[1]朱梦佳,蔡萌强,杨慧萍,等.小柴胡汤联合恩替卡韦治疗慢性乙型病毒性肝炎的Meta分析[J].西部中医药,2021,34(12):62-66.[doi:10.12174/j.issn.2096-9600.2021.12.17]
　ZHU Mengjia,CAI Mengqiang,YANG Huiping,et al.Meta Analysis of Xiaochaihu Decoction and Entecavir in the Treatment of Chronic Hepatitis B[J].Western Journal of Traditional Chinese Medicine,2021,34(12):62-66.[doi:10.12174/j.issn.2096-9600.2021.12.17]
点击复制

小柴胡汤联合恩替卡韦治疗慢性乙型病毒性肝炎的Meta分析
分享到：

《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
34
期数:
2021年12期
页码:
62-66
栏目:
出版日期:
2021-12-15

文章信息/Info

Title:
Meta Analysis of Xiaochaihu Decoction and Entecavir in the Treatment of Chronic Hepatitis B
作者:
朱梦佳, 蔡萌强, 杨慧萍, 王淋, 赵文霞
河南中医药大学第一附属医院,河南 郑州 450000
Author(s):
ZHU Mengjia, CAI Mengqiang, YANG Huiping, WANG Lin, ZHAO Wenxia
The First Affiliated Hospital of Henan University of Chinese Medicine, Zhengzhou 450000, China
关键词:
小柴胡汤; 恩替卡韦; 慢性乙型肝炎; 随机对照试验; Meta分析
Keywords:
decoction; entecavir; CHB; RCT; Meta analysis
分类号:
R512.6+2
DOI:
10.12174/j.issn.2096-9600.2021.12.17
文献标志码:
A
摘要:
目的系统评价小柴胡汤联合恩替卡韦治疗慢性乙型肝炎（chronic hepatitis B，CHB）的有效性，为临床治疗提供循证参考。 方法计算机检索7个中英文数据库，筛选小柴胡汤联合恩替卡韦治疗慢性乙型肝炎的随机对照研究（randomized controlled trial，RCT），对其进行质量评价及资料提取，并采用Review Manager 5.3进行Meta分析。 结果共纳入10项RCT，共875例，包括治疗组437例，对照组438例。治疗组血清ALT复常率（RR=1.29，95%CI［1.18，1.44］，P＜0.000 01），血清HBeAg转阴率（RR=2.27，95%CI［1.68，3.08］，P＜0.000 01），血清HBV-DNA转阴率（RR=2.40，95%CI［1.73，3.33］，P＜0.000 01），临床疗效（RR=5.88，95%CI［3.48，9.93］，P＜0.000 01），应答率（RR=2.08，95%CI［1.47，2.97］，P＜0.000 1），以上指标治疗组均优于对照组。 结论小柴胡汤联合恩替卡韦治疗CHB，能有效改善患者肝功生化复常率，提高血清HBeAg及HBV-DNA转阴率，其临床疗效及应答率明显提高。
Abstract:
ObjectiveTo systematically assess the efficacy of Xiaochaihu decoction combined with entec-avir in treating CHB, so as to provide the evidence-based reference for clinical therapy. MethodsRCT about Xiaochaihu decoction and entecavir in treating CHB was screened in seven Chinese and English databases using computer, to perform the qualty evaluation and data extraction, Review Manager 5.3 was used to perform Meta analysis. ResultsAll ten RCTs were included, involving 875 cases, including 437 cases of the treatment group and 438 cases of the control group. The results showed that the normalization rate of serum ALT of the treatment group was (RR=1.29, 95%CI[1.18, 1.44], P<0.000 01), serum HBeAg negative conversion rate (RR=2.27, 95%CI[1.68, 3.08], P<0.000 01), serum HBV-DNA negative conversion rate (RR=2.40, 95%CI[1.73, 3.33], P<0.000 01), clinical effects (RR=5.88, 95%CI[3.48, 9.93], P<0.000 01), response rate (RR=2.08, 95%CI[1.47, 2.97], P<0.00001), the treatment group was better than the control group in the indexes above. ConclusionXiaochaihu decoction combined with entecavir in treating CHB could effectively improve biochemical normalization rate of liver function, lift serum HBeAg negative conversion rate and HBV-DNA negative conversion rate, its clinical effects and response rate significantly.

