用RevMan 5.4软件进行Meta分析。 结果纳入16篇文献，共1620例患者，其中治疗组819例，对照组801例。Meta分析结果显示：与单纯西医常规治疗相比，联合中药注射液治疗能显著改善患者心功能（RR=1.24，95%CI：1.17～1.30，P＜0.000 01）；降低患者B型钠尿肽（MD=-94.58，95%CI：-132.61～-56.54，P＜0.000 01）和N端脑钠肽前体（MD=-199.77，95%CI：-290.71～-108.82，P＜0.000 01）水平；增加6 min步行距离（MD=62.25，95%CI：45.45～79.04，P＜0.000 01）；提高左心室射血分数（MD=2.73，95%CI：1.53～3.92，P＜0.000 01）；改善心室舒张功能［包括舒张早期与晚期二尖瓣最大血流速度比值（MD=0.31，95%CI：0.21～0.42，P＜0.000 01）、E峰减速时间（MD=-35.74，95%CI：-44.81～-26.66，P＜0.000 01）、等容舒张时间（MD=-10.24，95%CI：-16.69～-3.80，P＜0.000 01）］。 结论中药注射液联合常规西医治疗DHF的疗效优于单纯西医治疗，但需更多高质量的多中心随机双盲对照临床研究证据进行进一步验证。
Abstract:
Objective: To assess clinical effects of conventional Western medicine combined with herbal injection in the treatment of diastolic heart failure (DHF). MethodsRandomized controlled trials (RCTs) that met the inclusion were retrieved by searching CNKI, VIP, Wanfang, CBM, PubMed, Embase and Cochrane Library, and the retrieval time ranged between January, 2011 and June, 2021. Cochrane quality evaluation form was used to assess the quality of literature, and RevMan 5.4software was utilized to perform Meta analysis. ResultsAll 16 papers were included, involving 1620 patients, among them, there were 819 cases in the treatment group and 801 cases in the control group. Meta analysis results displayed that, compared with conventional treatment of single Western medicine, the combination with herbal injection could noticeably improve cardiac function (RR=1.24, 95%CI:1.17-1.30, P<0.000 01); reduce the levels of type B natriuretic peptide (MD=-94.58, 95%CI:-132.61-56.54, P<0.000 01) and N-terminal pro-brain natriuretic peptide (NT-proBNP) (MD=-199.62, 95%CI:-279.06--120.18, P<0.000 01); increase six-minute walking distance (MD=62.25, 95%CI:45.45-79.04, P<0.000 01); and enhance left ventricular ejection fraction (MD=2.73, 95%CI:1.53-3.92, P<0.000 01); and improve ventricular diastolic function such as ratio of early diastolic blood flow velocity to late diastolic blood flow velocity (MD=0.31, 95%CI:0.21-0.42, P<0.000 01), E wave deceleration time (MD=-35.74, 95%CI:-44.81--26.66, P<0.000 01), and isovolumic relaxation time (MD=-10.24, 95%CI:-16.69--3.80, P<0.000 01). ConclusionHerbal injection combined with Conventional therapy of Western medicine is better than single Western medicine in the treatment of DHF, while more high-quality multi-center randomized double-blind controlled clinical studies are needed to verify the conclusion.

相似文献/References:

[1]蒋英蓝,曾敬怀△,李荣,等.我院41例中药注射液不良反应及相关性分析[J].西部中医药,2013,26(01):68.
　JIANG Yinglan,ZENG Jinghuai,LI Rong,et al.Analysis on 41 Cases of Adverse Reactions of TCM Injections and The Related Factors[J].Western Journal of Traditional Chinese Medicine,2013,26(10):68.
[2]刘 玲,殷建峰.浅谈中药注射液的不良反应与合理使用[J].西部中医药,2014,27(08):16.
　LIU Ling,YIN Jianfeng.On Rational Use and Adverse Reaction of TCM Injection[J].Western Journal of Traditional Chinese Medicine,2014,27(10):16.
[3]范玉田.对于呼吸系统疾病使用中药注射液的几点思考[J].西部中医药,2015,28(07):99.

备注/Memo

备注/Memo:
姚婷婷（1995—），女，硕士学位，医师。研究方向：心血管疾病的中西医结合治疗。陕西省重点研发计划项目（S2023-YF-YBSF-1675）；咸阳市秦创原中医药产业创新聚集区项目（L2024-QCY-ZYYJJQ-304）。
更新日期/Last Update: 2025-10-15