[1]石洲宝,陈长浩,高娜,等.安神二号胶囊对慢性精神分裂症患者认知和社会功能的影响[J].西部中医药,2015,28(04):1-3.
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安神二号胶囊对慢性精神分裂症患者认知和社会功能的影响
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
28
期数:
2015年04期
页码:
1-3
栏目:
出版日期:
2015-04-15

文章信息/Info

文章编号:
1004-6852(2015)04-0001-03
作者:
石洲宝，陈长浩，高娜，刘成松，刘敏科，黄生辉
甘肃中医学院附属医院，甘肃 兰州 730020
关键词:
精神分裂症; 慢性; 安神胶囊; 维思通; 认知; 社会功能
分类号:
R749.3
文献标志码:
A
摘要:
目的：探讨安神胶囊对慢性精神分裂症患者认知和社会功能的影响。方法：采用随机、双盲、双模拟试验方法，将200例患者随机分为观察组和对照组各100例，观察组口服安神胶囊，4粒/次，3次/d；对照组口服维思通，1～1.5 mg/d，2组均治疗8周。于基线和治疗8周末分别计算认知功能评定量表（WCST）评分、社会功能量表（SDSS)评分；于治疗前，治疗第2、4、6、8周分别计算阳性症状量表（SAPS）评分、阴性症状量表（SANS）评分、临床总体印象量表（CGI）评分，并以药物副反应量表（TESS)评定药物的副反应。结果：治疗第8周末，2组SAPS、SANS及SDSS评分均较基线降低，WCST指标中除了观察组持续应答数外均获改善，差异均有统计学意义（P＜0.05）；观察组SANS、SAPS评分的降低较对照组更为明显（P＜0.05)。安神胶囊组WCST各指标改善较对照组明显（P＜0.05)。SANA有效率、CGI临床进步率观察组分别为79.9%、86.6%，对照组分别为85.3%、89.3%,2组比较差异均无统计学意义（P＞0.05)。结论：安神胶囊对慢性精神分裂症患者认知和社会功能的改善更为有效，且副反应小。

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备注/Memo

备注/Memo:
*基金项目：甘肃省中医药科研项目（编号GZK-2013-33）。作者简介：石洲宝(1965—)，男，硕士研究生导师，副主任医师。研究方向：精神（心理）障碍的临床诊治。
更新日期/Last Update: 2015-04-15