[1]胥瑞婷,马音,朱炜炜.榄香烯抗肿瘤作用的机制研究现状[J].西部中医药,2022,35(05):152-156.[doi:10.12174/j.issn.2096-9600.2022.05.35]
　XU Ruiting,MA Yin,ZHU Weiwei.Current State of Anti-tumor Mechanism of Elemene[J].Western Journal of Traditional Chinese Medicine,2022,35(05):152-156.[doi:10.12174/j.issn.2096-9600.2022.05.35]
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榄香烯抗肿瘤作用的机制研究现状
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
35
期数:
2022年05期
页码:
152-156
栏目:
研究进展
出版日期:
2022-05-15

文章信息/Info

Title:
Current State of Anti-tumor Mechanism of Elemene
作者:
胥瑞婷, 马音, 朱炜炜
四川大学华西医院临床药学部，四川 成都 610041
Author(s):
XU Ruiting, MA Yin, ZHU Weiwei
Department of Clinical Pharmacy, West China School of Medicine/West China Hospital, Sichuan University, Chengdu 610041, China
关键词:
榄香烯; 抗肿瘤; 作用机制; 基础研究
Keywords:
elemene; anti-tumor; mechanism; basic study
分类号:
R274
DOI:
10.12174/j.issn.2096-9600.2022.05.35
文献标志码:
A
摘要:
从直接抑制肿瘤细胞生长、诱导肿瘤细胞凋亡、诱导肿瘤细胞分化、抑制肿瘤细胞侵袭和迁移、调节机体免疫功能、抗血管生成、逆转肿瘤细胞多药耐药及放化疗增敏作用8方面探讨榄香烯抗肿瘤的作用机制，指出榄香烯（Elemene）是从传统中草药姜科植物温郁金（温莪术）中提取的萜烯类化合物，具有抗瘤谱广，临床疗效确切，毒副作用小等特点，同时榄香烯不同于传统的细胞毒性化疗药物，其在发挥直接抗肿瘤作用的基础上，还能起到逆转肿瘤细胞耐药、抑制转移、提高机体免疫力、与放化疗联用具有减毒增效等作用。
Abstract:
The mechanism of anti-tumor effects of elemene is discussed from eight aspects: directly inhibiting the growth of tumor cells, inducing the apoptosis of tumor cells, inducing tumor cell differentiation, inhibiting the invasion and migration of tumor cells, regulating immunologic function of the body, antiangiogenesis, reversing multidrug resistance and chemoradiotherapy sensitization, it is pointed out that elemene is a terpene compound extracted from the traditional Chinese herbal medicine zingiberaceae Wenyujin (curcuma aromatica Salisb), it has the characteristics of wide anti-tumor spectrum, definite clinical curative effect and small toxic and side effects, meanwhile, elemene is different from traditional cytotoxic chemotherapeutic drugs, it can reverse drug resistance of tumor cells, inhibit metastasis and improve immunity based on exerting direct anti-tumor effects, it has the effects of reducing toxicity and increasing efficiency when combined with radiotherapy and chemotherapy.

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备注/Memo

备注/Memo:
胥瑞婷（1989—），女，药师。研究方向：药品合理用药。
更新日期/Last Update: 2022-06-24