[1]张德骞.自拟通窍止鼽汤联合西替利嗪治疗变应性鼻炎的疗效及对TNF-α和IL-4水平的影响[J].西部中医药,2015,28(05):28-30.
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自拟通窍止鼽汤联合西替利嗪治疗变应性鼻炎的疗效及对TNF-α和IL-4水平的影响
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
28
期数:
2015年05期
页码:
28-30
栏目:
方药·药理研究
出版日期:
2015-05-15

文章信息/Info

文章编号:
1004-6852(2015)05-0028-03
作者:
张德骞
临沂市平邑人民医院耳鼻喉科,山东 临沂 273300
关键词:
变应性鼻炎TNF-αIL-4自拟通窍止鼽汤西替利嗪
分类号:
R765.21
文献标志码:
A
摘要:
目的:探讨自拟通窍止鼽汤联合西替利嗪治疗变应性鼻炎的临床疗效及对TNF-α和IL-4水平的影响。方法:将变应性鼻炎患者88例采用数字表法随机分为2组,每组44例,其中对照组单用西替利嗪治疗,观察组采取自拟通窍止鼽汤联合西替利嗪治疗,比较2组临床治疗效果、不良反应发生情况、复发率及TNF-α和IL-4水平变化。结果:观察组有效率为95.45%,高于对照组的77.27%,2组比较差异具有统计学意义(P<0.05);观察组治疗后TNF-α和IL-4水平分别为(1.29±0.29)ng/mL和(33.62±3.52)pg/mL,均低于治疗前的(3.24±0.38)ng/mL和(50.51±3.83)pg/mL,且低于对照组治疗后的(2.47±0.32)ng/mL和(42.07±3.77)pg/mL,差异具有统计学意义(P<0.05);观察组不良反应发生率和复发率分别为6.82%和9.09%,低于对照组的15.91%和22.73%(P<0.05)。结论:自拟通窍止鼽汤联合西替利嗪可有效改善患者临床症状及免疫状态,且不良反应及复发率低。

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备注/Memo

备注/Memo:
作者简介:张德骞(1977—),男,主治医师。研究方向:耳鼻喉疾病的诊治。
更新日期/Last Update: 2015-05-15