[1]滕雅娟,张燕,谭志敏,等.丹参酮联合优甲乐对桥本甲状腺炎伴甲状腺功能减退患者免疫功能的影响[J].西部中医药,2019,32(03):102-105.
　TENG Yajuan,ZHANG Yan,TAN Zhimin,et al.Effects of Tanshinone and Euthyrox on Immunologic Function of Hashimoto's Thyroiditis Accompanying Hypothyroidism[J].Western Journal of Traditional Chinese Medicine,2019,32(03):102-105.
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丹参酮联合优甲乐对桥本甲状腺炎伴甲状腺功能减退患者免疫功能的影响
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
32
期数:
2019年03期
页码:
102-105
栏目:
出版日期:
2019-03-15

文章信息/Info

Title:
Effects of Tanshinone and Euthyrox on Immunologic Function of Hashimoto's Thyroiditis Accompanying Hypothyroidism
文章编号:
1004-6852(2019)03-0102-04
作者:
滕雅娟1，张燕1，谭志敏1，杨慧颖1，曹华1，盛正妍2
1 上海市第一人民医院宝山分院内分泌科，上海200940； 2 上海市第一人民医院内分泌代谢科
Author(s):
TENG Yajuan1, ZHANG Yan1, TAN Zhimin1, YANG Huiying1, CAO Hua1, SHENG Zhengyan2
1 Endocrinology Department, Baoshan Branch, Shanghai City the First People's Hospital, Shanghai 200940, China; 2 Department of Endocrinology and Metabolism, Shanghai City the First People's Hospital
关键词:
桥本甲状腺炎; 甲状腺功能减退; 细胞免疫; 细胞因子; 丹参酮
Keywords:
Hashimoto's thyroiditis;  hypothyroidism;  cellular immunity;  cytokines;  tanshinone
分类号:
R581.4
摘要:
目的：观察丹参酮联合优甲乐治疗桥本甲状腺炎(HT)伴甲状腺功能减退(甲减)的疗效及其对患者免疫功能的影响。方法：将HT合并甲减患者84例根据治疗方法的不同分为观察组和对照组各42例。对照组予优甲乐治疗，观察组在对照组治疗的基础上予丹参酮治疗。观察2组患者疗效及治疗前后游离甲状腺素T3、T4(FT3、FT4)、促甲状腺激素(TSH)、甲状腺过氧化物酶抗体(TPO-AB)、白细胞介素(IL-10、IL-12、IL-4)和γ干扰素(IFN-γ)、CD3+、CD4+、CD8+和CD4+/CD8+水平。结果：总有效率观察组为95.2%，高于对照组的76.2%，2组比较差异有统计学意义(χ2=4.764，P＜0.05)。治疗后2组患者FT3、FT4、IL-10、IL-4、CD3+和CD8+水平较治疗前升高(P＜0.01)，TSH、TPO-AB、IFN-γ、IL-12、CD4+和CD4+/CD8+水平降低(P＜0.01)，观察组变化程度较对照组明显(P＜0.01)。结论：丹参酮联合优甲乐能够缓解HT伴甲减患者机体Th1/Th2漂移，纠正机体免疫紊乱。
Abstract:
Objective: To observe clinical effects of tanshinone joined with euthyrox in treating Hashimoto's thyroiditis (HT) accompanying hypothyroidism and its effects on immunologic function. Methods: According to different therapeutic methods， 84 patients suffering HT accompanying hypothyroidism were allocated into the observation group and the control group, 42 cases each group. The control group took euthyrox, and the observation group was given tanshinone based on euthyrox. To observe clinical effects of both groups, the levels of FT3, FT4, TSH, TPO-AB, IL-10, IL-12, IL-4, IFN-γ, CD3+, CD4+ and CD4+/CD8+. Results: Total effective rate of the observation group was 95.2%, superior to 76.2% of the control group, and the difference had statistical meaning ( χ2=4.764, P＜0.05). After treating, the levels of FT3, FT4, IL-10, IL-4, CD3+ and CD8+ rose compared with before treating (P＜0.01); the levels of TSH, TPO-AB, IFN-γ, IL-12, CD4+ and CD4+/CD8+ lowered (P＜0.01), the changes of the observation group were more notable than the control group (P＜0.01). Conclusion: Tanshinone joined with euthyrox in treating HT accompanying hypothyroidism could relieve Th1/Th2 shift and correct immune disorders.

参考文献/References:

B

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备注/Memo

备注/Memo:
收稿日期：2018-02-20 作者简介：滕雅娟(1978—)，女，副主任医师。研究方向：甲状腺疾病及糖尿病的研究。
更新日期/Last Update: 2019-03-15