[1]方坤炎,吕丽容,郭超峰.基于数据挖掘分析小柴胡汤方证关系研究[J].西部中医药,2022,35(05):80-84.[doi:10.12174/j.issn.2096-9600.2022.05.19]
　FANG Kunyan,LYU Lirong,GUO Chaofeng.Study on Prescription-syndrome Relationship of Xiaochaihu Decoction Based on Data Mining[J].Western Journal of Traditional Chinese Medicine,2022,35(05):80-84.[doi:10.12174/j.issn.2096-9600.2022.05.19]
点击复制

基于数据挖掘分析小柴胡汤方证关系研究
分享到：

《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
35
期数:
2022年05期
页码:
80-84
栏目:
出版日期:
2022-05-15

文章信息/Info

Title:
Study on Prescription-syndrome Relationship of Xiaochaihu Decoction Based on Data Mining
作者:
方坤炎1, 吕丽容1, 郭超峰2
1.广西中医药大学，广西 南宁 530200
2.广西中医药大学第一附属医院
Author(s):
FANG Kunyan1, LYU Lirong1, GUO Chaofeng2
1.Guangxi University of Chinese Medicine, Nanning 530200, China
2.The First Affiliated Hospital of Guangxi University of Chinese Medicine
关键词:
小柴胡汤; 方证关系; 数据挖掘; 关联规则
Keywords:
decoction; prescription-syndrome relationship; data mining; association rules
分类号:
R285
DOI:
10.12174/j.issn.2096-9600.2022.05.19
文献标志码:
A
摘要:
目的通过关联规则挖掘技术分析现代小柴胡汤医案，探索有关小柴胡汤医案基本信息特点以及方与证之间的关联关系。 方法检索中国知网（CNKI）、万方数据知识服务平台（WANFANG DATA）、维普数据库（VIP）1979—1998年期刊中小柴胡汤医案和现代图书中小柴胡汤医案，并对入选医案进行信息提取、规范化处理，建立Excel表，应用开源软件包R3.5.3分析数据。 结果共收集医案600份，男女构成比为1∶1.5；主要发病年龄为21～50岁；发病季节以春季为主；疗程主要在2周内；病因以旧疾为最；主治疾病较为广泛，以发热为主；舌苔以红舌、薄苔为主；症状体征以口苦、食欲减退为主；常见证候组合为“口苦，弦脉”“薄苔，弦脉”“食欲减退，弦脉”“白苔，弦脉”；“恶寒，弦脉-发热”“恶寒-发热”具有强关联性。 结论运用关联规则挖掘技术进行频数和关联分析，能较全面发现现代小柴胡汤的临床运用及方证特点，为临床辨证施治提供参考。
Abstract:
ObjectiveTo explore the characteristics of basic information, and the relationship between prescription and syndrome by analyzing modern medical cases of Xiaochaihu decoction through using association rule mining technology. MethodsMedical cases of Xiaochaihu decoction in journals from 1979 to 1998 and modern books were searched from CNKI, WANFANG DATA and VIP, the information of retrieved medical cases was extracted and normalized to establish Excel table, the data was analyzed by using open source software R3.5.3. ResultsA total of 600 medical cases are collected, the ratio of male to female is 1:1.5; the main onset age is between 21 and 50 years; the disease mainly attacks in the spring; the course of the treatment is within two weeks; the cause is the former affliction; the indications are wider, fever as the main symptom; tongue coating is red tongue and thin coating mainly; the symptoms and body signs are bitter mouth, decreased appetite; the common syndrome combinations are “bitter mouth and stringy pulse” “thin tongue, stringy pulse” “decreased appetite and stringy pulse” “white tongue and stringy pulse”; “aversion to cold, stringy pulse-fever” and “aversion to cold-fever” show strong correlation. ConclusionPerforming frequency and association analysis by using association rules mining technology could entirely discover clinical application and the characteristics of prescription-syndrome of modern Xiaochaihu decoction, which could provide certain reference for syndrome differentiation and treatment in clinic.

相似文献/References:

[1]张永科,马天寿.小柴胡汤联合多靶点激素治疗肾病综合征60例[J].西部中医药,2014,27(10):120.
[2]丁 强,王云方△.壮健教授运用小柴胡汤治疗肺系疾病验案举隅[J].西部中医药,2016,29(02):57.
　DING Qiang,WANG Yunfang.Professor Zhuang Jian′s Effective Cases of Applying Xiao ChaiHu Tang to Pulmonary Diseases[J].Western Journal of Traditional Chinese Medicine,2016,29(05):57.
[3]张兆洲,戴恩来△.从《伤寒论》七方中探讨“去滓再煎”法的现实意义[J].西部中医药,2017,30(03):63.
　ZHANG Zhaozhou,DAI Enlai.Study on the Practical Significance of ″Deslagging and Re-Boiling″ from Seven Prescriptions in Treatise on Febrile Diseases[J].Western Journal of Traditional Chinese Medicine,2017,30(05):63.
[4]葛红娣,刘秀艳,翟力军.小柴胡汤加减对肾病综合征血清IGF-1及结合蛋白的影响[J].西部中医药,2019,32(04):1.
　GE Hongdi,LIU Xiuyan,ZHAI Lijun.Impact of Modified XiaoChaiHu Decoction on IGF-1 and Its Binding Protein in Nephrotic Syndrome[J].Western Journal of Traditional Chinese Medicine,2019,32(05):1.
[5]朱梦佳,蔡萌强,杨慧萍,等.小柴胡汤联合恩替卡韦治疗慢性乙型病毒性肝炎的Meta分析[J].西部中医药,2021,34(12):62.[doi:10.12174/j.issn.2096-9600.2021.12.17]
　ZHU Mengjia,CAI Mengqiang,YANG Huiping,et al.Meta Analysis of Xiaochaihu Decoction and Entecavir in the Treatment of Chronic Hepatitis B[J].Western Journal of Traditional Chinese Medicine,2021,34(05):62.[doi:10.12174/j.issn.2096-9600.2021.12.17]
[6]陈靖,王卉,刘晓丹,等.小柴胡汤化裁方对AD小鼠记忆认知能力及海马神经元形态的影响[J].西部中医药,2021,34(05):32.[doi:10.12174/j.issn.2096-9600.2021.05.08]
　CHEN Jing,WANG Hui,LIU Xiaodan,et al.Effects of Modified Xiaochaihu Tang on Memory and Cognitive Ability and the Morphology of Hippocampal Neurons in AD Mice[J].Western Journal of Traditional Chinese Medicine,2021,34(05):32.[doi:10.12174/j.issn.2096-9600.2021.05.08]
[7]杨坤,甘丽华,郭超峰.吴茱萸汤治疗呕吐的方证关系研究[J].西部中医药,2024,37(05):97.[doi:10.12174/j.issn.2096-9600.2024.05.18]
　YANG Kun,GAN Lihua,GUO Chaofeng.Study on the Formulae-syndrome Relationship in the Treatment of Vomiting by Wuzhuyu Tang[J].Western Journal of Traditional Chinese Medicine,2024,37(05):97.[doi:10.12174/j.issn.2096-9600.2024.05.18]

备注/Memo

备注/Memo:
方坤炎（1993—），男，硕士学位。研究方向：经方的临床应用及方证关系研究。国家自然科学基金地区基金项目（81560820）；广西中医药大学研究生创新计划资助项目（XYJ19125）。
更新日期/Last Update: 2022-06-24