[1]丁宁,高卫萍△.类风湿性关节炎与干眼的相关性研究[J].西部中医药,2018,31(03):1-5.
　DING Ning,GAO Weiping.Study on the Correlation of Rheumatoid Arthritis with Xeroma[J].Western Journal of Traditional Chinese Medicine,2018,31(03):1-5.
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类风湿性关节炎与干眼的相关性研究()
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
31
期数:
2018年03期
页码:
1-5
栏目:
出版日期:
2018-03-15

文章信息/Info

Title:
Study on the Correlation of Rheumatoid Arthritis with Xeroma
文章编号:
1004-6852(2018)03-0001-05
作者:
丁宁，高卫萍△
南京中医药大学，江苏 南京 210046
Author(s):
DING Ning, GAO Weiping△
Nanjing University of Chinese Medicine, Nanjing 210046, China
关键词:
类风湿性关节炎; 干眼; 辨证分型; 实验室检查; 性别; 病程
Keywords:
rheumatoid arthritis;  xeroma;  syndrome differentiation and patterns;  lab tests;  the gender;  duration
分类号:
R593
文献标志码:
A
摘要:
目的：探讨类风湿性关节炎(RA)与干眼的相关临床特点。方法：对46例RA患者进行问卷调查同时通过眼表检查确诊干眼患者42例（84眼），然后对其相关因素进行统计分析。结果：干眼与RA患者的病程、年龄有相关性。RA继发性干眼泪液分泌时间(SIT)、眼部症状评分在抗SSA抗体阳性和抗SSA抗体阴性患者中存在显著差异（P＜0.05）；抗SSB抗体阳性患者SIT较抗SSB抗体阴性患者低，眼部症状评分高，差异有统计学意义（P＜0.05）；角膜荧光素染色(FL)评分类分湿因子(RF)阳性患者较RF阴性患者高，差异有统计学意义（P＜0.05）；C反应蛋白(CRP)阳性患者泪膜破裂时间(BUT)较CRP阴性患者长，差异有统计学意义（P＜0.05）；FL、BUT、SIT及眼部症状评分血沉(ESR)阳性与ESR阴性患者比较差异无统计学意义（P＞0.05）；RA继发干眼中医辨证分型高发前3位中肝肾亏虚证占总例数的40.5%、痰瘀痹阻证占19.0%、湿热痹阻占16.7%，风湿痹阻证患者SIT时间最长，肝肾亏虚证患者眼部主观症状最明显。结论:RA患者应常规做干眼检查，应给予早期干预，并结合相关指标及辨证分型给予治疗和控制。
Abstract:
Objective: To discuss clinical features of the correlation of rheumatoid arthritis(RA) with xeroma. Methods: All 42 patients (84 eyes) were diagnosed with xeroma by questionnaire of RA patients and ocular surface examination, and the related factors were statistically analyzed. Results: Xeroma was related to the gender and the course of RA patients. The significant difference existed in the comparisons of Schirmer I test(SIT) of RA patients with secondary xeroma and the scores of eye symptoms between the patients with positive and negative anti-SSA antibody(P＜0.05); positive anti-SSB antibody patients was lower than negative anti-SSB antibody patients in SIT, while higher than negative antibody patients in the scores of eye symptoms, and the difference had statistical meaning (P＜0.05); corneal fluorescein staining(FL) scales of positive rheumatoid factor(RF) patients were higher than these of negative RF patients, and the difference showed statistical meaning (P＜0.05); tear break-up time (BUT) of positive C-reactive protein(CRP) patients was longer than that of the negative CRP ones, and the difference was statistically significant (P＜0.05); while the difference had no statistical meaning in the comparisons of FL, BUT, SIT and the scores of eye symptoms between the patients with positive and negative ESR(P＞0.05). The first three patterns of secondary xeroma of RA patients: liver kidney deficiency pattern secondary xeroma of RA patients occupied 40.5% of total case number, phlegm-stagnation obstruction pattern held 19.0%, damp-heat obstruction held 16.7%, SIT of the patients of wind-damp obstruction pattern was the longest, eye subjective symptoms of the patients of liver kidney deficiency pattern was the most obvious. Conclusion: Dry eye examination should be performed for RA patients as a matter of routine, early intervention, the treatment and control should be given based on the related indexes and syndrome differentiation and patterns.

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备注/Memo

备注/Memo:
收稿日期：2017-04-10 *基金项目：江苏省中医药局科研专项课题(编号ZX2016C1)。 作者简介：丁宁(1992—)，女，在读硕士研究生。研究方向：中医眼科学。 △通讯作者：高卫萍（1963—)，女，博士研究生导师，博士学位，主任医师。研究方向：中医眼科学。
更新日期/Last Update: 2018-03-15