[1]于泽楷,赵燕,叶吴洁,等.基于PPARγ差异表达结果探讨肥胖干预效应机制的文献分析[J].西部中医药,2026,39(07):117-121.[doi:10.12174/j.issn.2096-9600.2026.07.22]
　YU Zekai,ZHAO Yan,YE Wujie,et al.A Literature Analysis of the Mechanism Underlying Obesity Intervention Effects Based on Differential Expression of PPARγ[J].Western Journal of Traditional Chinese Medicine,2026,39(07):117-121.[doi:10.12174/j.issn.2096-9600.2026.07.22]
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基于PPARγ差异表达结果探讨肥胖干预效应机制的文献分析()

《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
39
期数:
2026年07期
页码:
117-121
栏目:
二次研究
出版日期:
2026-07-12

文章信息/Info

Title:
A Literature Analysis of the Mechanism Underlying Obesity Intervention Effects Based on Differential Expression of PPARγ
作者:
于泽楷, 赵燕, 叶吴洁, 邢婧瑜, 杨亚伟
中国疾病预防控制中心，北京 100050
Author(s):
YU Zekai, ZHAO Yan, YE Wujie, XING Jingyu, YANG Yawei
Chinese Center for Disease Control and Prevention, Beijing 100050, China
关键词:
肥胖; PPAR; 基因组学; 效应机制; 文献分析
Keywords:
obesity; PPAR; genomics; mechanism of action; literature analysis
分类号:
R589.2
DOI:
10.12174/j.issn.2096-9600.2026.07.22
文献标志码:
A
摘要:
目的探讨过氧化物酶体增殖激活物受体γ（peroxisome proliferator-activated receptor γ， PPARγ）在肥胖干预中的效应机制。 方法通过检索中国知网、PubMed等数据库中肥胖和PPARγ的动物实验文献，建立相应的数据库，统计分析各项实验设计方案及实验结果情况，探索PPARγ干预肥胖的效应机制。 结果1）共纳入文献38篇，其中18篇文献研究结果显示PPARγ基因表达上调，20篇文献研究结果显示PPARγ基因表达下调；2）干预措施方面，药物干预26篇，针刺干预5篇，运动干预5篇，综合干预2篇；3）针刺对PPARγ基因表达结果的影响主要呈下调趋势；运动及综合干预对PPARγ基因表达结果的影响呈上调趋势。 结论PPARγ基因是肥胖干预机制的关键效应指标，多种干预措施对PPARγ基因均有影响，其通过双向调节实现对肥胖的干预效果，但其变化趋势尚待深入研究。
Abstract:
ObjectiveTo investigate the mechanism of peroxisome proliferator-activated receptor γ (PPARγ) in obesity intervention. MethodsBy searching the China National Knowledge Infrastructure (CNKI), PubMed and other databases for animal experimental literature on obesity and PPARγ, a corresponding database was established. The experimental design protocols and results were statistically analyzed to explore the mechanism of PPARγ in obesity intervention. Results1) A total of 38 articles were included. Among them, 18 articles reported upregulation of PPARγ gene expression, while 20 articles reported downregulation of PPARγ gene expression; 2) Regarding interventions, 26 articles involved pharmacological interventions, 5 involved acupuncture interventions, 5 involved exercise interventions, and 2 involved comprehensive interventions; 3) Acupuncture primarily showed a downregulatory effect on PPARγ gene expression, while exercise and comprehensive interventions exhibited an upregulatory effect on PPARγ gene expression. ConclusionThe PPARγ gene is a key effect indicator in the mechanism of obesity intervention. Various intervention measures have an impact on PPARγ gene expression, achieving intervention effects on obesity through bidirectional regulation. However, the trend of its changes warrants further in-depth investigation.

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备注/Memo

备注/Memo:
国家重点研发计划应用示范研究（2019YFC1710102）。于泽楷（1996—），女，硕士学位，研究实习员。研究方向：中医诊断学。
更新日期/Last Update: 2026-07-15