相似文献/References:

[1]张永科,马天寿.小柴胡汤联合多靶点激素治疗肾病综合征60例[J].西部中医药,2014,27(10):120.
[2]丁 强,王云方△.壮健教授运用小柴胡汤治疗肺系疾病验案举隅[J].西部中医药,2016,29(02):57.
　DING Qiang,WANG Yunfang.Professor Zhuang Jian′s Effective Cases of Applying Xiao ChaiHu Tang to Pulmonary Diseases[J].Western Journal of Traditional Chinese Medicine,2016,29(12):57.
[3]张兆洲,戴恩来△.从《伤寒论》七方中探讨“去滓再煎”法的现实意义[J].西部中医药,2017,30(03):63.
　ZHANG Zhaozhou,DAI Enlai.Study on the Practical Significance of ″Deslagging and Re-Boiling″ from Seven Prescriptions in Treatise on Febrile Diseases[J].Western Journal of Traditional Chinese Medicine,2017,30(12):63.
[4]葛红娣,刘秀艳,翟力军.小柴胡汤加减对肾病综合征血清IGF-1及结合蛋白的影响[J].西部中医药,2019,32(04):1.
　GE Hongdi,LIU Xiuyan,ZHAI Lijun.Impact of Modified XiaoChaiHu Decoction on IGF-1 and Its Binding Protein in Nephrotic Syndrome[J].Western Journal of Traditional Chinese Medicine,2019,32(12):1.
[5]方坤炎,吕丽容,郭超峰.基于数据挖掘分析小柴胡汤方证关系研究[J].西部中医药,2022,35(05):80.[doi:10.12174/j.issn.2096-9600.2022.05.19]
　FANG Kunyan,LYU Lirong,GUO Chaofeng.Study on Prescription-syndrome Relationship of Xiaochaihu Decoction Based on Data Mining[J].Western Journal of Traditional Chinese Medicine,2022,35(12):80.[doi:10.12174/j.issn.2096-9600.2022.05.19]
[6]陈靖,王卉,刘晓丹,等.小柴胡汤化裁方对AD小鼠记忆认知能力及海马神经元形态的影响[J].西部中医药,2021,34(05):32.[doi:10.12174/j.issn.2096-9600.2021.05.08]
　CHEN Jing,WANG Hui,LIU Xiaodan,et al.Effects of Modified Xiaochaihu Tang on Memory and Cognitive Ability and the Morphology of Hippocampal Neurons in AD Mice[J].Western Journal of Traditional Chinese Medicine,2021,34(12):32.[doi:10.12174/j.issn.2096-9600.2021.05.08]
[7]叶苗青,唐颖慧,杨跃青,等.恩替卡韦联合乙转灵治疗乙型肝炎肝纤维化患者LSM值与中医证候积分的相关性研究[J].西部中医药,2023,36(10):112.[doi:10.12174/j.issn.2096-9600.2023.10.23]
　YE Miaoqing,TANG Yinghui,YANG Yueqing,et al.Study on the Correlation between LSM Values and TCM Syndrome Scores in Patients with Hepatitis B Hepatic Fibrosis Treated with Entecavir and Yizhuanling[J].Western Journal of Traditional Chinese Medicine,2023,36(12):112.[doi:10.12174/j.issn.2096-9600.2023.10.23]

备注/Memo

备注/Memo:
朱梦佳（1994—），女，在读硕士研究生。研究方向：消化系统疾病的中医药诊治。河南省自然科学基金（162300410183）。
更新日期/Last Update: 2021-12-15