[1]陈转艮,陈志,廖敦.经皮神经电刺激联合通络祛痹膏外敷对膝骨性关节炎疗效及关节滑液免疫细胞的影响[J].西部中医药,2024,37(08):148-152.[doi:10.12174/j.issn.2096-9600.2024.08.34]
　CHEN Zhuangen,CHEN Zhi,LIAO Dun.Clinical Effects of Transcutaneous Electrical Nerve Stimulation and Collateral-dredging Arthralgia-removing Ointment for External Application in the Treatment of Knee Osteoarthritis and Its Influence on Synovial Immune Cells[J].Western Journal of Traditional Chinese Medicine,2024,37(08):148-152.[doi:10.12174/j.issn.2096-9600.2024.08.34]
点击复制

经皮神经电刺激联合通络祛痹膏外敷对膝骨性关节炎疗效及关节滑液免疫细胞的影响
分享到：

《西部中医药》[ISSN:2096-9600/CN:62-1204/R]

卷:
37
期数:
2024年08期
页码:
148-152
栏目:
特色医疗
出版日期:
2024-08-15

文章信息/Info

Title:
Clinical Effects of Transcutaneous Electrical Nerve Stimulation and Collateral-dredging Arthralgia-removing Ointment for External Application in the Treatment of Knee Osteoarthritis and Its Influence on Synovial Immune Cells
作者:
陈转艮, 陈志, 廖敦
东莞市人民医院，广东 东莞 523059
Author(s):
CHEN Zhuan′gen, CHEN Zhi, LIAO Dun
Dongguan People's Hospital, Dongguan 523059, China
关键词:
骨性关节炎; 膝; 经皮神经电刺激; 通络祛痹膏; 扶他林; 炎症因子
Keywords:
knee osteoarthritis; transcutaneous electrical nerve stimulation; collateral-dredging arthralgia-removing ointment; diclofenac sodium enteric-coated tablets; inflammatory factors
分类号:
R274.9
DOI:
10.12174/j.issn.2096-9600.2024.08.34
文献标志码:
B
摘要:
目的探究经皮神经电刺激（transcutaneous electrical nerve stimulation，TENS）联合通络祛痹膏外敷治疗膝骨性关节炎（knee osteoarthritis，KOA）疗效及对关节滑液免疫细胞和膝关节功能的影响。 方法将KOA患者60例按随机数字表法分为对照组A、对照组B及观察组各20例。对照组A予TENS治疗，对照组B予通络祛痹膏外敷+扶他林治疗，观察组予通络祛痹膏外敷+TENS治疗，各组均治疗6周。比较3组患者治疗前后关节滑液中白细胞介素1（interleukin-1，IL-1）、白细胞介素6（interleukin-6，IL-6）、肿瘤坏死因子α（tumor necrosis factor-α，TNF-α）、干扰素γ（interferon-γ，IFN-v）、一氧化氮（nitric oxide，NO）、超氧化物歧化酶（superoxide dismutase，SOD）和丙二醛（malondialdehyde，MDA）的表达水平，并采用疼痛视觉模拟量表（visual analogue score，VAS）评分和膝关节康复量表（lysholm knee score scale，LKSS）评分评估膝关节恢复情况。 结果治疗后观察组VAS评分低于对照组A及对照组B（P＜0.05），LKSS评分高于对照组A及对照组B（P＜0.05）；治疗后观察组IL-1、IL-6、TNF-α、IFN-γ表达水平均降低，与对照组A及对照组B比较，差异有统计学意义（P＜0.05）；治疗后观察组NO、MDA表达水平降低，SOD表达水平升高，与对照组A及对照组B比较，差异有统计学意义（P＜0.05）。 结论TENS联合通络祛痹膏治疗KOA疗效明显，止痛效果显著，能有效减轻患者关节炎症及氧化应激反应。
Abstract:
ObjectiveTo explore curative effects of transcutaneous electrical nerve stimulation (TENS) and collateral-dredging arthralgia-removing ointment for external application in the treatment of knee osteoarthritis and its influence on synovial immune cells and knee function. MethodsSixty KOA patients were divided into the control group A, the control group B and the observation group with 20 cases in each group according to random number table method, the control group A was treated by TENS, the control group B by external use of collateral-dredging arthralgia-removing ointment + diclofenac sodium enteric-coated tablets, and the observation group by external use of collateral-dredging arthralgia-removing ointment + TENS, all the groups were treated for six weeks. To compare the expressions of IL-1, IL-6, TNF-α, IFN-γ, NO, SOD and MDA before and after the treatment in the three groups, VAS and LKSS were applied to assess the recovery conditions of knee joint. ResultsAfter the treatment, VAS scores of the observation group were lower than these of the control group A and the control group B (P<0.05), LKSS scores higher than these of the control group A and the control group B (P<0.05); after the treatment, the levels of IL-1, IL-6, TNF-α, IFN-γ were lowered in the observation group, the difference had statistical meaning when compared with the control group A and the control group B (P<0.05); after the treatment, the expressions of NO and MDA were lowered, while the levels of SOD were increased in the observation group, the difference had statistical meaning when compared with the control group A and the control group B (P<0.05). ConclusionTENS and collateral-dredging arthralgia-removing ointment are effective in the treatment of knee osteoarthritis eivdently, and could effectively relieve joint inflammation and oxidative stress response with noticeable effects of relieving pain.

