[1]邵建兵,汪燕,王加林.麝香保心丸治疗冠心病急性心肌梗死44例[J].西部中医药,2017,30(12):61-64.
 SHAO Jianbin,WANG Yan,WANG Jialin.SheXiang BaoXin Pills in Treating 44 Cases of Acute Myocardial Infarction of Coronary Heart Disease[J].Western Journal of Traditional Chinese Medicine,2017,30(12):61-64.
点击复制

麝香保心丸治疗冠心病急性心肌梗死44例
分享到:

《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
30
期数:
2017年12期
页码:
61-64
栏目:
报道·临证经验
出版日期:
2017-12-15

文章信息/Info

Title:
SheXiang BaoXin Pills in Treating 44 Cases of Acute Myocardial Infarction of Coronary Heart Disease
文章编号:
1004-6852(2017)12-0061-04
作者:
邵建兵汪燕王加林
如皋市人民医院,江苏 如皋 226500
Author(s):
SHAO Jianbin WANG Yan WANG Jialin
Rugao Municipality People′s Hospital, Rugao 226500, China
关键词:
心肌梗死急性冠心病麝香保心丸心功能黏附分子
Keywords:
myocardial infarction acute coronary heart disease SheXiang BaoXin pills heart function adhesion molecule
分类号:
R542.2+2
文献标志码:
B
摘要:
目的:观察麝香保心丸辅助治疗对冠心病(CHD)急性心肌梗死(AMI)患者心功能的影响及其黏附分子层面作用机制。方法:将88例患者随机分为观察组、对照组各44例。对照组予以AMI常规西医治疗,观察组在对照组基础上加用麝香保心丸治疗,疗程4周。比较2组治疗前后中医临床证候评分、心功能相关指标、血清细胞间黏附分子1(ICAM-1)、血管细胞黏附分子1(VCAM-1)水平及不良事件(MACE)发生率。结果:总有效率观察组为88.64%,对照组为72.73%,2组比较差异有统计学意义(P<0.05)。中医证候积分治疗前后2组组内比较,差异有统计学意义(P<0.05);治疗后2组组间比较,差异也有统计学意义(P<0.05)。左室射血分数(LVEF)、左室舒张末期容积(LVEDV)、左室收缩末期容积(LVESV)治疗前后2组组内比较,差异有统计学意义(P<0.05);治疗后2组组间比较,差异也有统计学意义(P<0.05)。肌酸激酶同工酶(CK-MB)、脑钠肽(cTnⅠ)及肌红蛋白I(BNP)水平治疗前后2组组内比较,差异有统计学意义(P<0.05);治疗后2组组间比较,差异也有统计学意义(P<0.05)。血清ICAM-1、VCAM-1水平治疗前后2组组内比较,差异有统计学意义(P<0.05);治疗后2组组间比较,差异也有统计学意义(P<0.05)。随访3个月,MACE发生率观察组为4.55%,对照组为15.91%,2组比较差异有统计学意义(P<0.05)。结论:麝香保心丸辅助治疗CHD后AMI疗效确切,其作用机制可能是下调血清ICAM-1、VCAM-1而抑制炎性反应所致心肌损伤,改善心功能。
Abstract:
Objective: To survey the effects of SheXiang BaoXin pills as adjunctive therapy (AT) on heart function of the patients with acute myocardial infarction (AMI) of coronary heart disease (CHD) and the mechanism in adhesion molecule layer. Methods: All 88 patients were randomized into the observation group and the control group equally. The control group accepted AMI conventional therapy of western medicine, and the observation group took SheXiang BaoXin pills on the foundation of the treatment the control group received, the course was four weeks. The incidence of major adverse cardiac events (MACE), the levels of serum intercellular adhesion molecule-1(ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), the related indexes of heart function, and TCM clinical syndrome scales of both groups were compared before and after treating. Results: Total effective rate of the observation group was 88.64%, higher than 72.73% of the control group, and the difference had statistical meaning (P<0.05). The difference was statistically significant in the comparisons of TCM syndrome scales before and after treating within two groups (P<0.05), there was a significant difference in the comparison between both groups after treating (P<0.05). The difference was statistically significant in the comparisons of LVEF, LVEDV and LVESV within two groups before and after treating (P<0.05), there was a significant difference in the comparison between both groups after treating(P<0.05). The difference wasstatistically significant in the comparisons of the levels of CK-MB, cTn Ⅰ and BNP before and after treating within two groups (P<0.05), there was significant difference in the comparisons between both groups after treating (P<0.05). The difference was a statistically significant in the comparisons of the levels of ICAM-1 and VCAM-1 before and after treating within two groups (P<0.05), there was a significant difference in the comparisons between both groups after treating (P<0.05). After following up for three months, the incidence of MACE in the observation group was 4.55%, lower than 15.91% of the control group, and there was significant difference between both groups (P<0.05).Conclusion: SheXiang BaoXin pills as AT for AMI of CHD could obtain definite effects, and its mechanism might be related to myocardial damage induced by inhibiting inflammatory reaction through down regulation the levels of ICAM-1 and VCAM-1, as well as to improve heart function.

