[1]董礼刚,汪红兵,张会存,等.健脾清化汤对甲硝唑耐药幽门螺杆菌外排基因hefABC表达的影响[J].西部中医药,2022,35(12):56-59.[doi:10.12174/j.issn.2096-9600.2022.12.12]
　DONG Ligang,WANG Hongbing,ZHANG Huicun,et al.Effects of Jianpi Qinghua Tang on the Expressions of Metronidazole Resistance Helicobacter pylori Genes hefABC[J].Western Journal of Traditional Chinese Medicine,2022,35(12):56-59.[doi:10.12174/j.issn.2096-9600.2022.12.12]
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健脾清化汤对甲硝唑耐药幽门螺杆菌外排基因hefABC表达的影响
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《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
35
期数:
2022年12期
页码:
56-59
栏目:
出版日期:
2022-12-15

文章信息/Info

Title:
Effects of Jianpi Qinghua Tang on the Expressions of Metronidazole Resistance Helicobacter pylori Genes hefABC
作者:
董礼刚1, 汪红兵2, 张会存3, 刘婉琼2, 王月娇2, 宋瑶2, 李一桐2, 尤佳2
1.北京中医医院延庆医院，北京 102100
2.首都医科大学附属北京中医医院
3.北京市中医研究所
Author(s):
DONG Ligang1, WANG Hongbing2, ZHANG Huicun3, LIU Wanqiong2, WANG Yuejiao2, SONG Yao2, LI Yitong2, YOU Jia2
1.Yan′qing Hospital of Beijing Hospital of Traditional Chinese Medicine, Beijing 102100, China
2.Beijing Hospital of Traditional Chinese Medicine
3.Beijing Institute of Traditional Chinese Medicine
关键词:
幽门螺杆菌; 健脾清化汤; 耐药; 外排基因hefABC
Keywords:
Helicobacter pylori; drug fast; gene hefABC
分类号:
R285.6
DOI:
10.12174/j.issn.2096-9600.2022.12.12
文献标志码:
A
摘要:
目的观察健脾清化汤对甲硝唑耐药幽门螺杆菌hefABC基因表达水平的影响，探讨健脾清化汤发挥杀菌作用的机制。 方法应用Real-time PCR技术，检测健脾清化汤作用后甲硝唑耐药幽门螺杆菌hefABC基因表达量的变化。 结果与对照组相比，各不同浓度健脾清化汤组hefA、hefC基因表达量均明显下降（P＜0.05），各组hefB基因表达量无明显差异（P＞0.05）。 结论健脾清化汤能够抑杀对甲硝唑耐药的幽门螺杆菌，其机制可能与下调耐药幽门螺杆菌外排基因hefA、hefC的表达量相关。
Abstract:
ObjectiveTo observe the effects of Jianpi Qinghua Tang on the expressions of metronidazole resistance Helicobacter pylori genes hefABC and explore the mechanism of the decoction developing its bactericidal action. MethodsReal-time PCR technology was used to detect the expressions of metronidazole resistance Helicobacter pylori genes hefABC after Jianpi Qinghua Tang acting on Hp. ResultsCompared with the control group, the expressions of hefA and hefC genes in different concentrations of Jianpi Qinghua Tang groups were reduced obviously (P<0.05), no obvious difference has been found in the expressions of hefB genes between different groups (P>0.05). ConclusionJianpi Qinghua Tang could kill metronidazole-resistance Hp, and its mechanism might be related to down regulating the expressions of hefA and hefB.

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备注/Memo

备注/Memo:
董礼刚（1990—），男，硕士学位，住院医师。研究方向：脾胃病的中医诊治。国家自然科学基金（8177150984）；北京市自然科学基金面上项目（7172098）。
更新日期/Last Update: 2022-12-15