[1]畅辉,岳黎明△.中西药物联用治疗气阴两虚型冠心病心绞痛75例[J].西部中医药,2019,32(08):98-100.
　CHANG Hui,YUE Liming.Treating 75 Patients with Coronary Heart Disease Angina Pectoris of Qi-yin Deficiency Pattern by the Combination of Western Medicine and Herbs[J].Western Journal of Traditional Chinese Medicine,2019,32(08):98-100.
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中西药物联用治疗气阴两虚型冠心病心绞痛75例
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
32
期数:
2019年08期
页码:
98-100
栏目:
出版日期:
2019-08-15

文章信息/Info

Title:
Treating 75 Patients with Coronary Heart Disease Angina Pectoris of Qi-yin Deficiency Pattern by the Combination of Western Medicine and Herbs
文章编号:
1004-6852(2019)08-0098-03
作者:
畅辉，岳黎明△
陕西中医药大学附属医院心血管二科，陕西 咸阳 712000
Author(s):
CHANG Hui, YUE Liming△
The Second Cardiovascular Department, Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang 712000, China
关键词:
气阴两虚型; 冠心病; 心绞痛; 临床疗效
Keywords:
Qi-yin deficiency pattern;  CHD;  AP;  clinical effects
分类号:
R541.4
文献标志码:
B
摘要:
目的：观察通脉养心丸联合单硝酸异山梨酯片治疗气阴两虚型冠心病心绞痛的临床疗效。方法：将150例患者按照就诊顺序随机分为观察组和对照组，每组75例。对照组给予常规抗心绞痛药物治疗及基础疾病治疗，观察组在对照组的基础上加服通脉养心丸，40丸/次，2次/d。2组均连续治疗3个月。观察2组临床疗效、不良反应、治疗前后颈动脉内中膜(IMT)厚度、血浆同型半胱氨酸(Hcy)浓度，以及治疗后1周内心绞痛发作次数、心绞痛持续时间、硝酸甘油用量。结果：总有效率观察组为96.00%，对照组为85.33%，2组比较差异有统计学意义(P＜0.05)。不良反应发生率观察组为5.33%，对照组为14.67%，2组比较差异有统计学意义(P＜0.05)。IMT及Hcy水平治疗前后2组组内比较，差异有统计学意义(P＜0.05)；治疗后2组组间比较差异也有统计学意义(P＜0.05)。治疗后1周内心绞痛发作次数、心绞痛单次发作持续时间及周硝酸甘油用量2组比较，差异有统计学意义(P＜0.05)。结论：通脉养心丸联合单硝酸异山梨酯片治疗气阴两虚型冠心病心绞痛临床疗效显著，能够改善患者临床指标，减少患者心绞痛发作次数及药物用量，同时具有较高的安全性。
Abstract:
Objective: To survey curative effects of Tongmai Yangxin pills combined with isosorbide mononitrate tablets in the treatment for coronary heart disease angina pectoris(CHD-AP) of Qi-yin deficiency pattern. Methods: A total of 150 patients were randomized into the experiment group and the control group according to the visiting order, 75 cases each group, the control group accepted conventional anti-angina medicine and basic disease medicine, the observation group took Tongmai Yangxin pills, 40 pills each time, twice each day. Both groups were treated for three months consecutively. To observe clinical effects, adverse reaction, intima-media wall thickness (IMT) before and after treating, the concentrations of homocysteline (Hcy) in the plasma, the frequency of AP attack, AP duration and the dose of glyceryl trinitrate within one week after treating. Results: Total effective rate of the observation group was 96.00%, higher than 85.33% of the control group, and the difference was statistically significant (P＜0.05). Adverse reaction incidence of the observation group was 5.33%, lower than 14.67% of the control group, and the difference showed statistical meaning (P＜0.05). The difference was statistically significant in the level of Hcy and IMT within two groups before and after treating (P＜0.05); the difference had statistical meaning between both groups after treating (P＜0.05). The difference had statistical meaning in the frequency of AP attack, AP duration each time and weekly dose of glyceryl trinitrate within one week after treating (P＜0.05). Conclusion: Tongmai Yangxin pills combined with isosorbide mononitrate tablets could obtain notable effects in the treatment for CHD-AP of Qi-yin deficiency pattern, it could improve clinical indexes, reduce the frequency of AP attack and the medication dose, and possess higher safety simultaneously.

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备注/Memo

备注/Memo:
收稿日期：2018-09-25作者简介：畅辉(1973—)，男，副主任医师。研究方向：冠心病的中西医结合治疗。△通讯作者：岳黎明(1975—)，男，副主任医师。研究方向：冠心病的中西医结合治疗。
更新日期/Last Update: 2019-08-15