相似文献/References:

[1]张永全,张惠玉,仝树坡,等.急性脑梗死肝阳暴亢证患者血脂及经颅多普勒检查结果的相关性研究[J].西部中医药,2011,24(11):38.
[2]王凤清,刘艳春.艾迪注射液联合CAG方案治疗老年急性髓细胞白血病40例疗效观察[J].西部中医药,2012,25(12):85.
 WANG Feng-qing,LIU Yan-chun.Observation on AiDi Injection and CAG Plan in Treating 40 Cases of Senile Acute Myelocytic Leukemia[J].Western Journal of Traditional Chinese Medicine,2012,25(12):85.
[3]康庄.自拟中风活血化痰汤对急性脑梗死患者血清NSE、BDNF 水平的影响[J].西部中医药,2013,26(02):22.
 KANG Zhuang.Effects of Self-made ZhongFeng HuoXue HuaTanTang on Contents of Serum NSE and BDNF in Patients with Acute Cerebral Infarction[J].Western Journal of Traditional Chinese Medicine,2013,26(12):22.
[4]李雅娟.急性重症胰腺炎62例临床护理干预观察[J].西部中医药,2013,26(03):115.
 LI Yajuan.Observation on Nursing Intervention for 62 Patients with Acute Severe Pancreatitis[J].Western Journal of Traditional Chinese Medicine,2013,26(12):115.
[5]张世祥,贾兴梅,高鹏,等.中西医结合治疗急性重症胰腺炎18例临床研究[J].西部中医药,2013,26(05):102.
 ZHANG Shixiang,JIA Xingmei,GAO Peng,et al.Clinical Study on Integrative Medicine in Treating 18 Cases of Severe Acute Pancreatitis[J].Western Journal of Traditional Chinese Medicine,2013,26(12):102.
[6]孙志江,王映珍,徐庆杰.大黄内服配合芒硝外敷治疗重症急性胰腺炎患者43例[J].西部中医药,2012,25(08):70.
 SUN Zhi-jiang,WANG Ying-zhen,XU Qing-jie.DaHuang for Oral Administration Combined with MangXiao for External Use in Treating 43 Patients with Severe Acute Pancreatitis[J].Western Journal of Traditional Chinese Medicine,2012,25(12):70.
[7]张勇.四妙永安汤加味治疗急性痛风性关节炎140例[J].西部中医药,2012,25(07):59.
 ZHANG Yong.Clinical Observation on Modified SiMiao YongAnTang in Treating 140 Cases of Acute Gouty Arthritis[J].Western Journal of Traditional Chinese Medicine,2012,25(12):59.
[8]张伟.大承气汤加味胃管注入治疗急性胰腺炎临床观察[J].西部中医药,2013,26(08):80.
 ZHANG Wei.Clinical Observation on Treatment for Acute Pancreatitis by Injecting Modified DaChengQiTang through Stomach Tube[J].Western Journal of Traditional Chinese Medicine,2013,26(12):80.
[9]刘康乐.中西药物联用治疗小儿急性支气管炎86例[J].西部中医药,2013,26(08):90.
 LIU Kangle.Clinical Observation on Treating 86 Cases of Children Suffering from Acute Bronchitis with Integrative Medicine[J].Western Journal of Traditional Chinese Medicine,2013,26(12):90.
[10]王建华.中医辨证护理对急性阑尾炎患者协同增效及心理状态的影响[J].西部中医药,2012,25(05):98.
 WANG Jian-hua.Synergistic Effect and Influence on Psychological States of Dialectical Nursing in Patients with Acute Appendicitis[J].Western Journal of Traditional Chinese Medicine,2012,25(12):98.
[11]胡兰文,徐盛开,范玲莉.老年人急性心肌梗死的临床特征及中医证型分析[J].西部中医药,2013,26(06):44.
 HU Lanwen,XU Shengkai,FAN Lingli.Clinical Characteristics and Patterns Analysis of Acute Myocardial Infarction in the Elderly[J].Western Journal of Traditional Chinese Medicine,2013,26(12):44.
[12]陈少兰,徐胜珍△.中西医结合护理对急性心肌梗死患者康复效果的影响[J].西部中医药,2014,27(04):129.
 CHEN Shaolan,XU Shengzhen.Influence of Nursing on the Patients with Acute Myocardial Infarction at Recovery Stage by Integrative Medicine[J].Western Journal of Traditional Chinese Medicine,2014,27(12):129.
[13]魏傲,李强,丁玲,等.参芎注射液对急性非ST段抬高型心肌梗死患者外周血Th17及Treg细胞亚群的影响[J].西部中医药,2022,35(06):107.[doi:10.12174/j.issn.2096-9600.2022.06.26]
 WEI Ao,LI Qiang,DING Ling,et al.Effects of Shenxiong Injection on Th17 and Treg Cells Subsets in Peripheral Blood in Patients with Acute Non-ST-Segment Elevation Myocardial Infarction[J].Western Journal of Traditional Chinese Medicine,2022,35(12):107.[doi:10.12174/j.issn.2096-9600.2022.06.26]

备注/Memo

备注/Memo:
收稿日期:2017-06-06 作者简介:邵建兵(1971—),男,副主任药师。研究方向:药理药剂临床。
更新日期/Last Update: 2017-12-15