相似文献/References:

[1]王艳丽,庞颖.膝关节置换术的围手术期护理与预后分析[J].西部中医药,2013,26(06):117.
　WANG Yanli,PANG Ying.Perioperative Care and Prognosis of Knee Replacement[J].Western Journal of Traditional Chinese Medicine,2013,26(08):117.
[2]张建林.中药熏洗联合关节内注射玻璃酸钠治疗膝骨关节炎30例疗效观察[J].西部中医药,2012,25(09):80.
　ZHANG Jian-lin.Curative Observation on Fumigation with Herb and Intra-Articular Sodium Hyaluronate Injection in Treating 30 Cases of Knee Osteoarthritis[J].Western Journal of Traditional Chinese Medicine,2012,25(08):80.
[3]王亚伟,张彦军.中西医综合治疗膝骨性关节炎疗效观察[J].西部中医药,2012,25(05):80.
　WANG Ya-wei,ZHANG Yan-jun.Observation on Comprehensive Treatment of Knee Osteoarthritis with Integrated Traditional Chinese and Western Medicine[J].Western Journal of Traditional Chinese Medicine,2012,25(08):80.
[4]尤从新.樊成虎教授治疗膝关节骨性关节炎经验[J].西部中医药,2014,27(12):33.
[5]李向军,王海东△.辨位定点针刀松解术治疗膝骨性关节炎162例[J].西部中医药,2015,28(06):118.[doi:2015/6/16 0:00:00]
[6]李宁,李应福,谢兴文,等.兰州地区膝关节骨性关节炎的中医证候分布特点[J].西部中医药,2016,29(02):95.
　LI Ning,LI Yingfu,XIE Xingwen,et al.Distribution Features of TCM Syndromes of Knee Osteoarthritis in Lanzhou City[J].Western Journal of Traditional Chinese Medicine,2016,29(08):95.
[7]姚兴璋,李兴勇,李喜香,等.骨痹止痛液对兔膝骨性关节炎软骨中相关因子表达影响的研究[J].西部中医药,2016,29(04):29.
　YAO Xingzhang,LI Xingyong,LI Xixiang,et al.Study on the Influence of GuBi ZhiTong Liquid on Cartilage-related Factors Expressions of the Rabbits with Knee Osteoarthritis[J].Western Journal of Traditional Chinese Medicine,2016,29(08):29.
[8]李素明,杭柏亚△.痹痛合剂对OA大鼠关节软骨形态学变化及软骨细胞Bcl-2基因表达的影响[J].西部中医药,2016,29(05):18.
　LI Suming,HANG Baiya.The Influence of BiTong Mixture on the Expression of Cartilage Cells Bcl-2 and Articular Cartilage Morphological Changes of OA Rats[J].Western Journal of Traditional Chinese Medicine,2016,29(08):18.
[9]贾潇,尤从新,颜春鲁,等.祛寒逐风合剂对阳虚型膝骨性关节炎患者内源性透明质酸水平的影响[J].西部中医药,2016,29(05):79.
　JIA Xiao,YOU Congxin,YAN Chunlu,et al.The Influence of QuHan ZhuFeng Mixture on the Levels of Endogenous Hyaluronic Acid of the Patients with Knee Osteoarthritis of Yang Deficiency Pattern[J].Western Journal of Traditional Chinese Medicine,2016,29(08):79.
[10]陈小平,王志旺,刘彩民△,等.荣骨定痛膏对骨性关节炎大鼠IL-1β、NO及氧自由基代谢的影响[J].西部中医药,2016,29(07):23.
