[1]戴芳,陆智华,朱闽,等.壮药前列舒外洗剂对IIIA型前列腺炎患者相关细胞因子表达水平的影响[J].西部中医药,2021,34(08):136-138.[doi:10.12174/j.issn.2096-9600.2021.08.32]
　DAI Fang,LU Zhihua,ZHU Min,et al.Influence of Zhuang Medicine Qianlieshu Lotion on the Expression of the Related Cytokines in Patients with ⅢA Type Prostatitis[J].Western Journal of Traditional Chinese Medicine,2021,34(08):136-138.[doi:10.12174/j.issn.2096-9600.2021.08.32]
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壮药前列舒外洗剂对IIIA型前列腺炎患者相关细胞因子表达水平的影响
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
34
期数:
2021年08期
页码:
136-138
栏目:
出版日期:
2021-08-15

文章信息/Info

Title:
Influence of Zhuang Medicine Qianlieshu Lotion on the Expression of the Related Cytokines in Patients with ⅢA Type Prostatitis
作者:
戴芳1, 陆智华2, 朱闽1, 蒋建玲2, 买鹏宇2, 张泽朝2, 林泽森2
1.广西中医药大学附属瑞康医院，广西 南宁 530011
2.广西中医药大学研究生学院
Author(s):
DAI Fang1, LU Zhihua2, ZHU Min1, JIANG Jianling2, MAI Pengyu2, ZHANG Zechao2, LIN Zesen2
1.Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine, Nanning 530011, China
2.Graduate School, Guangxi University of Chinese Medicine
关键词:
前列腺炎; ⅢA型; 壮医药; 细胞因子; 临床疗效; 民族医药
Keywords:
ⅢA type prostatitis; medicine; cytokine; clinical effects; ethnic medicine
分类号:
R697+.33
DOI:
10.12174/j.issn.2096-9600.2021.08.32
摘要:
目的观察壮药前列舒外洗剂对ⅢA型慢性前列腺炎（chronic prostatitis，CP）（湿热挟瘀证）患者相关细胞因子表达水平的影响。 方法将80例CP患者随机均分为观察组和对照组，每组40例。观察组使用壮药前列舒外洗剂联合盐酸坦洛新缓释片治疗，对照组予盐酸坦洛新缓释片治疗，两组均以28天为1个疗程。比较两组总有效率、慢性前列腺炎症状评分表（national institutes of health chronic prostatitis symptom index，NIH-CPSI）评分、证候评分及前列腺液中白细胞（expressed prostatic secretious white blood cell，EPS-WBC）、白细胞介素2（interleukin-2，IL-2）、白细胞介素6（interleukin-6，IL-6）和肿瘤坏死因子α（tumor necrosis factor-α，TNF-α）的表达水平。 结果观察组总有效率［86.84%（33/38）］优于对照组［78.38%（29/37）］（P＜0.05）；两组NIH-CPSI评分、证候评分及EPS-WBC、IL-6、TNF-α水平治疗后较治疗前明显降低，IL-2水平较治疗前升高（P＜0.05），且观察组各项指标改善程度大于对照组（P＜0.05）。 结论壮药前列舒外洗剂对ⅢA型CP（湿热挟瘀证）有较好的疗效，能够在降低EPS-WBC、IL-6、TNF-α表达水平的同时提高IL-2水平，这可能是壮药前列舒外洗剂治疗ⅢA型CP（湿热挟瘀证）的机理之一。
Abstract:
ObjectiveTo survey the effects of Zhuang medicine Qianlieshu lotion on the expressions of the related cytokines in patients with ⅢA type CP of damp-heat with blood stasis pattern. MethodsEighty CP patients were randomized into the observation group and the control group, 40 cases in each group. The observa-tion group was treated by Zhuang medicine Qianlieshu lotion and Tamsulosin hydrochloride sustained release tablets, and the control group by Tamsulosin hydrochloride sustained release tablets, 28 days were one course of the treatment. To compare total effective rate, NIH-CPSI scores, TCM syndrome scores and the expressions of EPS-WBC, IL-2, IL-6 and TNF-α in prostatic fluid between both groups. ResultsTotal effective rate of the observation group was 86.84% (33/38), superior to 78.38% (29/37) of the control group (P<0.05); NIH-CPSI scores, TCM syndrome scores and the levels of EPS-WBC, IL-6 and TNF-α of both groups lowered notably compared with these before treating, and the level of IL-2 rose than that before treating, and the improvements of the observation group were greater than these of the control group (P<0.05). ConclusionZhuang medicine Qianlieshu lotion owns better clinical effects in the treatment of ⅢA type CP of damp-heat with blood stasis pattern, it could lower the expressions of EPS-WBC, IL-6 and TNF-α, simultaneously raise the level of IL-2, and it might be one of the mechanisms of Zhuang medicine Qianlieshu lotion in treating ⅢA type CP of damp-heat with blood stasis pattern.

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备注/Memo

备注/Memo:
戴芳（1978—），女，副主任技师。研究方向：男科疾病的临床研究。广西科技攻关计划（桂科攻14124003-10-3）；广西壮族自治区卫生厅自筹课题（Z20170745）。
更新日期/Last Update: 2021-08-15