　CHEN Xiaoping,WANG Zhiwang,LIU Caimin,et al.The Influence of RongGu DingTong Ointments on IL-1β, NO and Oxygen Free Radical Metabolism of OA Rats[J].Western Journal of Traditional Chinese Medicine,2016,29(08):23.
[11]田雪梅,张丽君,柳树英.中医外治法辨证治疗膝骨性关节炎120例[J].西部中医药,2012,25(10):95.
　TIAN Xue-mei,ZHANG Li-jun,LIU Shu-ying.Syndrome Differentiation of TCM External Treatment for 120 Cases of Knee Osteoarthritis[J].Western Journal of Traditional Chinese Medicine,2012,25(08):95.
[12]赵道洲,郑恒恒.手法配合陇中Ⅰ号汽雾透皮疗法治疗膝骨性关节炎的临床研究*[J].西部中医药,2013,26(04):36.
　ZHAO Daozhou,ZHENG Hengheng.Clinical Study on Manipulation and Gansu Mist Transdermal Therapy No.1 in Treating Knee Osteoarthritis[J].Western Journal of Traditional Chinese Medicine,2013,26(08):36.
[13]李兴勇,徐霞,麻虎,等.中医药治疗膝关节骨性关节炎的现状[J].西部中医药,2013,26(12):144.
　LI Xingyong,XU Xia,MA Hu,et al.Progress of Treatment for Knee Osteoarthritis by TCM[J].Western Journal of Traditional Chinese Medicine,2013,26(08):144.
[14]陆金金,欧阳八四.电针与温针灸治疗瘀血阻滞型膝骨关节炎的疗效比较[J].西部中医药,2014,27(04):119.
　LU Jinjin,OUYANG Basi.Comparison of Clinical Effects between Acusector and Warm Needling Moxibustion in Treating Knee Osteoarthritis of Blood Stasis Obstruction Pattern[J].Western Journal of Traditional Chinese Medicine,2014,27(08):119.
[15]李春娥,董建文,王文波.膝关节骨性关节炎熏洗方用药规律文献研究[J].西部中医药,2015,28(03):97.
[16]王想福,石瑞芳,武纪玲,等.玻璃酸钠单独使用与联合解毒消瘀膏治疗膝骨性关节炎疗效观察[J].西部中医药,2015,28(03):118.
[17]周天恒.针灸治疗膝骨性关节炎临床观察[J].西部中医药,2015,28(04):123.
[18]李莉红,孙士杰,张选平,等.耳针与灸法并用对膝骨性关节炎患者Lysholm评分及VAS积分的影响[J].西部中医药,2016,29(04):109.
　LI Lihong,SUN Shijie,ZHANG Xuanping,et al.Influence of Ear Acupuncture and Moxibustion on Lysholm Scales and VAS of the Patients with Knee Osteoarthritis[J].Western Journal of Traditional Chinese Medicine,2016,29(08):109.
[19]刘明,指导：李兴勇.李兴勇教授治疗膝关节骨性关节炎经验小结[J].西部中医药,2017,30(04):42.
　LIU Ming,Director: LI Xingyong.Professor LI Xingyong′s Experience on the Treatment of Knee Osteoarthritis[J].Western Journal of Traditional Chinese Medicine,2017,30(08):42.
[20]郝峰.中药提速透化结合点穴按摩治疗膝骨性关节炎90例[J].西部中医药,2017,30(10):105.
　HAO Feng.Herbs Accelerating Permeabilization Combined with Acupoint Massage in Treating 90 Cases of Knee Osteoarthritis[J].Western Journal of Traditional Chinese Medicine,2017,30(08):105.

备注/Memo

备注/Memo:
陈转艮（1978—），女，副主任中药师。研究方向：中药个体膏方的治疗。E-mail：chenzhuangen@126.com。广东省中医药局科研项目（20221413）。
更新日期/Last Update: 2024-08-15